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🔬ALPCO supports metabolic disease research with a broad portfolio of high sensitivity #immunoassays designed to measure key #biomarkers involved in #diabetes & #obesity

Explore ALPCO’s solutions for advancing #metabolic & #endocrine research: www.stratech.co.uk/our-partners...

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🔬ALPCO supports metabolic disease research with a broad portfolio of high sensitivity #immunoassays designed to measure key #biomarkers involved in #diabetes & #obesity

Explore ALPCO’s solutions for advancing #metabolic & #endocrine research: www.stratech.co.uk/our-partners...

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IOB, Now in issue!

State-Dependent and Social Modulation of Circulating #Glucocorticoids in a Nomadic #Songbird, the Red #Crossbill (Loxia Curvirostra)

(cover photo) Neil Paprocki
Vernasco et al

doi.org/10.1093/iob/...

#birds #biology #hormones #ecology #endocrine

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#pesticide #epigenetic #endocrine

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Author Meg Wilcox

Author Meg Wilcox

An #endocrine #disruptor found in widely used epoxy resins remains largely unregulated. We spoke with reporter @megwilcox.bsky.social about her prizewinning reporting on the topic, in #SEJournalInsideStory www.sej.org/publications... @sejorg.bsky.social @ejtodaynews.bsky.social

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Congratulations to Sara Abusara of @uniofaberdeen.bsky.social who was the winner of our prize draw at the Endocrine Metabolic GPCRs 2026 meeting in Liverpool, UK! 🎉

We loved meeting so many great life scientists this week and we look forward to seeing you all again next year! 👋

#endocrine #gpcr

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Learn the best ways to collect #saliva in adults, children or infants from the pioneers in #salivary #bioscience, #Salimetrics for accurate & reproducible #endocrine & #metabolic activity assessment & #diagnostics #cortisol #estradiol #progesterone

🔗www.stratech.co.uk/s...

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If you're at the Endocrine Metabolic GPCRs 2026 meeting in Liverpool, UK, this week, why not say 'hello' to Hello Bio! 👋

You'll find James in the exhibition space today and tomorrow - he looks forward to meeting you 😊

#endocrine #endocrinemetabolic #gpcr #GPCRs #endocrinology #metabolism

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Abstract Submissions Are Now Open!
15th Global Summit on Diabetes & Endocrine Disorders (GSDED 2026)
🗓️ July 22–23, 2026
📍 Tokyo, Japan
🔗 Submit your abstract now: diabetes.inovineconferences.com

#diabetesandendocrinedisorders2026
#globaldiabetessummit
#diabetestokyo2026
#endocrine

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Time to remind people to see or rewatch m.imdb.com/title/tt9071... 👍🏼A little enlightenment by Mark Gruffalo 'Dark Waters' .. #PFOA #PFAS
chemtrust.org/dark-waters-...
#TesticularCancer #endocrine disruptor. #environment Rob Bilott did meet with UKgov in 2020, but we know who was at the helm then

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Daniela Mello

“I find it absolutely mind-blowing that we can explore animal physiology through unconventional — and sometimes unexpected — biological samples.”




Xavier Glaudas

"My primary research interests lie in animal behavioral and evolutionary ecology. Over the years, my research has mainly revolved around animal foraging, mating systems, space use and defense."

Daniela Mello “I find it absolutely mind-blowing that we can explore animal physiology through unconventional — and sometimes unexpected — biological samples.” Xavier Glaudas "My primary research interests lie in animal behavioral and evolutionary ecology. Over the years, my research has mainly revolved around animal foraging, mating systems, space use and defense."

Meet more co authors of IOB's
Use of Nonconventional Sample Matrices for #Endocrine Studies of Pit #Vipers: Assay Validation and Applications
doi.org/10.1093/iob/...
Daniela Mello (@) danimellovet on Insta
&
Xavier Glaudas (@)glaudasx on Insta
read the image description

#snakes #science

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This is great news for reducing PFAS, an #endocrine disrupting chemical. New LDH material made from copper and aluminum that absorbs long-chain PFAS up to 100 times faster than commonly used charcoal water filtration systems.

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New Research Connections: How dkNET Allows Access to the Research Information Superhighway - Endocrine News Endocrine scientists around the world can now access dkNET, a research portal established by the National Institute of Diabetes and Digestive and Kidney Diseases, which provides endocrine researchers ...

Endocrine scientists around the world can now access @dknet.org, a research portal established by the NIDDK, which provides #endocrine researchers and clinicians with cross-disciplinary access to critical new information. #EndoSky

endocrinenews.endocrine.org/new-research...

