Dr June M McKoy

Future Panc CA treatment…
Pancreatic cancer is immunologically cold and nonresponsive to checkpoint inhibitors @leonidasplatan1.bsky.social & team have shown immune activation correlating with tumor effects after disrupting Schlafen5 (an intracellular immune checkpoint). @drjunejd.bsky.social

Plasma Phosphorylated Tau 217 and Incident MCI and Dementia in Older Women This cohort study examines associations of baseline plasma phosphorylated tau 217 with incident mild cognitive impairment (MCI) or dementia and whether associations vary by age, race, APOE ε4 carrier ...

Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70
jamanetwork.com/journals/jam...

Aah… sleep; a must engage podcast. Replete with invaluable information @drjunejd.bsky.social

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...

Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance
@naturemedicine.bsky.social

nature.com/articles/s41...

"Immune Reset"
Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases
nature.com/articles/s41...
erictopol.substack.com/p/the-exhili...

A funny thing happened on my way home to Chicago…a bona fide Valentine’s wedding and photo shoot in our iconic Union Station!
Happy Valentine’s Day 💕everyone @drjunejd.bsky.social

What's happening during attention lapses after poor sleep?
A fluid wave. Your brain is trying to clean itself, to wash away waste products.
nature.com/articles/s41...
gift link
wsj.com/health/welln...

The draft guideline update for "Breast Cancer Follow-Up After Primary Treatment" is now available. Help us refine these standards of care. Submit your feedback to @ascocancer.bsky.social by February 23!

Read & comment here: https://bit.ly/4ccwl2h
#bcsm #BreastCancer

Congratulations to Dr Melissa Simon on being chosen to receive the 2026 Woman in Science Award from the American Medical Women’s Association (AMWA) at the 111th Annual AMWA Meeting, March 27-29 in San Francisco, CA. So proud of my close friend and research collaborator! @drjunejd.bsky.social

Opinion | Humans Possess One Thing That A.I. Does Not: Judgment

Valuing human judgement
"A.I. excels at pattern recognition, code generation and the synthesis of large volumes of text and data. But someone still has to decide whether an analysis is trustworthy, what implications it carries and whether acting on it would be wise."
www.nytimes.com/2026/01/25/o...

I'm so sad to hear that Dr Bill Foege passed away yesterday

He was a legend in global health and worked so hard to eradicate smallpox

More importantly, he was kind, compassionate and understood the true mission of public health

"The purpose of public health is to promote social justice" - Foege

Don’t miss the 2026 Medical Oncology In-Training Exam on Feb. 24 & 25! This proctored, Internet-based exam is a great way to track trainee progress across key domains. Discounts available.

Learn more & register: shorturl.at/aAOkI

I’m a member of a strong, cohesive, and collaborative team..at an innovative institution. We provide exceptional care to patients, many of whom are navigating a new cancer diagnosis. The team feels valued, supported, and reconnected w/ the reasons that we first chose medicine @drjunejd.bsky.social

Participated in a great presentation/discussion on “physician burnout” on Friday 1/9th at MCW. A stark reminder that the call to “self-care” is enduring.
Before we can care for others we MUST care for ourselves @drjunejd.bsky.social

Merry Christmas! We’re on call today and the rest of the holiday weekend. We feel privileged to provide support to our patients and their families and we are deeply touched by their kindness to us even as they face serious illness @drjunejd.bsky.social

Congratulations to the new Geriatrics diplomates of the ABIM! Welcome to the family. So proud of you! @drjunejd.bsky.social

Recently consulted on a pregnant woman under 30 with met breast cancer. A multidisciplinary team is crucial to the development of a unified plan of care that considers the mother and the baby @drjunejd.bsky.social

Please vote! Less than 24 hours remain @drjunejd.bsky.social

Resolving the mysteries of brain clearance and immune surveillance This review by Kipnis et al. explores recent advances in brain fluid dynamics, emphasizing CSF flow’s role in waste clearance, the glymphatic and meningeal lymphatic systems, and neuroimmune interacti...

How do the metabolic waste products get cleared from our brain? And how does this process intersect with the brain's immune system?
An exceptional review by
@jonykipnis.bsky.social
and colleagues
cell.com/neuron/fullt...

Circulating tumour cells are a prognostic indicator in advanced high-grade serous ovarian cancer and are associated with platelets and immune cells following dissemination - British Journal of Cancer British Journal of Cancer - Circulating tumour cells are a prognostic indicator in advanced high-grade serous ovarian cancer and are associated with platelets and immune cells following dissemination

Our recent publication in British Journal of Cancer www.nature.com/articles/s41...

Is #cancer associated #thrombosis caused predominantly by the tumour or treatment. #chemotherapy has unique effects on the activated protein C pathway which may be important in VTE occuring during chemotherapy doi.org/10.1016/j.th....

The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Congratulations Prof William Brady @williambrady.bsky.social on
being named a recipient of the 2025 Kabiller Science of Empathy Prize. As Dean Cornelli notes, this award “advances the understanding of empathy and celebrates Kellogg’s rigorous approach to the subject” @drjunejd.bsky.social

Happy Halloween MedX and all those who follow and support our work. It’s nice to decompress this evening with my wonderful clinical team @drjunejd.bsky.social

Stunning Grand Rounds on “Exceptional Longevity: What’s it really like? Centenarians, their Kids, and How They Get There.”
Delivered @medicalcollegeofwi.bsky.social by renowned GeroScientist Dr Thomas Perls an international leader in the field of human exceptional longevity @drjunejd.bsky.social

‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social

#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...

I’m having an amazing time at the National Academy of Medicine (NAM) annual mtg in Washington, D.C. today. AI is front and center as physician and nurse scientists discuss AI within the framework of healthcare in all its many facets @nationalacademies.org @drjunejd.bsky.social

This Radiation Mask…

My patient graduated from cancer this week.

This mask was his constant companion. Representing struggle and resilience.

Protection and escape.
This ritual transformation.

When words are insufficient …symbols supersede @drjunejd.bsky.social