Huge congrats to you, Brenda, Basti, everyone else involved form the Schulman Lab @mpibiochem.bsky.social, Peter Murray, and collaborators Simon and Benoît @ludwigcancer.bsky.social!👏
The notion that Trp binding to an exosite gates a phosphodegron and couples metabolite availability to CK2–FBXW11-driven UPS decisions is next-level biology. 🧫🚀👏
Absolutely spectacular, @alinathielen.bsky.social!!!🔬✨
Love seeing a decades-old mystery cracked, with such an elegant mechanistic story, from CRISPRi to Biochemistry to cryo-EM!!! 👏
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1 https://www.biorxiv.org/content/10.1101/2025.11.14.688510v1
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
Having a great time at #Ub&Friends25. Fantastic lineup of speakers. I hope I get the chance to come back to the beautiful #Vienna.
Great to see this now also in print. Congratulations @leokiss.bsky.social!!! 👏👏👏
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
It seems no starter pack exists yet for the migrated #TPD community - here is an attempt at one: go.bsky.app/FreGFDW
New week, updated starter pack. Now with 69 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.
