Latest posts tagged with #Domainex on Bluesky
#biologicsdiscovery #drugdiscovery #Nuclera #SeriesCfunding #antibodyengineering #eProteinDiscoverysystem #eProteinDiscovery #AIenabledproteinengineering #biologicsdiscovery #membraneproteinworkflow #Cytiva #DNA #Domainex #CROimplementation #biologicsRandD
zurl.co/lO4B9
Check out our new blog, lnkd.in/esk6U9_h, by one of our scientists Alicia Overall, to find out about what the #Domainex team got up to at ELRIG.
The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.
Don't miss Jonathan Powell giving a presentation at the RSC BMCS New Approaches to the Treatment of Parkinson's conference.
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week, and up next is Nicholas Bland's poster.
Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG.
Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".
The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week.
First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".
FBLD Conference starts on Sunday in Cambridge and the #Domainex team are looking forward to attending.
Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.
At #Domainex, we are continuously expanding our computational chemistry toolkit to better guide molecular design and selection. Find out more in our latest blog:
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem
#Domainex will be attending Discovery on Target in Boston from the 22nd September. Come find Chris Miller and Andrew Ratcliffe at Booth 513 if you are attending.
Don't miss AJ's talk on 'Direct-to-Biology Enabled Drug Discovery' to find out more about our #D2B platform.
The #Domainex team are looking forward to attending the FBLD Conference later this month in Cambridge.
We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.
#Domainex is delighted to announce it has joined forces with Pharmacelera to accelerate the discovery of molecules targeting transmembrane proteins.
Find out more:
www.domainex.co.uk/news/domaine...
In our latest blog, you can find out more about the Trek to Remember hike for
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...
Congratulations to the two teams for completing the hike and raising over £4,000.
Are you thinking of pursuing a #prodrug strategy for your drug discovery programme? If so, get in touch with #Domainex to find out how we can help or take a look at our new webpage for more information:
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs
Are you looking for a new #ADME provider? #Domainex offer a wide range of assessments including:
- Physicochemical profiling
- Metabolic stability
- Permeability
Get in touch with our trusted experts through enquiries@domainex.co.uk to find out more about how we can assist you.
Are you looking for a new provider for your medicinal and synthetic chemistry? At #Domainex, we offer standalone synthesis services alongside our fully integrated offering, allowing you to drive your projects forward.
Get in touch with us at enquiries@domainex.co.uk to find out more.
Are you looking for a trusted partner for your #neuroinflammation drug discovery programme? If so, get in touch with us at #Domainex and we can connect you with our team of experts to help guide you. Our scientists can provide integrated services or assist you with the specific parts of your project
At #Domainex, we are always looking for ways to improve and update our services. We have expanded the scope of our #D2B platform by testing the compatibility of a range of #assay formats and reaction types. Find out more:
www.domainex.co.uk/services/dir...
Hayley French (CEO) and Ray Boffey (CCO) will be at ON Helix on Thursday.
Hayley French and Ray Boffey will be at ON Helix this Thursday. Catch up with them to find out about all the latest developments at #Domainex. They would be delighted to discuss how we can support your lead generation projects as your trusted partner.
#ONHelix #DrugDiscovery
Milner Therapeutics Symposium 2025: Meet Ray Boffey (CCO) and Emma Alexander (Commercial Operations and Lead Generation Scientist) there
#Domainex will be at the Milner Symposium on Monday. Catch up with Ray Boffey and Emma Alexander if you are there. They will be delighted to update you on the new developments at Domainex and discuss how we can support your lead discovery project with a personalised plan.
Domainex offers: Protein production and purification Established membrane protein purification platform High quality QC Cellular biology and molecular pharmacology cAMP modulation Ca2+ mobilisation β-arrestin recruitment, internalisation and trafficking Downstream signalling Mechanistic studies Biophysics Hit identification Hit-to-lead Lead optimisation
We have recently updated our #GPCR webpage. Take a look to see what's new:
www.domainex.co.uk/services/gpcrs
#Domainex #DrugDiscovery
Schematic mechanism of tri-complex formation and Elironrasib (RMC-6291). Generated from PDB: 9BFX
In our latest Medicinal Chemistry in Review blog, we highlight the discovery of Elironrasib (RMC-6291), published by Revolution Medicines .
domainex.co.uk/news/medicin...
