Excited to share our latest in BBI!
Chronic stress accelerates cognitive decline in the 5xFAD model, linked to changes in the neurotrophic system. We show that corticosterone impairs microglial Aβ uptake — shedding light on how stress may drive Alzheimer’s
👉 doi.org/10.1016/j.bb...

#fluorescencefriday brings you a cleared AD mouse 🧠 stained for Abeta (green) and vasculature (magenta). Colocalization is white. #lightsheetmicroscopy
👀 for Abeta in blood vessels to test for CAA or micro bleeding. Courtesy of @shahrzadbahrampour.bsky.social Luke Smolders and Arash Salahinejad

Very interesting. Congrats!
Did you find any difference in the brain regions between males and females?

BlueSky people. What’s your level of mind visualization according to this scale? I’m only a 3 or 4 😕

Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed

Morales-Botello et al., 2012

"It's a lot harder than taking even very demanding coures. What makes it difficult is that research is immersion in the unknown. We just don't know what we're doing. We can't be sure whether we're asking the right questions or doing the right experiment until we get the answer or the result."

A word cloud, created using https://scholargoggler.com/. Prominent words are mice, mouse, human, brain, genetic, analysis, BXD, family, genetics, and systems.

Just found this fun way to (re-)introduce myself using scholargoggler.com

Loving it