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Persister cells reactivated multiple signaling survival pathways, including #MAPK, #PI3K/ #AKT and #mTOR. #CDK1 activity increased markedly, and inhibiting CDK1 significantly reduced persister cell survival and regrowth.

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How exactly does #PLK1 function in prophase?
Peter Lenart @plenart.bsky.social and coworkers find its inhibition to delay #CDK1 activation and mitotic entry, inducing a prolonged and phenotypically variable prophase-like state
www.embopress.org/doi/full/10....

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