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Have I burnt your eyes through my aura? Aww poor boy! ๐Ÿ˜‚๐Ÿ‘ ๐Ÿ–•๐Ÿป

@findompromo.bsky.social
@promodog.bsky.social

#bosslady #arpi #goddessarpi #ladyrules #bossbabe

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I know how to train ๐Ÿถs, wanna try out?

@findompromo.bsky.social
@promodog.bsky.social

#bdsm #femdom #indiangoddess #realsession #dominatrix #mistress
#goddessarpi #bosslady #arpi #kolkata

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The lioness doesn't chase, she rules! ๐Ÿ‘ข๐Ÿ‘‘

@findompromo.bsky.social
@promodog.bsky.social

#femdom #bdsm #Indiamistress
#humiliation #finsub #slave
#arpi #goddessarpi #bosslady #ladyrules

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Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits

Sadly only 17% of pts in #Talapro2 study were treated with subsequent #Parp

That is one among many questions about these parp and #arpi studies raised in this commentary @asco #GU25 #ProstateCancer

ascopubs.org/doi/10.1200/...

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Worth revisiting the #BRCAway trial from #GU24 in the context of #GU25 and #Talapro2

With regard to evaluation of sequencing #Parp and #ARPI the numbers of pts are very small (8 with cross over) and the CIs are very wide.
#ProstateCancer

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A related question on #Talapro2 that remains unanswered is sequencing of #ARPI & #parp aside from a very small phase 2 trial with far too few pts

Sequencing #Parp would defer toxicity for mos-yrs

& worth noting that low% of mCRPC pts getting 2nd line tx predates #parp era
#GU25

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