#AAVVector

@braincase.bsky.social

3 months ago

Cracking the AAV Expression Problem: No Signal? Weak Fluorescence? Here’s Your Step-by-Step Fix from Virus to Detection Learn how to solve AAV expression loss and weak fluorescence with step-by-step optimization of vector design, viral titer, injection dose, timing, detection, and sample processing.

🧬 AAV not expressing?
🔍 Weak fluorescence?
Here’s your step-by-step guide to fixing the most common AAV pitfalls—from titer and serotype to detection and sample processing.
www.ebraincase.com/support/lite...

#AAV #AAVVector #ViralVectors #GeneDelivery #GeneExpression #NeuroscienceResearch

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Brain Case

@braincase.bsky.social

5 months ago

Client Publication | Adv. Sci. | Sun Yat-sen University Teams of Peng Xiang, Xiaoran Zhang, and Xia Feng Reveal Analgesic Mechanism of MSCs via a Lung–Brain Axis Activating Npy2r Sensory Neurons Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron-Mediated Lung-to-Brain Axis.

✨Client Publication🎉
Sun Yat-sen Univ. team reports that MSCs relieve pain by activating Npy2r lung–brain neurons via the vagus→NTS→vlPAG pathway, dependent on ATP signaling. Inhaling a P2rx2 agonist also eases chronic pain.
🔗 www.ebraincase.com/support/cust...
#Npy2rNeurons
#ATPsignaling
#AAVvector

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EMBO Molecular Medicine

@embomolmed.org

9 months ago

High-purity #AAVvector production utilizing recombination-dependent minicircle formation & genetic coupling

By Hao Liu, Guangping Gao, Dan Wang & colleagues @rti-umasschan.bsky.social

🗞️ doi.org/10.1038/s443...

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Posts tagged #AAVVector