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maybe your dog is suffering due to this too 😂

#dog #pet #cute #disease

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Experimental drug restores memory loss caused by Alzheimer's disease, defying decades of research Scientists have reversed severe memory loss caused by Alzheimer’s disease by restoring the brain’s energy supply in two mouse models. Late-stage mice showed brain tissue repairing itself once fuel balance returned, challenging the idea that Alzheimer’s only moves forward. Memory reversal in mice In two mouse strains designed to develop Alzheimer-like changes, the animals returned to normal performance even after symptoms had grown severe. By comparing mouse and human brains, Andrew A. Pieper, M.D., Ph.D., at University Hospitals (UH) traced the damage to an energy crisis. Across early and late disease stages, Pieper’s lab saw the same weak point: brains could not keep fuel chemistry stable. Instead of aiming only to slow decline, the experiments pointed toward repairs that begin when the brain’s energy balance recovers. NAD+ and brain fuel Behind that recovery sat NAD+, a helper molecule that keeps cells turning nutrients into usable energy. Every time a neuron fires and repairs itself, NAD+ helps run the chemical reactions that build proteins and fix DNA. Aging slowly drains NAD+ across the body, and the new work found an even steeper drop in Alzheimer’s brains. With cases projected to reach 153 million by 2050, a therapy aimed at recovery would...

Experimental drug restores memory loss caused by Alzheimer's disease, defying decades of research
->Earth.com | More on "Alzheimer's memory restoration energy research" at BigEarthData.ai | #Disease #Health

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重病社会|ポイズン雷花 列島を蝕む奇病「ホロージジィリゼーション合併症」の脅威。国民総“貧弱化”は誰のせいか?  現代社会に奇妙な病が蔓延している。その名は「ホロージジィリゼーション合併症」。感染すると、人々は思考力を失い、挑戦を恐れ、ささいな刺激にも耐えられない「古代ココナツ頭体型貧弱ジジィ」へと成り果てるという。本紙はこの奇病の正体と、その背後にうごめく病巣の構造を追った。 病原体は「古代ジジィ型思考」という名の有害...

重病社会
これは、社会パンデミックで有る。
汝、社会ジジィは手強いで有る。

note.com/poison_raika...

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#strange #disease #modern #society #infected #people #lose #ability #challenge #become #unable #endure #slightest #only #called #coconut #head #physically #djidjiy #paper #true #nature #structure #toxic #substance #root #extremely

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A Gravely Ill Society|ポイズン雷花 The Threat of "Hollow Djidjiylization Syndrome," a Strange Disease Eroding the Archipelago. Who is to Blame for the Nation's Total "Enfeeblement"?  A strange disease is rampant in modern society. Its ...

A Gravely Ill Society
This is a social pandemic.
You,social djidjiy are tough.

note.com/poison_raika...

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#strange #disease #modern #society #infected #people #lose #ability #challenge #become #unable #endure #slightest #only #called #coconut #head #physically #djidjiy #paper #true #nature

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Тяжкохворе суспільство|ポイズン雷花 Загроза дивної хвороби «ускладнення холлов джіджийлізатіон», що роз'їдає архіпелаг. Хто винен у загальному «ослабленні» нації?  У сучасному суспільстві поширюється дивна хвороба. Її назва — «ускладнен...

Тяжкохворе суспільство
Це соціальна пандемія.
Ти, соціальний джіджий, жорсткий.

note.com/poison_raika...

