#DNAbinding

Trends in Biochemical Sciences

@cp-trendsbiochem.bsky.social

1 month ago

📝Online now - the Forum "DNA binding is a defining feature of BRCA2 orthologs" from Alice Chanteau, Fabien Nogue, and Rajeev Kumar.

#BRCA2 #DNAbinding #homologousrecombination #DNArepair

Read it here 👉 authors.elsevier.com/a/1mTkq3S6Gf...

Engin Yapici

@enginyapici.bsky.social

2 months ago

RFdiffusion3: Atom-Level Protein Design at Scale Baker Lab released RFdiffusion3, an all-atom diffusion model for designing proteins that interact with DNA, ligands, and other…

RFdiffusion3: One DNA binder tested (5.89 µM affinity, no specificity controls). 35/190 enzymes active (no catalytically-dead mutants).

RFdiffusion1 had cryo-EM structures and nM binders. RFdiffusion2 had crystal structures and mutagenesis.

medium.com/@enginyapici...

#ProteinDesign #DNABinding

GetNews.me

@getnews-me.bsky.social

5 months ago

New SCOPE Tool Maps DNA‑Binding Proteins in Live Cells

SCOPE lets researchers target a genome locus, UV‑activate a crosslinker and capture nearby DNA‑binding proteins. In human embryonic stem cells it identified three proteins; work appears in PNAS. Read more: getnews.me/new-scope-tool-maps-dna-... #scope #dnabinding

iMeta Science

@imetascience.bsky.social

1 year ago

Specificity landscapes of 40 R2R3‐MYBs reveal how paralogs target different cis‐elements by homodimeric binding Closely related transcription factor (TF) paralogs are facing the “specificity paradox”—they share similar binding motifs, but their cis-regulatory targets and physiological roles can be different. B...

Specificity landscapes of 40 R2R3‐MYBs reveal how paralogs target different cis‐elements by homodimeric binding onlinelibrary.wiley.com/doi/full/10.... #DNAbinding