Imran S. Haque

Music-Based Magnetic Resonance Fingerprinting to Improve Patient Comfort During MRI Exams The unpleasant acoustic noise is an important drawback of almost every magnetic resonance imaging scan. Instead of reducing the acoustic noise to improve patient comfort, a method is proposed to mitig...

If you ever done an MRI you know about all the weird sounds it makes. Well, weird no more!

There's a sequence (MRF-Music) that makes the sounds you hear during an MRI to play at the beat of any song you want. This will make the exam much more tolerable and confortable
Link: tinyurl.com/bdhwnsak

I actually don't hate this visualization. There are two takeaways: (1) how far away is the red line from the dashed x=y and (2) how good is the fit of the points to the red line anyway?

Agreed that the dashed line is low contrast and so if you don't look carefully you'll miss point 1...

Graph of maternal mortality rate against year for the UK. Rate bounces until and down around 500 deaths per 100,000 births until about 1940, when it falls sharply. It’s been very low (~1–3 per 100,000) ever since.

This graph is astonishing. The people that bang on about “natural birth” and “women have been doing this forever without help” need to be forced to stare at this until their eyes water.

Admiral Popeye's.

Description of R package gaston from https://cran.r-project.org/web/packages/gaston/gaston.pdf

No... one...
Pipes like gaston
Mends stats gripes like gaston
No one analyzes genotypes like gaston

Inside U.S. health agencies, workers confront chaos and questions as operations come unglued The Trump administration’s remaking of HHS — in a matter of weeks — is sparking basic questions about how parts of the agency and those it oversees can continue to function.

Can the #HHS agencies continue to function, given the deep cuts to administrative staff in the recent layoffs? Employees of these agencies are expressing deep fears that so much of the scaffolding is gone that the edifices could crumble. www.statnews.com/2025/04/11/h...

How Measles Attacks an Unvaccinated Child With falling vaccination rates and outbreaks that have caused more than 580 U.S. cases and at least one death, health experts expect hundreds or even thousands more to be infected in the coming months...

Here is a look at how measles — one of the world’s most infectious viruses — takes over the body.

I think this opinion piece also demonstrates what arguments are likely to be the most convincing to your representative, if they are a Republican

High-frequency location data show that race affects citations and fines for speeding Prior research on racial profiling has found that in encounters with law enforcement, minorities are punished more severely than white civilians. Less is known about the causes of these encounters and...

Using data on more than 220,000 individuals on Lyft, researchers report in Science that drivers of color are significantly more likely to receive speeding tickets than white drivers, and to face steeper fines, even when traveling at identical speeds. scim.ag/3QYTjOO

Thrilled to announce that I've joined @kimia-tx.bsky.social as chief technology officer. Kimia's one-of-a-kind chemistry platform is an incredible data engine for building foundation models of chemistry and applying them to dramatically accelerate exploration of small molecule space.

Lungfish xkcd.com/3064

Lightfield 4D: Instant volumetric imaging of a beating embryonic zebrafish heart Courtesy of Stone Elworthy and Emily Noël, School of Biosciences, University of Sheffield, UK

Zeiss has released its light field microscope!

zeiss.wistia.com/medias/otnxx...

@kylegriffin1.bsky.social looks like your X account got hacked.

More detail here: bsky.app/profile/recu...

NIH funding uncertainty spurs new biotech venture fund | TechCrunch Earlier this month, the Trump administration directed the National Institutes of Health (NIH) to impose limits on specific types of funding it provides to

Today, Recursion is announcing a new pre-seed venture fund – the Altitude Lab Fund – to address the #SBIR funding gap hitting early-stage #biotech startups. The fund is backed by Recursion co-founder & CEO Chris Gibson & biotech entrepreneur David Bearss. techcrunch.com/2025/02/19/n...

NIH funding uncertainty spurs new biotech venture fund | TechCrunch Earlier this month, the Trump administration directed the National Institutes of Health (NIH) to impose limits on specific types of funding it provides to

Proud to see @recursionpharma.bsky.social and Altitude Lab step up to support new translational endeavors in this time of uncertainty for sci funding with the new Altitude Lab Pre-Seed Venture Fund, helping those otherwise waiting on SBIR. See more on @techcrunch.com:

techcrunch.com/2025/02/19/n...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Today, Dr. Jan-Karl Burkhardt, MD, MBA, Division Head of Cerebrovascular Surgery at University of Pennsylvania, shared Phase 2 data for REC-994 -- the 1st industry initiated trial in #CCM - in a late-breaking oral presentation at the International Stroke Conference. ir.recursion.com/news-release...

Sometimes the experimental control is messed up – but in a really interesting way! – and it's a great 'night science' trick to make a discovery by recognizing it when it happens.

Well, it's not done up in Millennial Gray, I'll give it that.

Classics in Medicinal Chemistry #1: Atorvastatin Lipitor

I have a new blog devoted to medicinal chemistry in which I will mainly focus on classic papers.

My first installment describes the design and discovery of the amazing atorvastatin: a triumph of simple modeling, dogged synthesis and leadership decisions medchemash.substack.com/p/classics-i...

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: When the leadership of Science magazine does not seem to care about getting the facts right in a news story...

A very troubling incident occurred some years ago and I think the concerns and lessons are important.

My apologies for the length, but it is a complicated story.

So-called binder proteins (right), designed by AI, protected cells and mice from lethal doses of 3-finger toxins better than the antibodies used in conventional antivenom (left). Timothy Jenkins

Small AI-designed proteins neutralized one of cobras' nastiest venom toxins. The findings raise the question: Could AI bring antivenoms into the 21st century? That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Advancing our vision for a virtual cell: In a presentation at #JPM2025, CEO Chris Gibson shared his vision for #TechBio, in which biol & chem datasets & highly predictive ML models, including advanced protein folding, will allow us to build a true virtual cell. ir.recursion.com/static-files...

👉 Read more: ir.recursion.com/news-release...

🔹 Using our AI platform, REC-3565 was designed as a highly selective MALT1 inhibitor that could mitigate potential risks of drug-drug interaction/hyperbilirubinaemia, enhancing its potential in combination therapies. There are ~41k R/R patients w/ CLL & B-cell lymphomas in the US & EU5 annually. 🧵

🔹 Designed & optimized using AI & active learning, REC-4539 is the first reversible LSD1 inhibitor that not only targets peripheral disease but is also designed to penetrate the brain, addressing a critical unmet need. There are ~45k patients with extensive stage SCLC in the US & EU5 annually. 🧵

📣 Big news ahead of JPM: 2 of our key investigational oncology drugs have received regulatory approval to advance to clinical trials: REC-4539 – potential best-in-class LSD1 inhibitor for SCLC & other indications & REC-3565 – a potential best-in-class MALT1 inhibitor for B-cell malignancies. 🧵

1900: flu, tuberculosis, gastroenteritis 2010: heart disease, cancer, COPD

Which reminds me, if you have any doubt that our immune systems can use all the help we are able to provide, here is a summary of causes of death in Boston in 1912. Please for the love of your fellow man support antibiotics and vaccination. Source: www.nejm.org/doi/full/10....

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...