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#strange #disease #modern #society #infected #people #lose #ability #challenge #become #unable #endure #slightest #only #called #coconut #head #physically #djidjiy #paper #true #nature

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Scientists discover a new cause of autoimmune diseases Scientists have discovered a surprising link between leukemia and autoimmune diseases. A new study shows that certain genetic changes connected to leukemia can also create abnormal immune cells that mistakenly attack the body. This discovery helps explain why some people with leukemia also develop autoimmune conditions such as rheumatoid arthritis or aplastic anemia. The research was carried out by scientists at the Garvan Institute of Medical Research in Australia. Their findings provide new insight into how the immune system can go wrong and lead to both cancer and autoimmune disease. The study was led by Dr. Etienne Masle‑Farquhar and the results were published in the scientific journal Immunity. To understand this discovery, it helps to know how the immune system normally works. The immune system is the body’s natural defense system. Its job is to protect us from harmful threats such as viruses, bacteria, and abnormal cells. One important group of immune cells is known as T cells. These cells act like soldiers that patrol the body looking for danger. Among these T cells are special defenders called “killer T cells.” Their job is to destroy infected or damaged cells before they cause harm. When the immune system works properly,...

Scientists discover a new cause of autoimmune diseases
->Knowridge Science Report | More on "Leukemia genes triggering autoimmune diseases" at BigEarthData.ai | #Disease #Science #Health

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Film 2431 - Jurassic World: Rebirth Intro : I'm in my movie era once again and lately I've been trying to catch up with all the films that I missed during last year or saved "...

#JurassicWorldRebirth is nom for 1 #Oscars:
• Visual Effects

#HollywoodCiak 2430 #JurassicWorld: #Rebirth #ScarlettJohansson #MahershalaAli #JonathanBailey #RupertFriend #ManuelGarciaRulfo #EdSkrein #scifi #dinosaur #blood #disease #DNA #JurassicPark
hollywoodciak.blogspot.com/2026/01/film...

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Dementia-related plaques also form in heart disease, opening up study and potential therapy Heart failure and Alzheimer's disease are both devastating conditions that can put equal strain on patients and families. They might also be related: the same toxic proteins that cause dementia in the brain also damage the heart, causing a certain kind of heart failure that is more prevalent in women, new research shows. Finding the root of that connection, and a potential therapy for it, is the groundbreaking work of Dr. Federica del Monte at the Medical University of South Carolina. A generous gift of $5 million from anonymous donors is helping her and her team at MUSC explore this. Through a multidisciplinary clinic, they are enrolling patients in a clinical trial to look for blood biomarkers and and combining this with imaging to examine how the diseases progress while also looking at a potential targeted therapy. The work is at the forefront of an increasing focus on the connection between the heart and its diseases and the brain and dementias as doctors search for new ways to prevent and treat a growing epidemic of Alzheimer’s disease in an aging population. “What is really exciting is that we're now talking about those things together, that when we're looking at one...

Dementia-related plaques also form in heart disease, opening up study and potential therapy
->Post and Courier | More on "Dementia proteins linked to heart failure" at BigEarthData.ai | #Disease #Health

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2026 cancer report projects 100 more Iowans to die from the disease than in 2025 An estimated 21,700 new cancers will be diagnosed among Iowans, and a projected 6,400 Iowans will die from cancer in 2026, 100 more than in 2025, according to the Iowa Cancer Registry’s 2026 report published March 13. There are a projected 165 residents who will die from cancer and 6,795 survivors of the disease in Johnson County, according to the 2026 report. This year, the Iowa Cancer Registry partnered with the Agricultural Health Study an ongoing research study that explores how agricultural lifestyle factors affect the health of farmers in Iowa and North Carolina, to analyze cancer in Iowa’s farming population. Mary Charlton, professor of epidemiology in the College of Public Health and co-author of the Iowa Cancer Registry report, said partnering with the study stemmed from public concern over pesticide use. 31,433 male farmers signed up for the study when it began in the mid-1990s, along with 22,145 women, either spouses of the farmers or farmers themselves. Farmers were eligible for the study if they obtained or renewed a pesticide license. The study is still ongoing. The study found that farmers had 13 percent fewer cancer cases than expected based on Iowa’s general population cancer rate. Spouses had 10...