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Understanding a species’ physiological state is important for advancing animal ecology and conservation. Endocrine responses to reproduction, stress, and nutritional status are commonly assessed through gonadal, adrenal, and thyroid hormones, respectively. Using nonconventional samples for endocrinological evaluation is an increasingly utilized method but remains uncommon for snakes. In this study, we assessed whether feces, urine, or shed skin from two Neotropical pit vipers (Bothrops jararaca and B. jararacussu) contain detectable testosterone (T), progesterone (P4), 17β-estradiol (E2), corticosterone (CORT), and triiodothyronine (T3) using enzyme immunoassay (EIA). We collected samples from 23 individuals, 10 B. jararaca and 13 B. jararacussu, and assessed detectability of hormones and/or immunoreactive hormone metabolites (IHM). We used tests of parallelism and accuracy to validate assays. Triiodothyronine was not detected in urine of either species; all other hormones were detected in all matrices. Testosterone and T3 showed good parallelism for all matrices tested. Parallelism tests for E2 (urine, both species), CORT (urine, B. jararaca, and shed skin, B. jararacussu), and P4 (urine, B. jararaca) showed marginally acceptable results. All accuracy validations were successful, except for T3 in shed skin extract (B. jararacussu) and P4 in urine extract (B. jararaca). This study demonstrates the applicability of nonconventional samples for hormone and IHM detection and quantification, offering valuable tools to monitor the endocrinological status of both free-ranging and confined snakes.

Understanding a species’ physiological state is important for advancing animal ecology and conservation. Endocrine responses to reproduction, stress, and nutritional status are commonly assessed through gonadal, adrenal, and thyroid hormones, respectively. Using nonconventional samples for endocrinological evaluation is an increasingly utilized method but remains uncommon for snakes. In this study, we assessed whether feces, urine, or shed skin from two Neotropical pit vipers (Bothrops jararaca and B. jararacussu) contain detectable testosterone (T), progesterone (P4), 17β-estradiol (E2), corticosterone (CORT), and triiodothyronine (T3) using enzyme immunoassay (EIA). We collected samples from 23 individuals, 10 B. jararaca and 13 B. jararacussu, and assessed detectability of hormones and/or immunoreactive hormone metabolites (IHM). We used tests of parallelism and accuracy to validate assays. Triiodothyronine was not detected in urine of either species; all other hormones were detected in all matrices. Testosterone and T3 showed good parallelism for all matrices tested. Parallelism tests for E2 (urine, both species), CORT (urine, B. jararaca, and shed skin, B. jararacussu), and P4 (urine, B. jararaca) showed marginally acceptable results. All accuracy validations were successful, except for T3 in shed skin extract (B. jararacussu) and P4 in urine extract (B. jararaca). This study demonstrates the applicability of nonconventional samples for hormone and IHM detection and quantification, offering valuable tools to monitor the endocrinological status of both free-ranging and confined snakes.

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IOB
Use of Nonconventional Sample Matrices for #Endocrine Studies of Pit Vipers: Assay Validation and Applications
de Souza ,
Mello ,
Glaudas ,
Hingst-Zaher ,
Almeida-Santos ,
Buck
doi.org/10.1093/iob/...

#snakes #science #conservation #hormones #academia #vipers

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Acanthosis Nigricans is a cutaneous maker of Gastric carcinoma #medicine #endocrine #dermatology

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Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor–Positive Breast Cancer: A Cohort S... PURPOSETo evaluate the clinical benefit of extended endocrine therapy (eET) after 5 years of adjuvant treatment with luteinizing hormone-releasing hormone agonists (LHRHa) in premenopausal women with ...

Extender terapia endocrina en pac premenopáusicas c/CA mama temprano y ganglios + luego de 5a de TTO c/agonista de hormona liberadora de hormona luteinizante se asocia c/reducción en las recurrencias de cáncer de mama invasivas y distantes #endocrine #breastcancer ascopubs.org/doi/abs/10.1...

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Circadian and sleep medicine: challenges and future directions for metabolic and endocrine research Circadian and sleep biology together define the temporal architecture of metabolic and endocrine physiology. Both the endogenous circadian clock and the homoeostatic drive for sleep regulate energy ba...

#Circadian & #sleep systems jointly shape #endocrine & #metabolic homoeostasis. Viewing them together as interacting dimensions of biological time offers a richer framework for understanding disease mechanisms & designing effective interventions www.thelancet.com/journals/lan...

#MedSky #EndoSky

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Reframing the sex debate in scientific research: three frameworks to support rigor without rigidity - Biology of Sex Differences Debates about the nature of sex are prominent in scientific, scholarly and public discourses. Scientific as well as societal debates largely focus on whether sex is appropriately conceptualized as a b...

