Temperature scanning reaction calorimetry allowed us gather a near-continuous set of rate constants (thousands !!) for our redox-neutral radical cross-coupling reactions.
Then with our new mechanistic insights, we kinetically matched hydrazides with (Het)ArX to boost rxn yields up to 7x!
www.nature.com/articles/s41...
Stereoretentive Radical Cross-Coupling
Authors: Jiawei Sun, Jiayan He, Luca Massaro, David Cagan, Jet Tsien, Yu Wang, Flynn Attard, Jillian Smith, Jason Lee, Yu Kawamata, Phil Baran
DOI: 10.26434/chemrxiv-2025-h9snj
Out First Release in @science.org today, Phil Baran's group in collaboration with BMS and Pfizer showcase a wide range of cross-couplings facilitated by sulfonyl hydrazides--no external redox required
Chemsky 🧪
www.science.org/doi/10.1126/...
guys being a postdoc is so cool. I have spent my entire life wanting to be an academic and this has really locked it in for me. self doubt inherent in any competitive field aside, this is genuinely the most fun and exciting and interesting job I’ve ever had