2026 cancer report projects 100 more Iowans to die from the disease than in 2025
->The Daily Iowan | More on "Iowa cancer deaths farming research" at BigEarthData.ai | #Disease #Health

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#Science #Nature #Pets #Dog #Vaccine #Health #Medicine #MRNA #chatGTP #AlphaFold #DNA #RNA #Immunology #DesignerDrug #TargettedMedicine #Australia #SmallPharma ( #Cancer #Cure? #Treatment ) #Vet #AI #Innovation #Pioneer #genomics #tumour #mutation #disease #Rosie

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Tickborne Diseases in Workers - Centers for Disease Control and Prevention | CDC (.gov) Ticks can be infected with bacteria, viruses, or parasites. Bites from infected ticks can pass tickborne pathogens to humans. CDC has information related to ticks and tickborne disease, including: Diseases transmitted by ticks Symptoms of tickborne diseases What to do if a tick bites you The geographic distribution of ticks Worksites with woods, bushes, high grass, or leaf litter are likely to have ticks. Ticks may be active all year in some regions with warmer weather. In the United States, they are most active in the spring, summer, and fall. Prevention Recommendations for employers Provide training for workers that includes information about: How tickborne diseases spread. Risks of exposure and infection. How workers can protect themselves from ticks. Reporting workplace illnesses and injuries. Tell workers to wear light-colored long-sleeved shirts, pants, socks, and hat when possible. If uniforms are provided, have long-sleeved shirts and pants as options. Provide workers with Environmental Protection Agency (EPA)-registered insect repellents containing one of the following: DEET Picaridin IR3535 Oil of Lemon Eucalyptus (OLE) Para-menthane-diol (PMD) 2-undecanone Provide workers with repellents (such as Permethrin) to provide greater protection. Permethrin kills ticks on contact. It can be used on clothing but not skin. When possible, have...

Tickborne Diseases in Workers - Centers for Disease Control and Prevention | CDC (.gov)
->Centers for Disease Control and Prevention | More on "Tick disease prevention workplace safety" at BigEarthData.ai | #Disease #Health #CDC

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Intraocular foreign bodies in Asia: insights from the Global Burden of Disease 2019 Study Intraocular foreign bodies (IOFBs) constitute a significant public health concern that hinders the accumulation of human capital in countries in Asia. This research aims to identify and project the time trend of the IOFB disease burden in Asia to 2035. Methods We utilised data collected from the Global Health Data Exchange (GHDx) query tool. Time Trends of disability-adjusted life years (DALYs) and incidence of IOFBs were calculated. Age- and gender-specific disease burden of IOFBs in 2019 was also analysed. A Bayesian age-period cohort (BAPC) model with integrated nested Laplace approximations (INLA) was applied to project the number and rate of the disease burden attributable to IOFB from 2020 to 2035. Results In Asia, the DALYs number increased from 290,521.62 (95% UI: 146,816.5–513,604.1) in 1990 to 388,363.39 (95% UI: 206,296.3–668,164.9) in 2019. The number of DALYs showed an upward trend until the age of 45–49 years, and then decreased in later age groups. The age-standardised incidence rate (ASIR) of China is projected to increase substantially from 719.03 in 2019 to 3127.06 in 2035. Singapore is projected to experience a slight decline, while the remaining six countries are projected to have slight, steady increases in ASIR. Conclusion Countries in Asia are facing...

Intraocular foreign bodies in Asia: insights from the Global Burden of Disease 2019 Study
->Nature | More on "Intraocular foreign body burden Asia" at BigEarthData.ai | #Disease #Health

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I know this isn't a #disease or mental illness. No, this is a violation of my mind. My memories have been erased. I don't know who I am or why I'm incarcerated in a space prison run by insect droids.

What crime landed me here? Thievery? Murder? Treason?

