#Fumarate

@cp-trendsparasitol.bsky.social

7 months ago

Drs Franco Vairoletti, Cecilia Saiz & Gustavo Salinas discuss pharmacological targeting of the #helminth #complexII: are there any #rhodoquinone-driven adaptations? #Benzamide #Succinate #Dehydrogenase #Fumarate #Reductase #Hypoxia @ipmontevideo.bsky.social

authors.elsevier.com/a/1lRcz5Eb1x...

1 0 0 0

Hao Yin

@haoyin.bsky.social

8 months ago

#Fumarate update

Functional implications of fumarate-induced cysteine succination

Does Fumarase/FH1 deficiency (via either mitochondrial dysfunction, redox imbalance, or protein succination/inactivation) predispose #AorticAneurysm?🧐

#TrendsBiochem 2025
linkinghub.elsevier.com/retrieve/pii...

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Hao Yin

@haoyin.bsky.social

8 months ago

#Fumarate update

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation

Dual role in Inflammation

Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10

Pro-
mtDNA mtRNA➡️IFNβ

#CellMetab 2025
www.sciencedirect.com/science/arti...

21 4 0 0

Hao Yin

@haoyin.bsky.social

9 months ago

#Fumarate update

#FumarateHydratase inhibitor FHIN1 or induced KO in Macrophage ⏫chronic inflammation (LPS or SLE)-induced Interferon signal

⏫#MitochondrialMembranePotential➡️
⏫mtRNA➡️
TLR7 or RIG-I-MDA5 RNA sensors➡️
⏫IFNβ

Work in #Atherosclerosis?😁

@nature.com 2023
www.nature.com/articles/s41...

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Hao Yin

@haoyin.bsky.social

9 months ago

#Fumarate update

Oncometabolites (2-hydroxyglutarate, fumarate, succinate, mutations of IDH1/2, FH, SDHA/B/C/D)⏬ #HomologyDependentRepair #DNARepair & sensitize tumor cell to PARPi

Oncometabolites▶️
⏬ KDM4B▶️
Persistent H3K9me3 at DNA breaks▶️
⏬DNA repair

#Nature 2020
www.nature.com/articles/s41...

5 0 0 0

Hao Yin

@haoyin.bsky.social

9 months ago

#Fumarate update

Fumarate induces vesicular release of mtDNA to drive innate immunity

Global Fh1 #FumarateHydratase KO in adult🐭for 10 d➡️
⏫Kidney Fumarate, Inflammation w/o Immune cell infiltr

⏫cyto-mtDNA
➡️cGAS-STING
RIG-I too?🥸

@frezzalab.bsky.social #Nature 2023
www.nature.com/articles/s41...

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@emds2025.bsky.social

9 months ago

Speaker Highlight - Luke O'Neill

Delighted that @lukeanthonyoneill.bsky.social from @tcddublin.bsky.social will join us at www.emds2025.com. Looking forward to the #macrophage #metabolism masterclass already! #itaconate #fumarate & much more!

@britsocimm.bsky.social [Background photo:Chris Close]