#ACSCentralScience

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

1 month ago

Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis Asymmetric catalysis is the most sustainable means of achieving efficient production of enantioenriched compounds, which are valuable to the pharmaceutical industry and advanced functionalized materials. The field has undergone considerable development since its inception about 60 years ago. The development of new chiral ligands or organocatalysts or the discovery of new reactions all led to spectacular progress in terms of activity and enantioselectivity. In this context, this Outlook article aims to highlight major advances that demonstrate the central role of asymmetric catalysis in sustainability, with the examples discussed representing a selection shaped by the authors’ scientific perspective and sensitivity. This includes recent innovations in catalyst recycling, the use of less precious and less toxic metals in asymmetric organometallic catalysis, as well as the control of the positioning of catalytic sites, to further improve their efficiency. The development of asymmetric electrocatalysis and photocatalysis as well as of mechanochemistry and continuous flow chemistry is also discussed. Finally, the complexity and step-economy issues are raised with the presentation of relevant examples of asymmetric multicatalytic processes and new challenging transformations that include late-stage functionalization reactions, molecular edition or reactions targeting the creation of axial, planar or helicoidal chirality.

Asymmetric Catalysis: Recent Advances toward a More Sustainable Synthesis | #ACSCentralScience #Outlook by Emmanuelle Schulz & co-authors | @pubs.acs.org

pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

1 month ago

From Prompt to Drug: Toward Pharmaceutical Superintelligence The convergence of generative artificial intelligence (AI) platforms and automated laboratory systems is ushering in a new era of drug discovery, in which a plain-language prompt can initiate a fully ...

Check out #JustPublished Outlook "From Prompt to Drug: Toward Pharmaceutical Superintelligence" by Alex Zhavoronkov, David Gennert, and Jiye Shi | #ACSCentralScience @pubs.acs.org

pubs.acs.org/doi/full/10....

Lingjun Li Research Group

@liresearch.bsky.social

2 months ago

Integrated Structural and Glycoproteomic Profiling Reveals Protein Conformational Remodeling and Biomarkers Across Alzheimer’s Disease Progression Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and protein misfolding, yet the structural dynamics of proteins and their post-translational modifications during disease pro...

Our latest study on the first integrated structural proteomics (LiP-MS+FAIMS-DIA) and N-glycoproteomics analysis of paired serum and CSF samples across AD stages is now published in #ACSCentralScience 🥳🥳
Congrats to Haiyan and all co-authors🎊🎊
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

6 months ago

Excited to share our new ☀️Collection☀️ in #ACSCentralScience, highlighting the central role of #enantioselectivity in natural product synthesis & drug discovery! ⏩ pubs.acs.org/page/acscii/...
You can read our editorial here:
⏩ pubs.acs.org/doi/10.1021/...
#Enantioselective #Catalysis @pubs.acs.org

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

6 months ago

Check out our editorial on the latest #ACSCentralScience #Collection featuring cutting-edge #Catalyzed #Enantioselective #OrganicSynthesis! @pubs.acs.org

#ChemSky #AcademicSky
⏩ pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

7 months ago

Copper-Catalyzed Asymmetric Cyclizative Sulfinamidation: Forging Indole-Based Stereogenic Sulfur(IV) Centers and Atropisomeric Chirality The structural prominence of indole-based sulfur-containing compounds in pharmacologically relevant substances stems from their versatile biofunctional capabilities. Despite their significance, the st...

Copper-Catalyzed Asymmetric Cyclizative Sulfinamidation: Forging Indole-Based Stereogenic Sulfur(IV) Centers and Atropisomeric Chirality | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Paulo C. T. Souza

@pauloctsouza.bsky.social

7 months ago

The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior Lipid membranes are central to cellular life. Complementing experiments, computational modeling has been essential in unraveling complex lipid-biomolecule interactions, crucial in both academia and industry. The Martini model, a coarse-grained force field for efficient molecular dynamics simulations, is widely used to study membrane phenomena but has faced limitations, particularly in capturing realistic lipid phase behavior. Here, we present refined Martini 3 lipid models with a mapping scheme that distinguishes lipid tails that differ by just two carbon atoms, enhancing the structural resolution and thermodynamic accuracy of model membrane systems including ternary mixtures. The expanded Martini lipid library includes thousands of models, enabling simulations of complex and biologically relevant systems. These advancements establish Martini as a robust platform for lipid-based simulations across diverse fields.