#SciFiFri
#WIP inspired

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Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cyt Multicystic mesothelioma (MCM) is an uncommon tumour arising from mesothelial cells [1,2,3,4,5,6]. It is almost always encountered in the peritoneum, where it accounts for about 3–5% of mesothelial tumours, but rare cases arising from the pleura have been described [7]. It can occur in both sexes and at any age, although women of child-bearing age are most often affected. The commonest locations are the lower abdomen and pelvis. Although many patients are asymptomatic, patients may complain of severe episodic pain, abdominal distention, urinary disturbances or constipation. Unlike other types of mesothelial neoplasm, the link between asbestos exposure and development of MCM remains uncertain. Macroscopically, the lesions are characterised by multiple thin-walled cysts of varying size, sometimes forming confluent masses 20 cm or more in diameter. Microscopy shows the cysts to have fibrous walls lined by cells exhibiting the histological and ultrastructural features of mesothelium [1, 3, 8, 9]. Treatment can include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in selected patients with good long-term outcomes [2, 8, 10]. The nature of multicystic mesothelioma has been controversial [6]. There is evidence that it is a true neoplasm: lesions can be progressive and recur after surgery, and in some cases the lesions are...

Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cyt
->Nature | More on "Multicystic mesothelioma genomic sequencing recurrence" at BigEarthData.ai | #Sequencing #Disease #Coronavirus #Mutation #BirdFlu #Health

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Nurse-Led #Digital Intervention for Sodium Restriction in Chronic Kidney #Disease: A Mixed-Methods #Study Mapping the #Patient Journey and Implementation Challenges Date Submitted: Feb 27, 2026. Open Peer Review Period: Mar 11, 2026 - May 6, 2026.

Reminder>> Nurse-Led #Digital Intervention for Sodium Restriction in Chronic Kidney #Disease: A Mixed-Methods #Study Mapping the #Patient Journey and Implementation Challenges (preprint) #openscience #PeerReviewMe #PlanP

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girl next to me pause squatting 325 for sets of four and when i gave her a 🤙 sign after a set she took her headphones off and said "thanks but my knees were caving" powerlifters are a #disease

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The #disease of white people has metastatized these last 4 decades since the sainted #Reagan & infested like vermin the thinking of all the lawless lying insurrectionist #Project2025 repugnicunt lawyers, & their white jesus houses of worship, & the laws in the white run repugnicunt flyover fiefdoms.

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Film 2431 - Jurassic World: Rebirth Intro : I'm in my movie era once again and lately I've been trying to catch up with all the films that I missed during last year or saved "...

#JurassicWorldRebirth is nom for 1 #Oscars:
• Visual Effects

#HollywoodCiak 2430 #JurassicWorld: #Rebirth #ScarlettJohansson #MahershalaAli #JonathanBailey #RupertFriend #ManuelGarciaRulfo #EdSkrein #scifi #dinosaur #blood #disease #DNA #JurassicPark
hollywoodciak.blogspot.com/2026/01/film...

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These diseases were thought to be incurable. Now AI is unlocking new treatments Artificial intelligence is rapidly inventing new drugs for diseases from Parkinson's disease and antibiotic-resistant superbugs to rare lung conditions.

These diseases were thought to be incurable. Now #AI is unlocking new treatments. #Artificial #intelligence is inventing new drugs against Parkinson's #disease, antibiotic-resistant superbugs and many rare diseases..
www.bbc.com/future/artic...
:Cat-AI

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Assessment and management of dry eye disease in the UK: standardising reality-based best practice Dry eye disease (DED), a multifactorial disease of the ocular surface involving loss of tear film homoeostasis and ocular surface inflammation [1, 2], can result in symptoms including discomfort and changes to vision [1, 3, 4]. DED affects around one third of the UK population [5]. The impact of DED on patients’ quality of life (QoL), both mental and physical, can be substantial [3, 4, 6,7,8], and the experience of moderate or severe disease has previously been compared to that of angina [9]. Furthermore, DED is associated with a substantial impact on productivity and work life, even for mild or moderate disease [8], with an increased risk of unemployment and a rate of absenteeism above the average [10]. Assessment of DED is complicated by the fact that signs and symptoms do not always correlate; notably, patients can present with debilitating pain associated with few clinical signs (termed neuropathic pain) [2, 4, 11]. Global guidance on the assessment and management of DED was developed by the Tear Film and Ocular Surface Dry Eye Workshop II (TFOS DEWS II) [1, 12, 13] and updated recently as DEWS III [2, 8, 14]; but international guidelines, however comprehensive, cannot fully reflect the realities of...

