Cryptococcus luteus
#Cryptococcusluteus #Cryptococcus #Filobasidiellalutea #Filobasidiella #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends
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#Cryptococcus
Latest posts tagged with #Cryptococcus on Bluesky
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Posts tagged #Cryptococcus
An in vivo image of the mouse brain showing two Cryptococcal colonies with microglia association. Capillary vessels are shown in magenta. The mouse was intravenously infected with GFP-expressing Cryptococcus neoformans for 48 h.
How do #brain #macrophages detect pathogens without direct contact? This study shows that #microglia sense capsular components from capillary-bound #Cryptococcus via endothelial nucleotide signaling, triggering uptake but not clearance @plosbiology.org 🧪 plos.io/4rYS9Dt
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An in vivo image of the mouse brain showing two Cryptococcal colonies with microglia association. Capillary vessels are shown in magenta. The mouse was intravenously infected with GFP-expressing Cryptococcus neoformans for 48 h.
How do #brain #macrophages detect pathogens without direct contact? This study shows that #microglia sense capsular components from capillary-bound #Cryptococcus via endothelial nucleotide signaling, triggering uptake but not clearance @plosbiology.org 🧪 plos.io/4rYS9Dt
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An in vivo image of the mouse brain showing two Cryptococcal colonies with microglia association. Capillary vessels are shown in magenta. The mouse was intravenously infected with GFP-expressing Cryptococcus neoformans for 48 h.
How do #brain #macrophages detect pathogens without direct contact? This study shows that #microglia sense capsular components from capillary-bound #Cryptococcus via endothelial nucleotide signaling, triggering uptake but not clearance @plosbiology.org 🧪 plos.io/4rYS9Dt
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great case from latest NEJM: new #HIV diagnosis with #PJP pneumonia & isolated #cryptococcus pneumonia without meningitis. Lessons: everyone should get hiv test/we do this in our ED. other clues recent zoster. pic: crushed ping pong balls: #pneumocystis DOI: 10.1056/NEJMcpc25135 Pt doing well on ART
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Overlooked molecule points to new treatments for #drug-resistant #fungal #infections ...
| #drugresistance | #fungi | #Cryptococcus | #pathogen | By @mcmasteruniversity.bsky.social via @sciencex.bsky.social
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Cryptococcus luteus
#Cryptococcusluteus #Cryptococcus #Filobasidiellalutea #Filobasidiella #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends
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Cryptococcus luteus
#Cryptococcusluteus #Cryptococcus #Filobasidiellalutea #Filobasidiella #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends
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Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
www.sciencedirect.com/science/arti... #mycology #Candida #Cryptococcus #MicroSky #MedSky
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Intracellular C. neoformans infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages
Callison, E. N. et al.
Paper
Details
#Cryptococcus #Glycolysis #MacrophageImmunity
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Learn key urease-positive organisms and their role in infection and diagnosis. #UreasePositive #Microbiology #Proteus #Klebsiella #HelicobacterPylori #StaphylococcusSaprophyticus #Ureaplasma #Nocardia #Cryptococcus #USMLE #MedicalEducation #ClinicalMicrobiology #BacterialMetabolism
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Hot off the press: our Target Product Profile to support the development of new medicines to treat #cryptococcal disease:
www.sciencedirect.com/science/arti...
#cryptococcus, #drugdiscovery, #meningitis
@ddu-dundee.bsky.social, @gsk.bsky.social, @dndi.org and many others 🧪
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Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor
#DrugDiscovery #mycology #Cryptococcus
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Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor
#DrugDiscovery #mycology #Cryptococcus
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Top: Micrographs showing hyphal filaments extending from colony peripheries in a sexual cross between CBS8507 and CBS10435 after 2 weeks of incubation on CMA and V8 pH 5 media, in the dark, at room temperature. Insets depict two types of basidia: globose (a–c) and lageniform (b–d). Black arrows indicate clusters of cells emerging near basidia (either at the surface or embedded), scored as potential meiotic progeny (basidiospores). Bottom: Schematic representation of key chromosomal rearrangements and evolutionary events underlying transitions from tetrapolar to bipolar and pseudobipolar mating configurations. The phylogenetic tree highlights inferred changes in MAT locus structure, with color-coded branches representing both extant and reconstructed MAT configurations. Dashed lines indicate unresolved phylogenetic relationships among clades A, B, and C. Insets summarize distinct evolutionary stages, including: the ancestral organization with unlinked and compact P/R and HD loci (1); small-scale expansion of the P/R locus in Kwoniella (2); two independent large-scale expansions of the P/R locus in Cryptococcus (5); relocation of P/R and HD loci onto the same chromosome in Kwoniella resulting in either pseudobipolar (3) or fused (4) MAT configurations; and independent HD-P/R fusion events with HD gene loss in Cryptococcus pathogens and Cryptococcus sp. 3 (6). These transitions illustrate the diverse pathways by which chromosomal rearrangements (CRs) have shaped MAT locus architecture in these fungal lineages.
