#DUX4

Francoise Helmbacher

@fhelmbacher.bsky.social

6 months ago

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophy - Skeletal Muscle Double Homeobox 4 (DUX4) is a potent transcription factor encoded by a retrogene mapped in D4Z4 repeated elements on chromosome 4q35. DUX4 has emerged as pivotal in the pathomechanisms of facioscapulo...

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophy

skeletalmusclejournal.biomedcentral.com/articles/10....

#FSHD, #DUX4, #Myoblue #SkeletalMuscle

Shifeng Xue

@shifengxue.bsky.social

6 months ago

Most drug discovery efforts for #FSHD target #DUX4 RNA or protein. We reviewed its upstream regulation. Epigenetic regulation of DUX4: From embryogenesis to muscular degeneration. sciencedirect.com/science/arti...

サードニュース@相互フォロー100%

@new3rd.bsky.social

7 months ago

顔面肩甲上腕型筋ジストロフィーにおける新たな治療の光明 顔面肩甲上腕型筋ジストロフィー（FSHD）のモデルマウスで、鉄代謝異常を介した新たな治療法の可能性が示唆されました。今後の研究に期待が寄せられています。

顔面肩甲上腕型筋ジストロフィーにおける新たな治療の光明 #熊本県 #熊本市 #フェロトーシス #顔面肩甲上腕型筋ジストロフィー #DUX4

顔面肩甲上腕型筋ジストロフィー（FSHD）のモデルマウスで、鉄代謝異常を介した新たな治療法の可能性が示唆されました。今後の研究に期待が寄せられています。

FSHD News

@fshd.bsky.social

1 year ago

👉SIX transcription factors are necessary for the activation of DUX4 expression in #fshd

💡Involvement of SIX transcription factors in the promotion of #DUX4 expression epigenetic derepression of the #D4Z4 repeats.

📰skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-...

FSHD News

@fshd.bsky.social

1 year ago

🇺🇸

👉Temporal variation in p38-mediated regulation of DUX4 in #FSHD

💡 p38 is critical for #DUX4 expression during early myogenesis

📰 pubmed.ncbi.nlm.nih.gov/39488616/

FSHD News

@fshd.bsky.social

1 year ago

🇺🇸
👉Temporal variation in p38-mediated regulation of DUX4 in #FSHD

💡 p38 is critical for #DUX4 expression during early myogenesis

📰 pubmed.ncbi.nlm.nih.gov/39488616/