Abin Biswas

Adaptations in Plasmodium tubulin determine distinct microtubule architectures, mechanics and drug susceptibility Nature Communications - Tubulin conservation presents a challenge to understanding microtubules’ diverse functions in eukaryotes. Here, the authors characterize the structures of P....

In vitro reconstitution is powerful: we can rebuild Plasmodium microtubule architectures from purified components and recapitulate what cells actually do 🤩

Thanks to an incredible team that made this possible 🙌 @carolynmoores1.bsky.social in particular

rdcu.be/e7eM2

The Biophysical World Inside a Jam-Packed Cell | Quanta Magazine Innovations in imaging and genetic engineering are coming together to probe the biophysics of cytoplasm inside living animals.

Density. Crowding. Tomato. Tomato 🍅

@gabepopkin.bsky.social kin.bsky.social @quantamagazine.bsky.social Thx for covering the debate! We promise we're all friends 🥰 @liamholt.bsky.social & @gwgl.bsky.social

Nothing would have been possible without @gucklab.bsky.social @vasilyzaburdaev.bsky.social

Recent studies in living animals reveal that the cytoplasm is a thick, jam-like fluid. And yet, miraculously, hoards of molecules find their way to each other in every crowded cell. www.quantamagazine.org/the-biophysi...

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de

The world has lost a true great. 😞

A cell nucleus reconstituted in vitro in Xenopus laevis (African clawed frog) egg extract. Left image shows a fluorescence image where DNA has been stained and right image shows a density map of the same nucleus aquired using Optical Diffraction Tomography (ODT).

Researchers from #MPZPM and @mpiib-berlin.mpg.de have now compared the ratio of nuclear and cytoplasmic density in different organisms and come to a surprising conclusion: the cell nucleus in eukaryotes is less dense than the rest of the cell.

👉 mpzpm.mpg.de/news/news-de...

#Physics #Medicine

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

📃 New paper alert!
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...

📢 Voices in Infection Biology
☀️ We're back from summer break with a talk by Jan Skotheim from @stanford.edu, kindly hosted by @simonereber.bsky.social.

🗓️ Wednesday, September 10
🕓 4 pm
📍 on-site seminar (Berlin)

Event info: www.mpiib-berlin.mpg.de/events/42144...

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

🚨 Paper alert!
Check out the latest work from the Reber Lab 📌 New research by @simonereber.bsky.social and @biswashere.bsky.social, now published in @natcomms.nature.com 🥳

It's here! It's out! AND It's become better 🐸

Our fundamental work on intracellular density distributions, how it influences cellular organisation & how deviations occur during pathophysiological states like senescence is out in @natcomms.nature.com

Congratulations & thank you to the entire team!

Cell state-specific cytoplasmic density controls spindle architecture and scaling - Nature Cell Biology Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...

🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control.
bit.ly/4mhMvsU

Cell state-specific cytoplasmic density controls spindle architecture and scaling - Nature Cell Biology Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...

🚨 New paper alert: cytoplasm density controls spindle architecture and size. This shows for the first time that a physical property of the cytoplasm regulates the spindle. Congrats to @simonereber.bsky.social, @tobiaskletter.bsky.social and everyone who contributed.
👉 www.nature.com/articles/s41...

Congratulations to everyone involved!!!🎉🍾🤩

Fortunate to have contributed to this beautiful work demonstrating how cytoplasmic density tunes mitotic spindle architecture 🔬📈🐸

✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry, #Xenopus 🐸 & #microtubules ✨

Join us @mpiib-berlin.mpg.de!

Beautiful work by @mctwo.bsky.social investigating the spatio-temporal dynamics of the cytoplasm using label-free tools and 🐸 extracts!

🐸 + 🔬 + 📈 = ✨

w. @gucklab.bsky.social , @simonereber.bsky.social , @vasilyzaburdaev.bsky.social

www.biorxiv.org/content/10.1...

Congrats to Mirko Pleitner for winning the FEBS Letters Poster Award! Mirko from the lab of @simonereber.bsky.social at @humboldtuni.bsky.social presented an excellent poster at the @embo.org @embl.org Symposium "Wild frontiers of model organisms". Thanks for the fantastic insights! #EESWildModels

Congrats Mirko! Proud lab colleagues & 🐸

Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...

Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...

Some frogs like it hot, others like it cold Researchers from the Max Planck Institute for Infection Biology show, how clawed frog species inhabit different climate zones thanks to small molecular adaptations

📰 For a quick summary, read our website article: www.mpiib-berlin.mpg.de/2176621/news...

Did you ever wonder how cytoplasmic properties influence mitotic spindle architecture? Come join us for an exciting seminar next Wednesday by @simonereber.bsky.social

Two positions in our lab 🐸🐛🔬 #malaria #xenopus #microtubules #biophysics #imaging #PhDlife