Evolution of fungal mating systems: Study of #Cryptococcus & Kwoniella by @marcoacoelho.bsky.social @marciadavidpalma.bsky.social &co shows that MAT locus fusions & recombination suppression drive diversity of #SexualReproduction in #fungi @plosbiology.org 🧪 plos.io/479579M
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Top: Micrographs showing hyphal filaments extending from colony peripheries in a sexual cross between CBS8507 and CBS10435 after 2 weeks of incubation on CMA and V8 pH 5 media, in the dark, at room temperature. Insets depict two types of basidia: globose (a–c) and lageniform (b–d). Black arrows indicate clusters of cells emerging near basidia (either at the surface or embedded), scored as potential meiotic progeny (basidiospores). Bottom: Schematic representation of key chromosomal rearrangements and evolutionary events underlying transitions from tetrapolar to bipolar and pseudobipolar mating configurations. The phylogenetic tree highlights inferred changes in MAT locus structure, with color-coded branches representing both extant and reconstructed MAT configurations. Dashed lines indicate unresolved phylogenetic relationships among clades A, B, and C. Insets summarize distinct evolutionary stages, including: the ancestral organization with unlinked and compact P/R and HD loci (1); small-scale expansion of the P/R locus in Kwoniella (2); two independent large-scale expansions of the P/R locus in Cryptococcus (5); relocation of P/R and HD loci onto the same chromosome in Kwoniella resulting in either pseudobipolar (3) or fused (4) MAT configurations; and independent HD-P/R fusion events with HD gene loss in Cryptococcus pathogens and Cryptococcus sp. 3 (6). These transitions illustrate the diverse pathways by which chromosomal rearrangements (CRs) have shaped MAT locus architecture in these fungal lineages.
Evolution of fungal mating systems: Study of #Cryptococcus & Kwoniella by @marcoacoelho.bsky.social @marciadavidpalma.bsky.social &co shows that MAT locus fusions & recombination suppression drive diversity of #SexualReproduction in #fungi @plosbiology.org 🧪 plos.io/479579M
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Top: Micrographs showing hyphal filaments extending from colony peripheries in a sexual cross between CBS8507 and CBS10435 after 2 weeks of incubation on CMA and V8 pH 5 media, in the dark, at room temperature. Insets depict two types of basidia: globose (a–c) and lageniform (b–d). Black arrows indicate clusters of cells emerging near basidia (either at the surface or embedded), scored as potential meiotic progeny (basidiospores). Bottom: Schematic representation of key chromosomal rearrangements and evolutionary events underlying transitions from tetrapolar to bipolar and pseudobipolar mating configurations. The phylogenetic tree highlights inferred changes in MAT locus structure, with color-coded branches representing both extant and reconstructed MAT configurations. Dashed lines indicate unresolved phylogenetic relationships among clades A, B, and C. Insets summarize distinct evolutionary stages, including: the ancestral organization with unlinked and compact P/R and HD loci (1); small-scale expansion of the P/R locus in Kwoniella (2); two independent large-scale expansions of the P/R locus in Cryptococcus (5); relocation of P/R and HD loci onto the same chromosome in Kwoniella resulting in either pseudobipolar (3) or fused (4) MAT configurations; and independent HD-P/R fusion events with HD gene loss in Cryptococcus pathogens and Cryptococcus sp. 3 (6). These transitions illustrate the diverse pathways by which chromosomal rearrangements (CRs) have shaped MAT locus architecture in these fungal lineages.
