Diagram illustrating altered neurodevelopment in Huntington’s disease (HD) and proposed early interventions. The top row shows a healthy brain trajectory: wild-type huntingtin (wtHTT) supports normal development from a healthy developing brain to a healthy adult brain. The bottom row shows HD trajectory: presence of mutant huntingtin (mHTT) leads to an aberrant developing brain and later regional brain atrophy. Below, two intervention strategies to preserve developmental compensation are shown: Cell-autonomous approaches target stress response mechanisms (CHCHD2, DRP1, ATM, HSF1, other factors) to preserve mitochondrial health; Non-cell-autonomous approaches support intercellular communication, with compensation by cerebellum, healthy cells, and glial cells.
A new #DMMPerspective from Wenqing Xu & @aleprigio.bsky.social explores increasing evidence of #neurodevelopmental aspects in #HuntingtonsDisease & early interventions that might lead to prevention or delay of the disease pathology
journals.biologists.com/dmm/article/...