Our collaborative work "The #Martini3 #Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior" is now published in #ACSCentralScience! 🎉

📄 Read: pubs.acs.org/doi/10.1021/...

💾 GitHub: github.com/Martini-Forc...

#MolecularDynamics #Biophysics #Simulations #Lipids

Carla Obradors

@carlaobradors.bsky.social

8 months ago

Predictable C–H Functionalization of Complex <italic toggle="yes">beta</italic>-Fused Azines: A Mechanistically Bound Site-Specific Oxidation Direct manipulation of C–H bonds enclosed in complex scaffolds persists today as an elusive disconnection when aiming for high and predictable site-selectivity. Its development toward the late-stage d...

Check out this new direct #CHfunctionalization method for fused azines at #ACScentralscience : broad, metal-free and proceeding with exclusive and predictable #regiocontrol! Executed in #parallelmode for its immediate application to #drugdiscovery! 💊

pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

9 months ago

Light-Powered Late-Stage Alkylation of N-Heteroaromatics in Flow Continuous-flow photochemistry allows late-stage functionalization of N-heteroaromatics with gaseous alkane.

Light-Powered Late-Stage Alkylation of N-Heteroaromatics in Flow | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

9 months ago

Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide, with an underdetermined absolute stereochemistry (1 or ent-1), is a newly identified 6,12-guaianolide isolated from the genus Anvillea garcinii. Motivated by the potential biological activity of the natural product, we pursue its stereoselective synthesis. Starting from (R)-limonene, an asymmetric total synthesis of 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1) is accomplished in 20 steps with an overall yield of 4%, utilizing key transformations such as stereoselective reductive epoxide opening and additions of methyl lithiopropiolate and allyl cuprate. Most significantly, preliminary biological testing uncovers new anticancer activity of 1 against rare and aggressive childhood atypical teratoid rhabdoid tumor (ATRT) and other cancer cell lines. We anticipate that our synthetic strategy will enable the development of chemical probes and derivatives derived from 1 for mechanism of action studies and anticancer drug discovery.

Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

9 months ago

Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor Multicomponent reactions are powerful tools for expanding the chemical space in drug discovery, yet achieving selectivity remains a formidable challenge. Here, we introduce a multicatalytic strategy t...

Multicatalysis-Enabled Multicomponent Reactions Generate a PTP1B Inhibitor | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Mechanism of O₂ Activation and Cysteine Oxidation by the Unusual Mononuclear Cu(I) Active Site of the Formylglycine-Generating Enzyme The formylglycine-generating enzyme (FGE) catalyzes the selective oxidation of a peptidyl-cysteine to form formylglycine, a critical cotranslational modification for type I sulfatase activation and a useful bioconjugation handle. Previous studies have shown that the substrate peptidyl-cysteine binds to the linear bis-thiolate Cu(I) site of FGE to form a trigonal planar tris-thiolate Cu(I) structure that activates O2 for the oxidation of the Cβ–H of the cysteine substrate via an unknown mechanism. Here, we employed a combination of stopped-flow kinetic, spectroscopic (UV–vis absorption, XAS, and EPR), and computational (DFT/TD-DFT calculations) methods to observe and characterize the key intermediates in this reaction for FGE from Streptomyces coelicolor. Our results define the reaction coordinate of FGE, which involves H-atom abstraction from the Cβ–H bond of the cysteine substrate by a reactive Cu(II)–O2•– species to form the now experimentally observed Cu(I)–OOH intermediate bound to a peptidyl-thioaldehyde, which proceeds to oxidize one of the protein-derived cysteine residues to a sulfenate that is end-on O-coordinated to Cu(I). These results provide fundamental insights into how the unusual mononuclear Cu(I) site of FGE activates O2 for cysteine oxidation and stores oxidizing equivalents during catalysis by employing a Cu(I)–sulfenate intermediate with an end-on O-coordination that is unprecedented in biology.

