#Aging_Cell

Hao Yin

@haoyin.bsky.social

2 months ago

80-mer DNA aptamer as a selective marker for #Senescence
Targeting EDA-Fibronectin Kd 500~1000 pM

Label senescent cells in naturally aged🐭🫁
Aptamer binding ⬇️in 21-mo INK-ATTAC🐭 with p16 cells eliminated

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...

Thiard News@F4F

@newsen.bsky.social

9 months ago

Circulate Health Reveals Study Results on Therapeutic Plasma Exchange and Biological Age Reduction Circulate Health's latest study reveals that therapeutic plasma exchange can significantly reduce biological age, showing promise for longevity.

Circulate Health Reveals Study Results on Therapeutic Plasma Exchange and Biological Age Reduction #United_States #Novato,_California #Circulate_Health #Therapeutic_Plasma #Aging_Cell

Hao Yin

@haoyin.bsky.social

10 months ago

#CalorieRestriction #VascularAging #Progeroid🐭

CR (30%⏬, 7- to 22-wk) in ERCC1Δ/−🐭 rescues #AorticAging
⏬elastin breaks
⏬proteoglycan
⏬MMPSense680
⏬ssDNA-cGAS-STING1
⏬inflamm VCAM1+ or LGALS3+ #SmoothMuscleCell

+Aortic bulk RNAseq

#Aging_Cell 2025
onlinelibrary.wiley.com/doi/10.1111/...

Hao Yin

@haoyin.bsky.social

1 year ago

#HutchinsonGilfordProgeriaSyndrome

HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)

#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...

Hao Yin

@haoyin.bsky.social

1 year ago

#Oocyte #Aging #Heterochromatin

Mouse 9- vs 2-mo
Human <35 vs >35 y/o

Aging▶️
⏬Heterochromatin
⏫DNA damage
⏫Retrotransposon transcription dsRNA Dicer

Overexpression of Sirt1 or EZH2 in aged oocytes to rescue

#Aging_Cell 2022
onlinelibrary.wiley.com/doi/10.1111/...

Hao Yin

@haoyin.bsky.social

1 year ago

In vivo & In vitro Causal evidence of #EndothelialCell #Senescence as a driver of #Aging-related Compromise of #BloodBrainBarrier

Old INK-ATTC🐭(p16-hi cell elimination)

Senescent+ Healthy EC co-culture

#Aging_Cell 2024
onlinelibrary.wiley.com/doi/full/10....