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#ASCVD

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ACC/AHA & 9 other leading medical associations released an updated clinical guideline for managing #dyslipidemia. About 1 in 4 US adults has high LDL-C, raising risk of heart attack & stroke.

Get the details in #JACC: https://bit.ly/4cLB0J0

#ClinicalGuidelines #cvLipids #ASCVD #CardioSky

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Recent advances in research and care of familial hypercholesterolaemia Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular di...

Despite advances, #familial #hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early #cardiovascular disease www.thelancet.com/journals/lan...
#HeFH #HoFH #ASCVD

#MedSky #EndoSKY #CardioSky

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New complimentary #CME!
Get a quick, practical update on LDL-C management in high-risk #ASCVD, including clinical data on new and emerging PCSK9 inhibitors (injectable & oral).

Earn 0.5 CME in 30 minutes.
clinical.med-iq.com/activity/ldl...

#CardioTwitter #MedEd #PCSK9

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1/24 In this #CME #MedX, Dr. Blaha explores the evolving landscape of LDL-C management in high-risk patients with #ASCVD, with a focus on the role of PCSK9 inhibitors and a look at emerging novel PCSK9 inhibitor formulations.
Produced w/ @accintouch.bsky.social
Get credit: link.med-iq.com/Xc4w8B

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Recent advances in research and care of familial hypercholesterolaemia Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular di...

With major advances in knowledge about the disease, #familial #hypercholesterolaemia has become an exemplar for the practice of precision and personalised medicine thelancet.com/journals/lan...
#HoFH #HeFH #ASCVD

#MedSky #EndoSky #CardioSky

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Bar graphs show smallest worthwhile difference distributions for atherosclerotic cardiovascular disease risk in the US & Japan. Baseline risks are 2%, 10%, & 20%. X-axis: SWD in absolute risk reduction from baseline. Y-axis: percentage of US/Japanese participants.

Bar graphs show smallest worthwhile difference distributions for atherosclerotic cardiovascular disease risk in the US & Japan. Baseline risks are 2%, 10%, & 20%. X-axis: SWD in absolute risk reduction from baseline. Y-axis: percentage of US/Japanese participants.

Most statin-eligible adults in the US and Japan desire greater absolute risk reduction than current statin efficacy provides before initiating therapy for #ASCVD prevention.

ja.ma/46MbaRa

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Editorial titled, "Statins for Primary Prevention—The Gap Between Guidelines and Patient Preferences" by Ilana B. Richman et al. Text discusses when to use statins for preventing atherosclerotic cardiovascular disease (ASCVD).

Editorial titled, "Statins for Primary Prevention—The Gap Between Guidelines and Patient Preferences" by Ilana B. Richman et al. Text discusses when to use statins for preventing atherosclerotic cardiovascular disease (ASCVD).

💬 Editorial: Statin guidelines and patient preferences for #ASCVD prevention often misalign, supporting the need for clearer risk communication and shared decision-making in clinical practice.

ja.ma/4rKRFAo

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Bar graphs show smallest worthwhile difference distributions for atherosclerotic cardiovascular disease risk in the US & Japan. Baseline risks are 2%, 10%, & 20%. X-axis: SWD in absolute risk reduction from baseline. Y-axis: percentage of US/Japanese participants.

Bar graphs show smallest worthwhile difference distributions for atherosclerotic cardiovascular disease risk in the US & Japan. Baseline risks are 2%, 10%, & 20%. X-axis: SWD in absolute risk reduction from baseline. Y-axis: percentage of US/Japanese participants.

Most statin-eligible adults in the US and Japan desire greater absolute risk reduction than current statin efficacy provides before initiating therapy for #ASCVD prevention.

ja.ma/4kDy02Y

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Enlicitide substantially lowers LDL-C in people at risk for atherosclerotic CVD events The oral PCSK9 inhibitor enlicitide significantly reduces LDL-cholesterol levels in people with a history of, or risk for, atherosclerotic cardiovascular disease events.

#MedNews - The oral PCSK9 inhibitor #enlicitide significantly reduces LDL-C levels in people with a history of, or risk for, #ASCVD events.

Full story 👉 buff.ly/jS4MBME

#CardioSky

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New findings highlight clinician-level variation in lipid management for secondary ASCVD prevention, revealing opportunities to standardize care and improve outcomes.
🔗 https://ow.ly/7swS50Y8VHm

#LipidManagement #ASCVD #PreventiveCardiology #PracticeImprovement #CardioSky #MedSky

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What predicts diffuse coronary artery calcium in adults ≥75?
New data from the ARIC study identify clinical predictors of diffuse CAC, offering insight into advanced atherosclerosis phenotypes in older adults.

🔗 https://ow.ly/EV4H50Y6mzu

#CardioEpi #CAC #ASCVD

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Inclisiran for children: is it worth it? Familial hypercholesterolaemia is one of the most common inherited metabolic disorders, with heterozygous familial hypercholesterolaemia (HeFH) affecting more than 30 million individuals worldwide, a ...

Lluís Masana & Daiana Ibarretxe comment on:
Inclisiran for children: is it worth it? thelancet.com/journals/lan...
#heterozygous #familial #hypercholesterolaemia #HeFH #ASCVD

#MedSky #EndoSky #CardioSky

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P. gingivalis in #Atherosclerotic plaques exacerbates plaque instability by disrupting the FOXO3-HDAC2 axis, driving #OxidativeStress-mediated macrophage #Necroptosis, thus establishing a causative link between periodontal health and #ASCVD.

#OpenAccess: doi.org/10.1038/s413...