This paper is da bomb - Reframing the sex debate in scientific research - three frameworks to support rigor without rigidity - Biology of Sex Differences. Thank you Stacey A. Ritz and @zacharydubois.bsky.social #MedSky #Endocrine #Biology #Bioscience #Psychology 😛🔥😻 link.springer.com/article/10.1...

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Selina M. Garcia et al. observed that acid-sensing #ion channel 1a deficiency drives #endocrine hypertension in male mice 🫀 🔬

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Have your work recognised within the global #endocrine community! Abstract submission for #ECE2026 will close on 20 January.

Submit your abstract today!
👉 ow.ly/jvHS50XBYB9

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Hypoparathyroidism vs Hyperparathyroidism: Causes, Symptoms...
#Hypoparathyroidism #Hyperparathyroidism #Endocrine #VikaasShandily #Hypocalcemia #Hypercalcemia

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Aberrant hormone receptors regulate a wide spectrum of endocrine tumors Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant express...

Regulation of #endocrine #tumours by aberrant GPCR is not restricted to cortisol-secreting adrenal lesions, but also occurs in tumours of several other organs www.thelancet.com/journals/lan...
G-protein coupled receptors #GPCRs

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Circuit diagrams and model equations for the hormone regulatory motifs. Diagrams are generic, stimulation and inhibition may be exchanged. h = hormone concentration,m=metabolite concentration, G = endocrine gland mass, u = input signal, r = rate constant for hormone removal, q = hormone/metabolite specific production rate (maximal secretion rate per unit biomass of secreting cell type), s = hormone sensitivity, a = rate constant for metabolite removal, c = cell proliferation/growth rate, d = cell death or removal rate.

Circuit diagrams and model equations for the hormone regulatory motifs. Diagrams are generic, stimulation and inhibition may be exchanged. h = hormone concentration,m=metabolite concentration, G = endocrine gland mass, u = input signal, r = rate constant for hormone removal, q = hormone/metabolite specific production rate (maximal secretion rate per unit biomass of secreting cell type), s = hormone sensitivity, a = rate constant for metabolite removal, c = cell proliferation/growth rate, d = cell death or removal rate.

The five classes of endocrine circuits and their dynamic response to brief and prolonged input stimuli. Diagrams are generic, and stimulation and inhibition may be exchanged. a−e Class 1−5, respectively. Metabolite, hormone and gland mass dynamics from simulations with a brief input pulse of 9 days (dashed blue line) or a prolonged pulse of 150 days and a second prolonged pulse with twice the amplitude at day 350 (orange line). Constant tissue in class 2 indicates that the secreting cell type growth is not regulated by elements in the circuit. The functions of the circuits are summarised. Simulation parameters are q = q3 = 16/day, q1 = 288/day, q2 = 48/day, rClasses1–3 = r3 = 16/day, r1 = 288/day, rClass4 = r2 = 48/day, c = c1 = c2 = d = d1 = d2 = 1/15/day, s = 48/day, a = 16/day.

The five classes of endocrine circuits and their dynamic response to brief and prolonged input stimuli. Diagrams are generic, and stimulation and inhibition may be exchanged. a−e Class 1−5, respectively. Metabolite, hormone and gland mass dynamics from simulations with a brief input pulse of 9 days (dashed blue line) or a prolonged pulse of 150 days and a second prolonged pulse with twice the amplitude at day 350 (orange line). Constant tissue in class 2 indicates that the secreting cell type growth is not regulated by elements in the circuit. The functions of the circuits are summarised. Simulation parameters are q = q3 = 16/day, q1 = 288/day, q2 = 48/day, rClasses1–3 = r3 = 16/day, r1 = 288/day, rClass4 = r2 = 48/day, c = c1 = c2 = d = d1 = d2 = 1/15/day, s = 48/day, a = 16/day.

Transition between subclinical and clinical Cushing’s syndrome cases for pituitary and adrenal tumours. a: Schematic showing how an adrenal cortisol-secreting tumour causes the native (non-neoplastic) adrenal cortex cortisol-secreting mass to shrink. Clinical disease appears in cases in which the adrenal cortex cortisol-secreting mass shrinks to zero. b: CRH, c: ACTH and d: cortisol as a function of adrenal tumour cortisol secretion rate β. e: Schematic showing how a pituitary ACTH-secreting tumour causes the native pituitary corticotroph mass to shrink. Clinical disease appears in cases in which the pituitary ACTH-secreting mass shrinks to zero. f: CRH, g: ACTH and h: cortisol as a function of pituitary tumour ACTH secretion rate α. Simulations used q1 = r1 =288/day , q2 = r2 = 48/day , q3 = r3 = 16/day, bP = aP = bA = aA = 1 15/day , r = 1/day, Kgr = 4, n = 3, K = 1, u = 1, and ζ = 0.1.

