Sometimes we feel like one of those giant unethical experiments psychologists got to run in the 1960s, except the only research goal is to test the maxim that 'there's no such thing as a stupid question'.
1/3 New bioRxiv preprint from the lab: βMinute-scale coupling of chromatin marks and transcriptional burstsβ. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...
It has yet to be a great day when my hometown comes up on BtB...
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!
In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.
www.biorxiv.org/content/10.1...
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID βοΈπͺͺ
Spearheaded β singlehandedly β by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Dead internet theory gets yet another point on the board.
All travelers from ESTA countries (yes the ones on visa waiver programs) will have to disclose 5 years of social media + huge amounts of personal data to enter the US now. All US academic associations should now meet outside the US if we want to meet our international colleagues.
Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1
Now online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
𧬠πβππ«π ππΜπ₯π’πππ ππ πππ’π«π πππ’π«π π₯ππ¬ π πΜπ§ππ¬
Des scientifiques de l'IGMM utilisent lβembryon de drosophile pour dΓ©montrer que la rΓ©pression de lβexpression des gΓ¨nes est un mΓ©canisme beaucoup plus complexe quβattendu.
π π lnkd.in/dPqUREuf
π· Β© Mounia Lagha et Virginia Pimmett
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
Zeiss Axio A.1 and a small sample encased in a museum exhibit.
On vacation but still managed to find a microscope. Spouse is woefully unsurprised.
A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning
Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
π @hfspo.bsky.social funded Postdoc
3-year contract
Start after Dec 2025
π© Apply: mounia.lagha@igmm.cnrs.fr
Subject: "[HFSP Post doc application]"
π CV + short research summary + cover letter
π More info: euraxess.ec.europa.eu/jobs/363437
@laghalab.bsky.social @umontpellier.bsky.social @cnrs.fr
We are hiring! "Researcher in DNA-Based Information Processing Systems" (PhD or postdoc level). Co-supervision by Prof. Ralf Reussner (KIT computer science) and myself (biological systems). Combination of experiments and computational work. Please Apply / Repost!
www.pse.kit.edu/english/karr...
Come and join the team! It's a stellar group of people and some really interesting questions to dissect with all kinds of cool tools in play.
Tom Lehrer died today. He was one of the great comedians our culture ever produced. Without Tom, there's no Weird Al, probably no that entire branch of comedy.
He went alone and beat the odds.
youtu.be/frAEmhqdLFs?...
Congratulations! Looking forward to reading the final version ASAP.
In todayβs publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Hereβs how we found it: 𧡠www.science.org/doi/10.1126/... 1/11
π Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 𧬠@igmm-montpel.bsky.social
π doi.org/10.1093/nar/...
A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled βExperimentsβ and βAI,β with the caption βHOW DO ENHANCERS REALLY WORK?β Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.
Textbooks: βEnhancers are just a bunch of TFBSsβ
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 𧡠(1/n)
Free access link: rdcu.be/erD22
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
Images from the linked preprint showing Wingless stainings in the Drosophila wing imaginal disc. Targeting vps15 with two indepependent RNAi lines (paper also shows the same with a third line) does not result in a phenotype. In contrast, targeting vps15 with two independent sgRNA constructs and Cas9 results in strong accumulation of Wingless protein in perturbed cells.
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
incredible, he's actually going down, what a perfect end to the night
how much is Poilievre cursing Trump out right now, he's got to be fucking livid
check out our latest paper investigating how TF concentration affects transcription dynamics @dev-journal.bsky.social. optogenetics+mRNA #imaging in #drosophila #embryos. joint effort with @stathopouloslab.bsky.social @caltech.edu. bravo to @pimmett.bsky.social and J.McGehee.
It's always the people you most expect
www.bbc.com/news/article...
A thread about power.
There is a lesson here, about how beating autocrats like Trump involves STANDING UP to them, not backing down. Find a way to stand up.
Canada's PM told Trump to fuck off, and now Trump is treating him better.
1/
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana TΓΌnnermann and modelling by Gregory Roth
My internal blend of optimism and paranoia hopes otherwise, but nothing disappoints me so predictably quite like late-stage capitalism.