Assessment and management of dry eye disease in the UK: standardising reality-based best practice
->Nature | More on "Dry eye disease UK management" at BigEarthData.ai | #Disease #Health

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Improving preoperative enteral feeding for newborns with congenital heart disease The aim of this quality improvement project was to increase preoperative enteral feeding and breastfeeding rates in term neonates with congenital heart disease (CHD). Methods A multidisciplinary team developed and implemented a preoperative feeding protocol for neonates with congenital heart disease. The primary outcome was the presence of preoperative enteral feeding by May 2025. Secondary outcomes included breastfeeding rates and time to first feed. The process measure was the rate of reference to the feeding protocol in provider notes. Our balancing measure was a rule out or diagnosis of necrotizing enterocolitis requiring medical or surgical treatment in the preoperative period. Infants were identified using the Pediatric Cardiac Critical Care Collaborative (PC4). Data was collected from chart review and analyzed with statistical process control charts. The pre-implementation period was from June 2022 to June 2023, the implementation period was from July 2023 to June 2024, and the sustainment period was from July 2024 through May 2025. Results The number of neonates that met the inclusion criteria was 121. The rate of overall enteral feeding increased significantly from 72% in the pre-implementation phase (June 2022-June 2023) to 93% in the sustainment phase (July 2024–May 2025) (p = 0.026). Additionally, we found an...

Improving preoperative enteral feeding for newborns with congenital heart disease
->Nature | More on "Newborn heart disease feeding protocol" at BigEarthData.ai | #Disease #Health

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#Health
#Disease
#Death
#Grief
#Trauma
#Storms
#Cyclones
#Hurricanes
#Typhoons
#OceanHeat
#RapidIntensification
#Precipitation
#Floods
#Infrastructure
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

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observervoice.com/tropical-cyc...

#Storms
#Cyclones
#Hurricanes
#Typhoons
#OceanHeat
#RapidIntensification
#Precipitation
#Floods
#Health
#Disease
#Death
#Grief
#Trauma
#Infrastructure
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

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Yaks may hint at a way to treat brain diseases like MS A brain repair kit that helps yaks and other animals naturally cope with low oxygen levels at high altitudes may point to a new way to treat brain diseases such as multiple sclerosis. In mice with brain damage that mimics MS, the kit’s tools lessened signs of damage in young mice exposed to low oxygen and improved symptoms of MS in adult mice, researchers report March 13 in Neuron. Previous research found that animals living on the Tibetan Plateau, such as yaks and antelopes, carry a mutation in a gene called Retsat. Their lowland counterparts lack the mutation, leading scientists to suspect that it helps protect the brain in low-oxygen environments. “People usually think it’s because of better lung capability, but I wondered whether evolutionary adaptation changes the brain,” says Liang Zhang, a neuroscientist at Shanghai Jiao Tong University. In particular, he was intrigued that these animals have normal white matter in their brains. White matter makes up about half the brain; it consists of bundles of nerve fibers that allow different brain regions to communicate. This neural wiring is wrapped in myelin, a fatty substance that ensures nerve fibers conduct signals efficiently. In MS, the immune system attacks myelin,...

