Dr Mark Nixon

The next LIPID MAPS #webinar is next week... if you haven't registered for this month's #webinar, titled: 'From Circulation to Cell: Steroid Trafficking in Cardiometabolic Health and Disease' with Mark Nixon, you can register here now: bit.ly/3YpTJlf

The time is now to register! Early Bird Registration Deadline is May 1st, 2025, for the #AdiposeBiology Conference happening in Montreal, Quebec, Aug 19 & 20th, 2025.

Go to: www.adiposebiology.com to secure your spot today!

#ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social

Even more exciting to see our lab’s work in the spotlight - huge congratulations to Dr Mhairi Paul for delivering an excellent poster presentation and adding yet another award to her growing collection! 👏🥂

Looking forward to the rest of the conference!

Great to be back at #SfEBES2025!

After a few years away, it’s fantastic to return to such a dynamic and supportive endocrine event by @socendocrinology.bsky.social. The advances being made in both basic research and clinical care are a real inspiration to get back to the lab!

Grants for ESE Summer School 2025 close in one week - 6 March!

Join us in Innsbruck, Austria 22-25 June 2025.

Grow as a scientist while making friends across Europe in #endocrinology.

📅 Early Bird deadline: 20 May 2025.

Register today!
👉https://ow.ly/cWmJ50UXIRe

A big thank you to the organisers and funders, including @thebhf.bsky.social and @physoc.bsky.social for putting together such a great event. Already looking forward to next year in Glasgow!

A huge well done to Mahnoor Asif, Doanne Chin and Mhairi Paul for presenting their work— all did a brilliant job representing our lab. And an extra congratulations to Mhairi Paul for winning the Best Poster Presentation award! A well-deserved recognition of her hard work and dedication.

What a fantastic day at the Scottish Cardiovascular Forum 2025! It was great to catch up with some familiar faces and have the opportunity to connect with new colleagues, all while discussing some of the wonderful cardiovascular research taking place in Scotland.

#SCF2025 #CardiovascularResearch

🚨THIS WEEKEND please join me & the @thebhf.bsky.social in inspiring the nation to learn LIFE SAVING CPR❤️🙏

450,000 people have now engaged with the FREE online training course to learn CPR in JUST 15 MINUTES!

Lets be ready to save a life

www.bhf.org.uk/how-you-can-...

ESE Summer School 2025 is now open for registration! Innsbruck, Austria 22-25 June 2025.
Grants available.

Grow as a scientist while making friends across Europe in the field of #endocrinology.

📅 Early Bird deadline: 20 May 2025.
Register today!
ow.ly/cWmJ50UXIRe

Novel pharmacological approaches to lowering blood pressure and managing hypertension Nature Reviews Cardiology - Hypertension is the leading cause of death globally but has low rates of diagnosis and treatment. In this Review, Dhaun and colleagues discuss the reasons for poor...

Weekend reading! Our latest Review discusses novel pharmacological approaches to lowering blood pressure and managing #hypertension: rdcu.be/d82w9

Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

A very innovative approach to cancer: engineering fat cells to convert to beige fat to starve tumors, outcompeting 5 types of cancer in experimental models
www.nature.com/articles/s41... @naturebiotech.bsky.social y.social @nadavahituv.bsky.social tuv.bsky.social

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

The abstract submission deadline is only ONE WEEK away!

Contribute to the Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and ESE 2025 and share your research with the #endocrine community.

Submit your abstract by 3 February.
👉 bit.ly/3PXTqcB

We're really excited to share this research exploring the unique CV risk of men and women when it comes to obesity-induced vascular dysfunction.

Huge credit to ✨ Lisa Ivatt as this was her main PhD work, but also to the co-authors & colleagues who helped guide this from concept to publication.

💡 Take home messages:

➡️ In mesenteric PVAT (mPVAT), obesity induces unique upregulation of ECM pathways in male, but not female mice.

➡️ In contrast to insulin sensitivity, the relative protection of female mice from obesity-induced mPVAT dysregulation is not mediated by ovarian hormones

For the first time in mice, we have investigated how anatomically different perivascular adipose tissue (PVAT) respond to high-fat diet, using omics approaches to assess their transcriptional signatures. In parallel, we analysed the impact of PVAT changes on vascular function.

Our latest publication is now out in Cardiovascular Diabetology as part of a special collection on Perivascular Adipose Tissue!

🐭 💓 ♂️ ♀️ "Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones"

cardiab.biomedcentral.com/articles/10....

Health misinformation is everywhere — but we’re here to set the record straight! Our award-winning podcast reveals how hormones impact all our lives. Give it a listen 🎧 ow.ly/XaY450ULTUe

Thanks to @katarney.bsky.social, first create the media, and all our experts!

GLP-1 and the Neurobiology of Eating Control: Recent Advances Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af

Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social!

academic.oup.com/endo/article...

🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic

Some birthday celebrations in the lab over the past few days for our wonderful Postdoc Mhairi - double celebration as Mhairi has also just published her main PhD paper on Wnt signalling in HFpEF. Congratulations Mhairi!

bpspubs.onlinelibrary.wiley.com/doi/10.1002/...

A scientific diagram showing the impacts of macrophage treatment in the liver. Macrophages remove scar tissue, recruit white blood cells to the liver, and encourage regrowth of healthy tissue.

Promising new cell therapy for liver disease shows positive results! Results from the MATCH trial, run by Stuart Forbes' lab in the Centre for Regenerative Medicine, were published in @nature.com Medicine today
regeneration-repair.ed.ac.uk/promising-ne...

There are many people to thank within the Centre for Cardiovascular Science @EdinburghUniversity and our wonderful collaborators @UniversityofBritishColumbia, but in particular I must thank the participants and our funders @thebhf.bsky.social and @wellcometrust.bsky.social

In brief:

🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG

🚚Increased NE in obese adipose facilitates local GC delivery

🐭🚶‍♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes

The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure Nature Communications - Corticosteroid binding globulin modulates circulating glucocorticoids, but its metabolic implications remain unclear. Here, the authors show that CBG regulators neutrophil...

Years of collaborative work, fuelled by cortisol (and coffee!), but I'm thrilled to share our passion project on neutrophil elastase-mediated regulation of adipose glucocorticoid action has finally been published in @naturecomms.bsky.social

rdcu.be/d5Mk8

www.jacc.org/doi/10.1016/...

A very proud moment to see this labour of love published in @jaccjournals.bsky.social @jaccedge.bsky.social

Most of my Co-authors have not made it over from the other place, but I’m so grateful to them as well as the patients who had faith in the study to take part

a drawing of a brain with a rainbow and a blue one ALT: a drawing of a brain with a rainbow and a blue one

Interested in how maternal stress affects the offspring’s brain? Come and do a PhD with us in beautiful Edinburgh. More info here: www.findaphd.com/phds/project...

3rd Day of Research: Three new centre Directors 🎉

We welcomed Prof Andrew Horne as new Director of the Centre for Reproductive Health, and Prof Tilo Kunath and Prof Anna Williams as new Co-Directors for the Centre for Regenerative Medicine.

📰: edin.ac/3ZCwhSG
edin.ac/3O6z14p
#12DaysOfResearch

I'm thrilled to co-organize the inaugural #AdiposeBiology conference with Jacqueline Beaudry, Hoon-Ki Sung, and @sablesys.bsky.social!

📍Montreal, Canada
📅 August 19-20, 2025

Registration opens Jan 1, 2025. Mor info in the coming weeks.

Hope to see you there! @AdiposeBiology #AdiposeBiology2025

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...