Mechanism of O2 Activation and Cysteine Oxidation by the Unusual Mononuclear Cu(I) Active Site of the Formylglycine-Generating Enzyme | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Rh(I)-Catalyzed Modular Synthesis of Axially Chiral Alkylidene Azacycloalkanes The structural prevalence of chiral N-bridged cyclic scaffolds in pharmacologically relevant substances originates from their multifaceted biofunctional capacities, particularly in privileged natural product architectures. Despite advances in central chirality, the precise and expeditious construction of axially chiral N-bridged cyclic scaffolds with impeccably full enantiocontrol and highly structural diversity remains largely underexploited due to the lack of efficient synthetic methods. Here, we disclose an unprecedented Rh(I)/diene-catalyzed carbene coupling reaction of arylboronic acid with β-hydroxy α-diazocarbonyl compounds through a remotely controlled desymmetrization strategy, furnishing a diverse array of three-dimensional nonatropisomeric axially chiral alkylidene N-bridged [3.2.1] and [3.3.1] ring systems. This straightforward methodology operates without redox requirements, demonstrating extensive applicability across diverse substrates (>50 examples) while maintaining exceptional control of chemo- and enantioselectivity (up to 97% yield, mostly 95–99% ee). The synthetic utility of these compounds was further validated via sequential elaboration processes, allowing for modular assembly of novel N-bridged bicyclic systems with configurationally defined axial chirality.

#DiamondOpenAccess Rh(I)-Catalyzed Modular Synthesis of Axially Chiral Alkylidene Azacycloalkanes | #ACSCentralScience @pubs.acs.org pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N-Heterocycles via Copper-Catalyzed Dearomative Cyclization Significant advancements have been made in the catalytic asymmetric dearomatization of indoles for constructing valuable chiral polycyclic N-heterocycles. However, the asymmetric dearomative cyclopropanation of indoles continues to pose a formidable challenge. Furthermore, the diverse transformations of indoline-fused cyclopropanes via strain release remain largely unexplored, potentially unveiling new chemistry. Here, we disclose a Cu-catalyzed asymmetric dearomative cyclopropanation of indole-diynes and subsequent [3 + 2] cycloaddition with oxygen, facilitating the divergent and atom-economical synthesis of enantioenriched cyclopropane- and 1,2-dioxolane-fused indolines with moderate to excellent yields and generally outstanding diastereo- and enantioselectivities with broad substrate scope. Importantly, this protocol not only represents the first asymmetric dearomative cyclopropanation of indoles utilizing alkynes as carbene precursors but also constitutes the first catalytic asymmetric construction of chiral 1,2-dioxolanes with high stereoselectivity. Interestingly, Brønsted acid-promoted ring-opening and rearrangement of cyclopropane-fused indolines display distinctive chemoselectivity to afford enantioenriched cyclohepta[b]indoles in good to excellent efficiency and enantiocontrol. In addition, both potential reaction pathways and the origins of chiral control within this Cu-catalyzed asymmetric tandem sequence are robustly supported by control experiments and theoretical calculations.

Divergent and Enantioselective Synthesis of Three Types of Chiral Polycyclic N-Heterocycles via Copper-Catalyzed Dearomative Cyclization | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects Large library docking of tangible molecules has revealed potent ligands across many targets. While make-on-demand libraries now exceed 75 billion enumerated molecules, their synthetic routes are dominated by a few reaction types, reducing diversity and inevitably leaving many interesting bioactive-like chemotypes unexplored. Here, we investigate the large-scale enumeration and targeted docking of isoquinuclidines. These “natural-product-like” molecules are rare in current libraries and are functionally congested, making them interesting as receptor probes. Using a modular, four-component reaction scheme, we built and docked a virtual library of over 14.6 million isoquinuclidines against both the μ- and κ-opioid receptors (MOR and KOR, respectively). Synthesis and experimental testing of 18 prioritized compounds found nine ligands with low μM affinities. Structure-based optimization revealed low- and sub-nM antagonists and inverse agonists targeting both receptors. Cryo-electron microscopy structures illuminate the origins of activity on each target. In mouse behavioral studies, a potent joint MOR-antagonist and KOR-inverse-agonist reversed morphine-induced analgesia, phenocopying the MOR-selective antioverdose agent naloxone. Encouragingly, the isoquinuclidine induced less severe opioid-withdrawal symptoms versus naloxone and did not induce conditioned-place aversion, reflecting reduced dysphoria, consistent with its KOR-inverse agonism. The strengths and weaknesses of bespoke library docking and of docking for opioid receptor polypharmacology will be considered.

