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#CDK8

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Posts tagged #CDK8

Chemical Probes Portal
Chemical Probes Portal
@chemicalprobes.org
8 months ago

🧪 As a complement to CCT251545 and CCT251921, the study also highlights MSC2530818 as a valuable orthogonal CDK8/19 probe, further strengthening confidence in on-target effects and enabling robust mechanistic studies.
#ChemicalProbes #CDK8 #TargetValidation

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Chemical Probes Portal
Chemical Probes Portal
@chemicalprobes.org
8 months ago
Preview
Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer The Mediator complex is a regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is controlled by a protein kinase module, which inclu...

New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target.
Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19.
🔗 pubs.acs.org/doi/10.1021/...
#ChemicalProbes #CDK8 #OnTarget

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