Latest from @pujol-lab.bsky.social shows how a transient #aECM factor organizes furrow collagens in the #Celegans cuticle
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#AECM
Latest posts tagged with #AECM on Bluesky
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Posts tagged #AECM
👉 2nd aECM club on Feb 10th 10-11:30 am NYC 4-5.30 pm Paris
#aECM trafficking and processing
program sundaramlab.com/blog/aecm-cl...
👉 join our Slack forms.gle/Y6UjbnXPH1pD...
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Lipocalins and Scavenger Receptors affect the luminal matrix that prevents narrow tubes from collapsing - now in press in Development! #aECM #Celegans
journals.biologists.com/dev/article/...
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#aECM club
sundaramlab.com/blog/aecm-cl...
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it's all #aECM to me
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#aECM at #CellBio2025 On Sunday, the Sundaram lab will have 2 posters on #Celegans aECM - boards 223 and 225
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#aECM at #CellBio2025 Deepak Krishnamurthygave a fascinating talk about how choanoflagellates use glycans to help build 3D basket structures or « lorica » around themselves
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#aECM folks take note!
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#aECM CLUB
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#aECM Cub starts next week Nov 18 with talks on patterning the Drosophila lens, mouse tectorial membrane, and C.elegans cuticle furrows. You can still sign up for access using the link below.
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The 2025-2026 #aECM club schedule is now posted on our website, where you can also find the link to sign up for access. I’m looking forward to lots of great talks and discussions! sundaramlab.com/blog/aecm-cl...
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Back to the office after a great time at the GFÖ conference! We shared talks & posters on bee health, ground-nesting, grassland #Restoration, bird #Conservation, combinations of landscape-scale conservation measures, and the establishment of perennial flower fields as #AECM.
@gfoesoc.bsky.social
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Plots showing how many collagens, ZP domain proteins, or other ECM families are expressed in a pulsatile manner in each cell type.
Using these new tools, we could ask what kinds of genes oscillate in glia, or skin, or pharynx. For glia and skin it turns out it's mostly #aECM - lots of collagens, ZP domain proteins, and other cuticle proteins. Pharynx has a different kind of cuticle and its oscillatory genes reflect that.
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PCA plot of C. elegans ILso glia, with each cell colored by the established timing of the genes it expresses. Cells of similar color are adjacent to each other in PCA space, showing that the main source of transcriptional variation in these cells is explained by their timing within each larval stage.
We had shown that glia make the cuticle #aECM around neuronal cilia. So, we wondered if loops were a transcriptional cycle tied to cuticle synthesis.
We used expression data from @labgrosshans.bsky.social to color-code each cell based on when in the larval stage its genes are expressed. Bingo!
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In this study, we uncover the critical role of #sulfation —a key post-translational modification of proteins and proteoglycan side chains—in organizing the apical extracellular matrix (aECM) during tubulogenesis. While the #aECM is essential for tissue development, it is still poorly understood.
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🚨pre-print alert🚨
Excited to share the latest work on how cell specific secretion of chitin controls the shape of the fly corneal lens, an #aECM structure.
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If you liked this article, you might be interested in the new #aECMClub starting Fall2025 -a virtual seminar series to highlight work on #aECM across different organisms. 🪱🪰🐟🐁👳♀️🌱🦠
Sign up here: 👉https://forms.gle/Y6UjbnXPH1pDHAE97
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Starting Fall2025 there will be a new virtual seminar series to highlight work on #aECM across different organisms. 🪱🪰🐟🐁👳♀️🌱🦠
If you are interested, sign up here:
👉https://forms.gle/Y6UjbnXPH1pDHAE97
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There is so much cool #aECM work going on but most of the researchers don’t know or talk to each other; this is an attempt to change that! Link below
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... a new virtual seminar series on apical extracellular matrix #aECM on different #organisms 🪱🪰🐁🌱🦠will start in Fall 2025, with short talks and discussions
If you are interested
👉https://forms.gle/Y6UjbnXPH1pDHAE97
@meera-sundaram.bsky.social @gotworms.bsky.social @heiman.bsky.social
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Catching up on more #aECM at #worm25 by watching the online videos: Physiology1 Talk23 from Jonathan Hodgkin provided evidence that, via social interactions, worms can transfer surface glycans (« BIM ») between each other to affect pathogen sensitivity. So cool!
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#aECM at #worm25 (Neurobiology session) on my list to watch online, Fumie Hiramatsu talking about how social cues in cuticle let predatory Pristionchus know who to bite and not bite to avoid killing their own family members
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#aECM at #worm25 Two posters from my lab today - come talk!
272C Assembly and Clearance of the Pre-cuticle matrix
373C Decoding vulval cell identity: Insights from single-nucleus RNA Sequencing
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#aECM at #worm25 : At the aECM workshop, Pooranachithra Murugesan described the ~100 protein fusions made by the Ward and Chisholm labs, identifying collagens present in different cuticle layers, tissues, and substructures - a great resource for the worm community!
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Prioty Sarwar: cool results showing spectrin defining middle ridge of adult alae #aECM #worm25 cell biology session
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#aECM at #worm25: Talk this morning (Cell Bio session) by Prioty Sarwar from my lab
A role for the spectrin cytoskeleton in cuticle alae patterning
9:06 AM - 9:18 AM
Program Number: 66
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