#DiamondOpenAccess Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects | #ACSCentralScience @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Facile Access to Hindered Ethers via Photoinduced O–H Bond Insertions The synthesis of the hindered and polyfluorinated dialkyl ethers poses challenges owing to the bulkiness of tertiary alcohols and the low nucleophilicity of polyfluorinated alcohols. Additionally, associated competitive side reactions always provide poor reactivities. Although certain strategies, such as electrocatalytic decarboxylation and hydroalkoxylation, have been explored, a straightforward method for obtaining ethers with structural diversity remains elusive. In this study, we have exploited the photoinduced approach that involves the in situ formation of singlet carbenes followed by O–H insertions to access the hindered and polyfluorinated ethers with congested or polyfluorinated alcohols. Moreover, other nucleophiles such as phenols, H2O, thiols, silanols, tributyltin hydride, etc., are also tolerable to obtain valuable products. The gram-scale synthesis of marketed drugs and the modification of complex molecules demonstrate the practicality of this approach. The detailed mechanistic studies have elucidated the key intermediates and reaction mechanism, which were distinct from traditional metal-carbenoid O–H insertions.

Facile Access to Hindered Ethers via Photoinduced O–H Bond Insertions | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation A multidisciplinary platform is presented to address aryl hydrocarbon receptor (AhR) modulation. A rewired Yonemitsu multicomponent reaction with indole 2-carboxaldehydes and nucleophilic species was designed to access a family of 6-substituted indolocarbazoles. The conformational behavior of these compounds was examined to rationalize their axial chirality. In silico docking and molecular simulations highlighted key features implicated in their binding to AhR. Furthermore, the synthesis of linkable derivatives allowed the direct development of conjugated entities. Reporter gene and target gene expression analyses identified these novel structures as potent noncytotoxic activating AhR ligands, that can be extended to bifunctional molecules. The anti-inflammatory properties of these AhR agonists were assessed in interleukin-13 treated keratinocytes. Altogether, the synergistic research in synthetic and computational chemistry integrated with biological studies opens novel avenues toward understanding the biological roles of AhR and the development of targeted therapeutics.

#DiamondOpenAccess A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation | #ACSCentralScience @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow The late-stage functionalization of complex molecules is a pivotal strategy in drug discovery, enabling the rapid optimization of lead compounds. However, the use of gaseous alkanes as alkylating agen...

Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow | #ACSCentralScience #DiamondOpenAccess @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome Mutanofactins are a family of natural products produced by Streptococcus mutans from the human oral microbiome. We report a unified approach to all mutanofactins by developing a total synthesis amenab...

#DiamondOpenAccess Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome | #ACSCentralScience @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

10 months ago

Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport Organic electrosynthesis opens new avenues of reactivity and promises more sustainable practices in the preparation of fine chemicals and pharmaceuticals. The full value of this approach will be reali...

#DiamondOpenAccess Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport | #ACSCentralScience @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Noel Research Group

@noelgroupuva.bsky.social

10 months ago

Our latest study presents a photocatalytic platform that enables the Minisci alkylation of heteroarenes using C1-C4 hydrocarbons under continuous-flow conditions.

No prefunctionalized reagents—just change the gas to vary the alkyl moiety!

Now at #ACSCentralScience: pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

11 months ago

Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome Mutanofactins are a family of natural products produced by Streptococcus mutans from the human oral microbiome. We report a unified approach to all mutanofactins by developing a total synthesis amenable to diversification. The key to success for the most complex members, mutanofactins 607 and 697, was an acyl ketene based strategy. Access to the family enabled comprehensive biological profiling, where we demonstrate that all mutanofactins are biofilm promoting in Streptococcus mutans. Experiments were extended to other inhabitants of the oral microbiome for the first time: Streptococcus gordonii and Streptococcus oralis, two early colonizers, were similarly affected with mutanofactins being biofilm promoting. Conversely, Veillonella dispar and Fusobacterium nucleatum showed little to no reaction to mutanofactins. Biophysical investigations based on quartz crystal microbalance with dissipation monitoring and atomic force microscopy reveal a previously unknown mucin–mutanofactin 697 interaction. Incubation of a mucin layer with mutanofactin 697 induces a morphology change within the mucin layer, which promotes bacterial adhesion and biofilm formation. This unique property of mutanofactin 697 might be key to early stages of biofilm formation in the human oral microbiome. Combined, an interdisciplinary approach consisting of total synthesis, microbiology and biophysical characterization provides insight into the roles of mutanofactins in the oral microbiome.