Yaks may hint at a way to treat brain diseases like MS
->Science News | More on "Yak gene inspires MS treatment" at BigEarthData.ai | #Disease #Health

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Pediatric bronchiolitis disease severity is associated with immune checkpoint dysregulation Bronchiolitis is a leading cause of lower respiratory tract infection in children under two years of age and is primarily associated with viral pathogens such as respiratory syncytial virus (RSV), influenza, and rhinoviruses.1 The disease exhibits a wide clinical spectrum, ranging from self-limiting symptoms to severe respiratory failure requiring pediatric intensive care, and is a major contributor to infant morbidity and mortality worldwide.2,3 Despite its prevalence, the immunopathogenesis of bronchiolitis remains incompletely understood, and predictive biomarkers for disease severity are lacking. Recent evidence highlights the critical role of immune dysregulation, particularly T cell–mediated responses, in bronchiolitis. Immune checkpoint molecules—such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and glycoprotein A repetitions predominant (GARP)—modulate T cell activation and maintain immune homeostasis. Aberrant regulation of these molecules has been implicated in various diseases but remains underexplored in bronchiolitis.4,5 Immune checkpoints have been extensively studied in oncology and chronic viral infections. Molecules such as CTLA-4 and programmed death-1 (PD-1) are targets of immunotherapy and are associated with immune exhaustion in infections like HIV and hepatitis B.6,7 Likewise, lymphocyte activation gene 3 (LAG-3) and TIM-3 have been shown to regulate the balance...

Pediatric bronchiolitis disease severity is associated with immune checkpoint dysregulation
->Nature | More on "Pediatric bronchiolitis immune checkpoint severity" at BigEarthData.ai | #Disease #Health

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Funding disease preparedness moves on, poultry depopulation bill postponed indefinitely States are preparing for the worst when it comes to highly pathogenic avian influenza and even New World screwworm. In Colorado, legislators are putting their money where their mouths are. The Diseased Livestock Indemnity Fund bill, sponsored by Reps. Karen McCormick, DVM, D-Longmont, and Ty Winter, R-Trinidad, and Sens. Byron Pelton, R-Sterling, and Dylan Roberts, D-Frisco, just passed its third reading in the Senate. Under current law, livestock owners may receive compensation from the Diseased Livestock Indemnity Fund after their herd is required to be sold for slaughter or destroyed because it was exposed to a contagious disease. The bill expands the allowable uses of the money in this fund to include preparing and responding to: • infectious or contagious diseases that pose a threat to livestock; and, • biological or chemical contaminants of animals that pose a threat to livestock. State Veterinarian Maggie Baldwin testified in favor of the changes before the Senate Ag and Natural Resources Committee last week. “In order to ensure that we’re adequately prepared and able to respond to the threats that could impact our food security, we need to have adequate resources including funding to build and maintain resilience against new and ongoing livestock...

Funding disease preparedness moves on, poultry depopulation bill postponed indefinitely
->The Fence Post | More on "Livestock disease preparedness funding legislation" at BigEarthData.ai | #Disease #Health

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They had it #cornered, a #disease so #specific it only killed folk in their 20s. The #effort to wipe it from the galaxy had the centre for galactic disease control asking: was it worth it? After all, people grow out of their 20s. Time to cut the #cord.

#scififri #vss365 #2wordprompt #vssdaily #sff

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Kidney #Transplantation in Patients With #Erdheim-#Chester #Disease

https://doi.org/10.1016/j.ekir.2025.103763

#KIRResearchLetter

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Prevalence and Patterns of Ocular Surface #Disease Among Glaucoma #Patients on Topical #Medications: A Prospective Comparative Cross-Sectional #Study #Protocol Date Submitted: Mar 7, 2026. Open Peer Review Period: Mar 9, 2026 - May 4, 2026.

Reminder>> Prevalence and Patterns of Ocular Surface #Disease Among Glaucoma #Patients on Topical #Medications: A Prospective Comparative Cross-Sectional #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

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Saudi Arabia's #Hospital Clustering and #Patient-Centered Care: A Mixed Methods Evaluation of Chronic #Disease Management under the Saudi #Health Sector Transformation Program Date Submitted: Mar 1, 2026. Open Peer Review Period: Mar 12, 2026 - May 7, 2026.

Saudi Arabia's #Hospital Clustering and #Patient-Centered Care: A Mixed Methods Evaluation of Chronic #Disease Management under the Saudi #Health Sector Transformation Program (preprint) #openscience #PeerReviewMe #PlanP

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