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Posts tagged #ColabFold

🎙️ Thanks to everyone that helped on this project: Nicola Wood, Thomas Macartney, MRC PPU Reagents and Services, Dundee Uni DTS, @bartongrp.bsky.social, @jalview.bsky.social team, James Abbot and also @martinsteinegger.bsky.social and his team for the excellent #ColabFold implementation!

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🎙️ Thanks to everyone that helped on this project: Nicola Wood, Thomas Macartney, MRC PPU Reagents and Services, Dundee Uni DTS, @bartongrp.bsky.social, @jalview.bsky.social team, James Abbot and also @martinsteinegger.bsky.social and his team for the excellent #ColabFold implementation!

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In this illustration, Bubb et al. highlight a lightning bolt striking rare hematopoietic and leukemic stem cells. The lightning bolt represents the extracellularly linked concatemeric trivalent cytokine, or ELECTRIC, approach, in which the apex of healthy and malignant hematopoiesis is eliminated with a targeted non-genotoxic cell therapy to enable hematopoietic stem cell transplantation. The lightning bolt is composed of various in silico models of the ELECTRIC protein binding KIT, MPL, or FLT3 and the ELECTRIC bispecific T cell engager (BITE). Image credit: Gerardo Sotillo.

In this illustration, Bubb et al. highlight a lightning bolt striking rare hematopoietic and leukemic stem cells. The lightning bolt represents the extracellularly linked concatemeric trivalent cytokine, or ELECTRIC, approach, in which the apex of healthy and malignant hematopoiesis is eliminated with a targeted non-genotoxic cell therapy to enable hematopoietic stem cell transplantation. The lightning bolt is composed of various in silico models of the ELECTRIC protein binding KIT, MPL, or FLT3 and the ELECTRIC bispecific T cell engager (BITE). Image credit: Gerardo Sotillo.

Our work is on the cover of @moltherapy.bsky.social Oncology! Big shout-out to #ColabFold for generating so many in-silico models of the ELECTRIC Chimeric Antigen Receptor (CAR) and ELECTRIC Bispecific T Cell Engager (BITE). 🧪

Link to paper: www.cell.com/molecular-th...

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#SaprotHub: Making #protein #modeling accessible to all biologists:

-create & train own #DeepLearning models without the need for advanced #MachineLearning & coding expertise

doi.org/10.1101/2024...
#DIYbio #bioinformatics #CompChem #AI #ML #KI #LLM #AF2 #ESMfold #ColabFold #sciece #research

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Exploring AI-Based Protein Sequence Generation with EvoDiff from Microsoft Research EvoDiff is a new, state-of-the-art protein sequence generation system from Microsoft Research. How well does it work?

Protein Sequence Generation with EvoDiff: colbyford.medium.com/exploring-ai...

#proteins #diffusion #ai #computationalbiology #bioinformatics #rfdiffusion #alphafold #colabfold

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