Check out a new interesting #ACSCentralScience article "Synthesis, #Microbiology & #Biophysical Characterization of #Mutanofactins from the Human Oral Microbiome" by Erik Reimhult, Christina Schäffer, Erick M. Carreira & co-workers. #ChemSky #AcademicSky @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

11 months ago

Data-Driven Workflow for the Development and Discovery of <italic toggle&#x3D;"yes">N</italic>-Oxyl Hydrogen Atom Transfer Catalysts N-oxyl species are promising hydrogen atom transfer (HAT) catalysts to advance C–H bond activation reactions. However, because of the complex structure–activity relationship within the N-oxyl structure, catalyst optimization is a key challenge, particularly for simultaneous improvement across multiple parameters. This paper describes a data-driven approach to optimize N-oxyl hydrogen atom transfer catalysts. A focused library of 50 N-hydroxy compounds was synthesized and characterized by three parameters─oxidation peak potential, HAT reactivity, and stability─to generate a database. Statistical modeling of these activities described by their intrinsic physical organic parameters was used to build predictive models for catalyst discovery and to understand their structure–activity relationships. Virtual screening of 102 synthesizable candidates allowed for rapid identification of several ideal catalyst candidates. These statistical models clearly suggest that N-oxyl substructures bearing an adjacent heteroatom are more optimal HAT catalysts compared to the historical focus, phthalimide-N-oxyl, by striking the best balance among all three target experimental properties.

Check out a new excellent #ACSCentralScience article "Data-Driven Workflow for the #Development & #Discovery of N-Oxyl #HydrogenAtomTransfer Catalysts" by Stephen Maldonado, Matthew S. Sigman, Corey R. J. Stephenson and co-workers.
#ChemSky #AcademicSky @pubs.acs.org
pubs.acs.org/doi/10.1021/...

Svetlana Tsogoeva

@svetlanatsogoeva.bsky.social

1 year ago

Happy to introduce our new Special Collection featuring cutting-edge research recently published in #ACSCentralScience!
⏩ pubs.acs.org/page/acscii/...
Don’t miss our Editorial!
⏩ pubs.acs.org/doi/10.1021/...

@acspublications.bsky.social #ChemSky #AcademicSky #Medsky #HigherEd

Sofia Garakyaraghi

@sgarakyaraghi.bsky.social

1 year ago

Our November Issue of #ACSCentralScience went live last week! pubs.acs.org/toc/acscii/1...

Cover story by John Hartwig & team. Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization pubs.acs.org/doi/10.1021/...
@acspublications.bsky.social

Sofia Garakyaraghi

@sgarakyaraghi.bsky.social

1 year ago

Recycling of Post-Consumer Waste Polystyrene Using Commercial Plastic Additives Photothermal conversion can promote plastic depolymerization (chemical recycling to a monomer) through light-to-heat conversion. The highly localized temperature gradient near the photothermal agent s...

Recycling of Post-Consumer Waste Polystyrene Using Commercial Plastic Additives

by Erin Stache and co-workers in ACS Central Science

#chemsky #ACSCentralScience
@acspublications.bsky.social

pubs.acs.org/doi/10.1021/...

Sofia Garakyaraghi

@sgarakyaraghi.bsky.social

1 year ago

Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization Methyl groups are ubiquitous in natural products and biologically active compounds, but methods for their selective transformation in such structures are limited. For example, terpenoids contain many ...

Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization

by John Hartwig and co-workers in ACS Central Science.

pubs.acs.org/doi/10.1021/...

@acspublications.bsky.social
#ChemSky #ACSCentralScience