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The application of implementation science to expanding knowledge of #familial #hypercholesterolaemia has enabled the development and design of potentially more effective models of care thelancet.com/journals/lan...
#HoFH #HeFH #ASCVD

#MedSky #EndoSky #CardioSky

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SURPASS-CVOT Published: Large Trial Confirms CVD Efficacy of Tirzepatide The drug was as good as a proven GLP-1, giving doctors another potent option for patients with type 2 diabetes and atherosclerotic cardiovascular disease.

💊The newly published SURPASS-CVOT trial shows tirzepatide (Mounjaro) is as effective as dulaglutide in reducing major cardiovascular events in patients with type 2 diabetes and #ASCVD, expanding treatment options.

Read more in this TCTMD article➡️ https://ow.ly/izET50XTbeT

#CardioSky

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Although heterozygous #familial #hypercholesterolaemia represents one of the most common monogenic conditions in the general population, homozygous familial hypercholesterolaemia is much rarer, occurring in between one in 160 000 & one in 450 000 individuals www.thelancet.com/journals/lan...
#ASCVD

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Heart Attack Screening Tools Miss Nearly Half Of At-Risk People, Study Finds - IndiaWest News Heart Attack Screening Tools Miss Nearly Half Of At-Risk People, Study Finds.

Heart Attack Screening Tools Miss Nearly Half Of At-Risk People, Study Finds

Full Story: indiawest.com/heart-attack...

#HeartAttackRisk #HeartHealthStudy #HeartAttackScreening #CardiovascularRisk #SilentHeartDisease #ASCVD #PREVENTScore #MountSinaiStudy #HealthAlert

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📣 #Colchicine for the prevention and management of Atherosclerotic #Cardiovascular Disease ⬇️

📌 In this review, van Zelm and colleagues review the evidence for the use of colchicine in #ASCVD

🆓 on TH 👉 www.thieme-connect.de/products/ejo...

#CardioEd #CAD #Cardiology #Cardiosky

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Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study Declines in heart failure mortality in both people with and without diabetes were less marked than were declines in CHD and cerebrovascular disease mortality in most jurisdictions. Heart failure morta...

Current efforts to manage #diabetes appear to have narrowed the gap between people with and without diabetes in terms of atherosclerotic CVD mortality, but not in terms of heart failure mortality www.thelancet.com/journals/lan...
#ASCVD #heartfailure

#MedSky #EndoSky #CardioSky

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Despite advances, #familial #hypercholesterolaemia remains an underdiagnosed and untreated condition, with an urgent need for the design and implementation of effective models of care www.thelancet.com/journals/lan...
#ASCVD #HeFH #HoFH

#MedSky #EndoSky #CardioSky

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Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study Declines in heart failure mortality in both people with and without diabetes were less marked than were declines in CHD and cerebrovascular disease mortality in most jurisdictions. Heart failure morta...

In four of seven jurisdictions with #heartfailure data available, declines in heart failure mortality were less marked than declines in mortality due to #atherosclerotic #cardiovascular disease in people with & without #diabetes www.thelancet.com/journals/lan... #ASCVD

#MedSky #EndoSky #CardioSky

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New study: Analysis of the Family Heart Database® (2022–23) reveals gaps in cholesterol management among U.S. adults with a family history of ASCVD, highlighting key opportunities for improvement in care.
🔗 https://ow.ly/EI8G50XxfPj

#Cholesterol #ASCVD #PreventiveCardiology

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From the November issue: Study by Zhao et al suggests we are under treating #ASCVD in patients with #dermatomyositis https://ow.ly/l9Q050WCTmY #medderm #dermsky

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Join us November 27 for our new series on ASCVD lipid management — LDL targets, new therapies, Lp(a), and imaging strategies. Don't miss this quick, high-value session for cardiovascular professionals.
🔗Register now: https://bit.ly/4oTK2a1
#cardiosky #ASCVD

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The application of implementation science to expanding knowledge of #familial #hypercholesterolaemia has enabled the development and design of potentially more effective models of care www.thelancet.com/journals/lan...
#ASCVD #cholesterol

#MedSky #EndoSky #CardioSky

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We're excited to share breakthrough preclinical data across our cardiometabolic pipeline presented at #AHA25, highlighting our comprehensive strategy to address the key drivers of #ASCVD.

Thanks to Fierce Biotech‘s Darren Incorvaia for the feature:
www.fiercebiotech.com/research/scr...

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FDA Expands Approvals For Repatha® and Leqvio® For LDL-Cholesterol Management - Family Heart Foundation For many individuals and families, managing high LDL-C, often called "bad cholesterol," is a constant challenge. This is especially true for those living with inherited conditions like Familial…

🧬Molecule of the Moment | #Leqvio® (#Inclisiran) received #FDA approval for new indication enabling #first-line use, highlighting its role in #cholesterol management.
✨MedChemExpress offers Inclisiran sodium for research use only. familyheart.org/fda-expands-...
#FDAApproval #ASCVD

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Recent advances in research and care of familial hypercholesterolaemia Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular di...

Although #heterozygous #familial #hypercholesterolaemia was traditionally thought to affect approximately one in 500 individuals in the general population, multiple contemporary epidemiological studies have revealed that this condition is much more common www.thelancet.com/journals/lan...
#ASCVD

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Cardiovascular mortality trends among people with and without diabetes Cardiovascular disease (CVD), a composite of coronary heart disease (CHD), cerebrovascular disease, and heart failure, remains the leading cause of morbidity and mortality worldwide. Although mortalit...

Linked Comment by Ranjit Mohan Anjana:
#Cardiovascular mortality trends among people with and without #diabetes thelancet.com/journals/lan...
#T2D #ASCVD #heartfailure

#MedSky #EndoSky #CardioSky

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