Latest posts tagged with #3Brain on Bluesky
New organoid research shows SMA affects far more than motor neurons, revealing widespread CNS disruptions. Using CorePlateโข HD MEAs, researchers found reduced activity, glutamate hyperexcitability, and showed early ASO treatment can rescue function. Huge thanks to the team! #iPSC #HDMEA #3Brain
๐๐ผ๐ ๐ฑ๐ผ๐ฒ๐ ๐๐ต๐ฒ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐ฏ๐ฎ๐น๐ฎ๐ป๐ฐ๐ฒ ๐ฒ๐
๐ฐ๐ถ๐๐ฎ๐๐ถ๐ผ๐ป & ๐ถ๐ป๐ต๐ถ๐ฏ๐ถ๐๐ถ๐ผ๐ป?
A new study by ๐๐ฟ๐ผ๐ฐ๐ฐ๐ผ et al. (๐๐ฟ๐ฒ๐บ๐ถ๐๐ถ ๐๐ฎ๐ฏ) uses stem cell-derived DT/VT populations on CorePlateโข to map how E/I ratios shape network dynamics. Vital research for understanding neurodevelopmental disorders.
#3Brain #HDMEA #electrophysiology
How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlateโข 3D electrodes, the ๐๐ถ๐ ๐๐ฎ๐ฏ recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids
How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlateโข enabled HD-MEAs.
#Neuroscience #3Brain #Electrophysiology #HDMEA
