Latest posts tagged with #CPEB4 on Bluesky
Imagen de conexiones neuronales
Drs. Garcia-Cabau and Bartomeu recently published in the prestigious journal @nature.com the role of the #CPEB4 protein in neuronal development, which appears to be defective in some cases of #ASD.
@xsalvatella1.bsky.social @bist.eu @cerca.cat
🔬 Major advance in #AutismResearch: Dr. Carla Garcia-Cabau (IRB Barcelona) explains the key role of #CPEB4 condensates in #autism.
📰 Published in Nature
📌 DOI: doi.org/10.1038/s41586-024-08289-w
#IRBScience @xsalvatella1.bsky.social @natureportfolio.bsky.social
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#PCBCommunity | A team of scientists, led by Raúl Méndez & @xsalvatella1.bsky.social, at @irbbarcelona.bsky.social has identified a molecular mechanism that explains why certain alternations of the neuronal protein #CPEB4 are associated with idiopathic #autism.
📝 @natureportfolio.bsky.social
New findings from IRB show CPEB4 condensates disrupt synaptic processes by 40% in autism, offering new therapeutic targets #autism #CPEB4
go.nature.com/4fZhKq9
Rau en la pèrdua d’un microexó, que repercuteix en la pėrdua de 8 aminoàcids (aa) de la proteïna #CPEB4, 8 aa que són crítics per a la plasticitat d’aquesta proteïna.
Avenç clau en autisme: descobert el paper crucial dels condensats de la proteïna #CPEB4 La manca del microexó en CPEB4 afavoreix l'evolució dels condensats en agregats. www.irbbarcelona.org/ca/news/cien...
🗣️Dr. @xsalvatella1.bsky.social: "In this study, we’ve discovered that this neuronal microexon is crucial for maintaining the condensates' stability & dynamics formed by #CPEB4 in neurons. Without it, condensates are less dynamic and can form solid aggregates that don’t work correctly."
The work published today in Nature reveals that this small fragment is key for neuronal activity because it preserves the flexibility of #CPEB4 to assemble into condensates and disassemble them.
Back in 2018, the researchers observed that, in individuals with autism, the #CPEB4 protein lacked a specific neuronal microexon —a tiny segment of genetic material crucial for protein function in the neurons.
The study is based on previous work published in 2018 that identified #CPEB4 as a key protein in the regulation of neuronal proteins related to #autism.
➡️ tinyurl.com/4y9ryuxy
📌 Nature @natureportfolio.bsky.social DOI: 10.1038/s41586-018-0423-5
A team of scientists led by Dr. Raúl Méndez & Dr. @xsalvatella1.bsky.social at #IRBBarcelona has identified a molecular mechanism that explains why certain alternations of the neuronal protein #CPEB4 are associated with idiopathic autism.
🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed.
💊The study opens new avenues for the development of targeted treatments for autism.
📰 Nature @natureportfolio.bsky.social
✍️ Carla Garcia-Cabau, Anna Bartomeu et al.
➡️ bit.ly/3BfEGlR
📌 DOI: 10.1038/s41586-024-08289-w