Evolution of fungal mating systems: Study of #Cryptococcus & Kwoniella by @marcoacoelho.bsky.social @marciadavidpalma.bsky.social &co shows that MAT locus fusions & recombination suppression drive diversity of #SexualReproduction in #fungi @plosbiology.org 🧪 plos.io/479579M
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Great opportunity to join our multi-partner collaboration to develop much needed new #antifungal drugs!
#jobs, #drugdiscovery, #Cryptococcus, #Candida
@mrccmm.bsky.social @ddu-dundee.bsky.social @labwyllie.bsky.social @glaxosmithkline.bsky.social
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A study reports that pladienolide B, a splicing inhibitor, reduces #Cryptococcus neoformans growth. Combined treatment with FK506 results in enhanced antifungal activity. Transcriptomic analysis reveals disrupted RNA processing and intron retention.
journals.asm.org/doi/10.1128/... #fungi #fungal
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Delighted to announce a £17.9 million award from @wellcometrust.bsky.social for the development of new antifungal treatments to a consortium of @ddu-dundee.bsky.social, @labwyllie.bsky.social, @mrccmm.bsky.social and GSK.
#Cryptococcus #Candida #drugdiscovery #antifungal 🧪
tinyurl.com/wywtkpsx
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#Deubiquitinase Ubp5 is essential for #pulmonary immune evasion and #hematogenous dissemination of #Cryptococcus neoformans
doi.org/10.1080/2150...
@tandfresearch.bsky.social
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🧫 An #IOCBPrague @czechacademy.bsky.social team led by Prof. Jan Konvalinka has developed a compound that destroys the yeast #Cryptococcus neoformans – a #fungus which is life-threatening for people with weakened immune systems – in laboratory settings. 🧵
#fungi #iocb #czechscience
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Tým vedený prof. Janem Konvalinkou připravil látku, která v laboratorních podmínkách ničí kvasinkovou houbu #Cryptococcus neoformans, smrtelně nebezpečnou pro lidi s oslabeným imunitním systémem. 🧵
#chemistry #Cryptococcus #chemie #uochb #iocb #iocbprague #antifungals #popularizace
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Over 300 potential targets uncovered for new #antifungal #drugs ...
| #infections | #fungi | #pathogens | #Cryptococcus | #HIV | Via @sciencex.bsky.social
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An Optimized In-House Protocol for Cryptococcus neoformans DNA Extraction from Whole Blood: “Comparison of Lysis Buffer and Ox-Bile Methods”
#fungifriends
#Cryptococcus
Join our whatsapp group for weekly mycological updates:
chat.whatsapp.com/D1qZFCYcW6aE...
www.mdpi.com/2309-608X/11...
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MMI PhD Candidate Gracen Gerbig who's training in the lab of @johnshopkinsmmi.bsky.social dept chair &
@johnshopkinssph.bsky.social &
@jhu-bdps.bsky.social @acasadevall1.bsky.social defends her PhD thesis today!
THURS, JUNE 5
1:00 p.m.
#Cryptococcus neoformans
#fungi
Good Luck, Gracen!
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📰 PRESS RELEASE ALERT! 🧪 New quantitative real-time PCR assays for dimorphic fungi, now available. 👇READ NOW 🔎 PRESS RELEASE:
www.eurofins-viracor.com/news-and-eve...
#Blastomyces #Histoplasma #Coccidioides #Cryptococcus #DimorphicFungi #dimorphicfungi
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Schematic of TN-seq in C. neoformans. Top left: Transposon insertions (orange arrow) into nonessential genes results in viable cells. In contrast, insertions into essential genes will result in dead and nonrecoverable cells. Top right: TN-seq works by generating a library of cells where each cell has a single independent transposon insertion in a random location. As in A, those insertions into essential regions cause the cells to die and are nonrecoverable. As a result, the total library (bottom) is depleted in insertions in essential regions. Bottom: The Ac/Ds transposon was split into an Ac transposase and a Ds transposon containing a neomycin resistance marker. This Ds transposon was integrated into an intron of URA5 and the Ac transposase was integrated into the safe haven locus. The resulting stain is ura− and neomycin resistant. Upon initiating transposition via growth on galactose, the strain becomes URA+ and mutant at another locus (depicted here as YFG1).
#Fungal infections are hard to treat due to #DrugResistance. @blakebillmyre.bsky.social &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @plosbiology.org 🧪 plos.io/4dz3iVm
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