Transition between subclinical and clinical Cushing’s syndrome cases for pituitary and adrenal tumours. a: Schematic showing how an adrenal cortisol-secreting tumour causes the native (non-neoplastic) adrenal cortex cortisol-secreting mass to shrink. Clinical disease appears in cases in which the adrenal cortex cortisol-secreting mass shrinks to zero. b: CRH, c: ACTH and d: cortisol as a function of adrenal tumour cortisol secretion rate β. e: Schematic showing how a pituitary ACTH-secreting tumour causes the native pituitary corticotroph mass to shrink. Clinical disease appears in cases in which the pituitary ACTH-secreting mass shrinks to zero. f: CRH, g: ACTH and h: cortisol as a function of pituitary tumour ACTH secretion rate α. Simulations used q1 = r1 =288/day , q2 = r2 = 48/day , q3 = r3 = 16/day, bP = aP = bA = aA = 1 15/day , r = 1/day, Kgr = 4, n = 3, K = 1, u = 1, and ζ = 0.1.

#Endocrine feedback loops belong to the important foundations of life. However, consistent underlying rules are still lacking. Now, Moriya Raz, Uri Alon, and co-authors describe 5 classes of control circles.

www.livivo.de/doc/M41271754
pubmed.ncbi.nlm.nih.gov/41271754/
doi.org/10.1038/s414...

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Hormone Interaction Dynamics Network (HIDN) is a comprehensive framework, combining Graph Neural Networks (GNNs), Long Short-Term Memory (LSTM) networks, and external stimuli encoding to model hormone secretion, regulation, and inter-gland interactions. The model leverages graph-based representations to capture spatial dependencies among glands and employs recurrent neural structures to model temporal hormone dynamics. Integration of external factors, such as drug administration or environmental changes, is achieved through encoding mechanisms. Missing-signal prompts and generative prompts further enhance the model’s robustness in handling incomplete data. The overall system architecture ensures precise prediction of hormone concentration trends and adaptive response modeling in endocrine systems.

Hormone Interaction Dynamics Network (HIDN) is a comprehensive framework, combining Graph Neural Networks (GNNs), Long Short-Term Memory (LSTM) networks, and external stimuli encoding to model hormone secretion, regulation, and inter-gland interactions. The model leverages graph-based representations to capture spatial dependencies among glands and employs recurrent neural structures to model temporal hormone dynamics. Integration of external factors, such as drug administration or environmental changes, is achieved through encoding mechanisms. Missing-signal prompts and generative prompts further enhance the model’s robustness in handling incomplete data. The overall system architecture ensures precise prediction of hormone concentration trends and adaptive response modeling in endocrine systems.

Overview of the Adaptive Hormonal Regulation Strategy (AHRS), illustrating the integration of real-time hormonal monitoring and predictive feedback mechanisms, personalized risk-aware adaptation using bidirectional Mamba modules for pixel-level and feature-map analysis, and dynamic multi-objective optimization for intervention design to balance therapeutic efficacy and safety. The strategy continuously updates interventions based on hormone dynamics predictions and observed physiological responses, ensuring optimized, individualized endocrine management. The schematic highlights interactions among system components, emphasizing AHRS’s adaptability, predictive accuracy, and risk mitigation capabilities.

Overview of the Adaptive Hormonal Regulation Strategy (AHRS), illustrating the integration of real-time hormonal monitoring and predictive feedback mechanisms, personalized risk-aware adaptation using bidirectional Mamba modules for pixel-level and feature-map analysis, and dynamic multi-objective optimization for intervention design to balance therapeutic efficacy and safety. The strategy continuously updates interventions based on hormone dynamics predictions and observed physiological responses, ensuring optimized, individualized endocrine management. The schematic highlights interactions among system components, emphasizing AHRS’s adaptability, predictive accuracy, and risk mitigation capabilities.

A recent paper introduces a framework for modelling and analysing the interaction between #endocrine control systems and #EEG signals. It combines differential equations, neural networks, and machine learning.

www.livivo.de/doc/M40831955
pubmed.ncbi.nlm.nih.gov/40831955/
doi.org/10.3389/fend...

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🔬 Enhancing Salivary Bioscience with @salimetrics.bsky.social  
Supporting precision & consistency in #molecular, #endocrine & immunological research—in a single, powerful workflow
👉 Discover our complete line: https://www.stratech.co.uk/our-partners/salimetrics/
#Diagnostics #SalivaTesting

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