#Domainex #DrugDiscovery #CovalentInhibitors
Are you developing covalent inhibitors? Get in touch with #Domainex to find out how our GSH reactivity assay can help.
We also offer a wide range of #ADME assays.
Get in touch with us at enquiries@domainex.co.uk to find out more and ask us about our introductory discounts.
If you are at#PEGSBoston this week, take a look at our poster (A030) on integral membrane proteins for #biophysics and cryo-EM.
Chris Miller will be there and is looking forward to discussing the poster, and the integrated drug discovery services that #Domainex can offer.
Image text says Cambridge Ion Channel Forum, Poster: Thursday 15th May, Integral Membrane Proteins for Biophysics and Cryo-EM Applications – Case Study of the Ion Channel TrpML3, Dr Natalie Winfield (Exec VP, Commercial Operations)
If you are at the Cambridge Ion Channel Forum this Thursday, take a look at our poster on integral membrane proteins for #biophysics and cryo-EM. Natalie Winfield will be there.
#Domainex #IonChannels #cryoEM #MembraneProteins
Image shows a photo of Hayley French with the words "Domainex Appoints Hayley French as Chief Executive Officer"
#Domainex is delighted to welcome Hayley French as our new CEO. Hayley is an accomplished attorney with a background in microbiology and significant experience in the life sciences sector.
See the full press release here:
www.domainex.co.uk/news/domaine...
Image text reads: EPSA is used to assess the permeability of compounds Particularly useful for assessing non-classical drug candidates, such as PROTACs® or cyclic peptides Compounds with LogP < 1 and EPSA < 100 typically demonstrate good permeability Alternative to cell-based assays such as Caco-2 or MDCK permeability assays
#Domainex can assess the Experimental Polar Surface Area (EPSA) of your compounds. The #EPSA assay is relatively fast and cost-effective compared to more complex in vitro or in vivo methods.
Find out more: www.domainex.co.uk/services/exp...
#Domainex are attending Drug Discovery Chemistry 2025 in San Diego next week (14th-18th April).
Ray Boffey and Chris Miller will be there and are looking forward to discussing how Domainex can help advance your lead discovery programmes.
Email enquiries@domainex.co.uk to arrange a meeting.
#Domainex are attending the 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets.
Jim Reid is attending and is looking forward to talking to you.
If you aren't attending but want to find out more , get in touch at enquiries@domainex.co.uk
#IonChannels25 #IonChannels
Text reads: At Domainex, our scientists are highly skilled and experienced in the design, synthesis and testing of both reversible and irreversible covalent inhibitors In-house covalent fragment library available Established workflows for both reversible and irreversible covalent fragments including: Mass-spectrometry (MS) based assay, Glutathione (GSH) reactivity assay (for irreversible inhibitors), Binding site identification by peptide mapping, Determination of the second order rate constant Kinact/Ki (for irreversible inhibitors), Determination of Kobs, maximum percentage of binding, and Koff rate (for reversible inhibitors), Structural biology characterisation
Do you need support for your #covalent inhibitor programme? Whether you need help identifying initial hits, optimising hits you've already identified, or profiling your covalent compounds, #Domainex has the expertise to drive your project forward.
www.domainex.co.uk/services/cov...
#FBDD
Text says: Wide range of service available: Project management including management of third-party resource (recommended by Domainex or your preferred provider). Consultancy: Target selection and validation, Assay trouble shooting, Druggability assessments, Evaluation of chemical matter, Support with grant applications, Assessment of assets for in-licencing, Photo of people in a meeting
#Domainex offers a wide range of project #management and #consultancy services. Whether you need someone to manage external resource on your behalf or help to trouble shoot your #assay, Domainex can help.
Find out more: www.domainex.co.uk/services/pro...
