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Unlocking LAG3: Ubiquitin’s unexpected role The inhibitory receptor LAG3 is the target of the FDA-approved mAb relatlimab, but its mechanism of signaling is not well understood. In this issue of Cell, Jiang et al. demonstrate that ubiquitinatio...

🔓 New #CellPreview by Prof. Kai W. Wucherpfennig @harvard.edu highlights our work on LAG3!

Key take:
• Cbl-mediated, non-degradative poly-ubiquitination at K498 unlocks LAG3 signaling
• Marks TILs that respond to PD-1/LAG3 combo

#LAG3 #Immunotherapy #PD1 #TCell
www.cell.com/cell/fulltex...

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