Prachi Stafford

Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis

Out now 👇 www.biorxiv.org/content/10.6...

Gladys Mae West obituary: mathematician who pioneered GPS technology She made key contributions to US cold-war science despite facing huge barriers as a Black woman.

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.

Which just makes me want to share it again: www.nature.com/articles/d41...

Immunologist Indira Nath would have been 88 years old today. She studied immune responses and the nerve damage caused by leprosy, which was highly prevalent in India at the time. By the end of her career, that prevalence had been knocked from 58/10,000 to 1/10,000.

#WomenInSTEM #BioSky 🧪🧬

Mathematician Gertrude Mary Cox was born 126 years ago today. She was one of the foremost statisticians of her time, whose 1950 text Experimental Designs was for decades the standard work on how to design experiments to produce statistically significant results.

#WomenInSTEM #MathSky #Statistics 🧮🧪

Two groundbreaking women of medicine share today as their birthday - Marie Durocher (b. 1809) dressed as a man to practice medicine in Brazil for a half century, while Harriette Chick (b. 1875) worked as a microbiologist, discovering the causes of both rickets and pellagra.

#WomenInSTEM 🧪⚕️

Cell cycle duration determines oncogenic transformation capacity Danian Chen, Suying Lu, Katherine Huang, Joel D. Pearson, Marek Pacal, Phillipos Peidis, Sean McCurdy, Tao Yu, Monika Sangwan, Angela Nguyen, Philippe P. Monnier, Daniel Schramek, Liang Zhu, David Santamaria, Mariano Barbacid, Nagako Akeno, Kathryn A. Wikenheiser-Brokamp & Rod Bremner https://www.nature.com/articles/s41586-025-08935-x

A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n

Carbon monoxide and Platelets: The role of CO in clotting | CO Research Carbon monoxide (CO) is a colourless, odourless gas commonly encountered in urban environments due to pollution, in occupational settings, and sometimes at home from faulty appliances. At toxic levels...

Thrilled our proposal on 'the effects of carbon monoxide on platelets' has been funded by CO Research Trust! Excited to study this under-researched area & provide new insights.
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social

Love this honest review! Will have to check out the book… based on the reader being ‘mostly miserable’ & enjoying it.

@theotherdrx.bsky.social , @campbellsg.bsky.social, @hallam-biosci-chem.bsky.social

Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University on FindAPhD.com PhD Project - Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University, listed on FindAPhD.com

📢 we have a fully-funded #PhDOpportunity 🎓🧬
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR

Schematic representation of Rab GTPases acting as “eat me” signals for selective autophagy.

In this week's #mitophagy papers, Rab GTPases take the centre stage, with a systematic study their role in autophagy, showing that multiple "Rabs" selectively mediate the degradation of mitochondria and other cellular components.

Thanks to @biomednews.bsky.social

biomed.news/bims-tofagi/...

@campbellsg.bsky.social, might be of interest

How to read a paper involving artificial intelligence (AI) This paper guides readers through the critical appraisal of a paper that includes the use of artificial intelligence (AI) in clinical settings for healthcare delivery. A brief introduction to the diff...

Our new paper!! Led by @drpauldijkstra.bsky.social with @jessrmorley.bsky.social and awesome medical student Yosra Mekki. #digitalhealth #medsky #episky

How to Read a Paper Involving AI.

bmjmedicine.bmj.com/content/4/1/...

Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

The impact of a high fat diet and platelet activation on pre-metastatic niche formation - Nature Communications Previous work has identified a link between obesity and breast cancer metastasis. Here, using preclinical mouse models, the authors show that high-fat diet promotes platelet and endothelial cell activ...

(1/2) Very happy to study of my friend @hps2022.bsky.social @cniostopcancer.bsky.social now out also at @naturecomms.bsky.social.

Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...

Interesting thread on how glycans targeting vaccines could help against coronaviruses. The possibility of a universal vaccine again them!

a man and a woman are standing next to each other with the words " are here to view the snogestories " written below them ALT: a man and a woman are standing next to each other with the words " are here to view the snogestories " written below them

Love it! One of my favourites…

Plasticity of the mammalian integrated stress response - Nature A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 ...

www.nature.com/articles/s41...

Plasticity of the mammalian integrated stress response

Bastounis, E. E., Serrano-Alcalde, F., ..., García-Aznar, J. M., & Theriot, J. A. (2021). Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. Developmental cell, 56(4), 443–460.e11. #EpithelialMechanics
buff.ly/c4eJTxW

Developmental mitochondrial complex I activity determines lifespan | EMBO reports imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...

New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...

Re: 23andme.com & company takeover. You might want to request deletion of your data & destruction of your sample if you used this service.

Catalysing Diversity- A Chemistry Seminar Series for All- In person A series of talks to improve visibility of scientists from diverse backgrounds and identities in Chemistry and chemical sciences.

In person: www.eventbrite.co.uk/e/catalysing...

Join remotely:
www.eventbrite.co.uk/e/catalysing...

Dr Pooja Goddard is tomorrow’s speaker for our RSC inclusion & diversity talk. Join us online or in person at Sheffield Hallam University.

📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.

🎤 Speaker: Dr Pooja Goddard

📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC

New discovery from Fabiola Del Carpio-Cano on the role of RUNX1 regulates platelet-megakaryocyte F13A1 expression, impacting clot stabilization.

Read the full study: www.rpthjournal.org/article/S247...

#platelets #RUNX1

🔬 Happy #InternationalWomensDay! Proud to be one of the many women in #Biosciences & #Chemistry working to make a difference in #Science and #Education through #Research and #Teaching. 🧪📚 Love working with this inspiring bunch. #IWD2025 #WomenInSTEM @hallam-biosci-chem.bsky.social
#ChemSky #BioSky

Talk by Professor Robert Mokaya, OBE, FRS on March 5th at Sheffield Hallam University from 5-6 pm. Hybrid delivery see links below to register.

📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.

🎤 Speaker: Prof Robert Mokaya, OBE, FRS

📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC

#rnasky #microsky

Artificial intelligence can be biased against certain people. Here's how. YouTube video by PBS NewsHour

youtu.be/zPEGX8bke_o?...