🔬 Our 2026-2027 GI/Liver Fellowship is now accepting applications! #pathology #path2path #PathSky #Fellowship #GIPath #LiverPath
Apply Today! 👉 bit.ly/48GILxm
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#GIpath
Latest posts tagged with #GIpath on Bluesky
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Posts tagged #GIpath
🔬 Our 2026-2027 GI/Liver Fellowship is now accepting applications! #pathology #path2path #PathSky #Fellowship #GIPath #LiverPath
Apply Today! 👉 bit.ly/48GILxm
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Image of the Week!
Submitted by: Jacqueline Birkness-Gartman, M.D.
Directory Profile: www.pathologyoutlines.com/directory/ja...
Subspecialty: GI / liver
Diagnosis: Juvenile polyp
#Pathology #PathologyOutlines #GIPath #PathSky
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#slidearchiveseries history of nephrectomy for renal cell carcinoma, received immunotherapy with complete response, later developed upper GI bleeding from metastases to the proximal jejunum #gupath #gipath
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#publicationalert 🚨
α-SMA loss in the inner circular layer of jejunal muscle was common in both motility disorder cases and controls, making it an unreliable marker of dysfunction #gipath #pathsky
🔗 pubmed.ncbi.nlm.nih.gov/40328644/
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Extra cyto cases I put together for today👇
pathologynotebook.com/cytology-mod...
😊😊Enjoy!
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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✅Pancreatoblastoma
Acinar component indistinguishable from ACC
Swirling squamous morules (with nuclear β-catenin)
(+) Acinar (trypsin, BCL10) &/or neuroendocrine markers (synapto/chromo)
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
cyto Pancreatoblastoma
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Extra cyto cases I put together for today👇
pathologynotebook.com/cytology-mod...
😊😊Enjoy!
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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❌Neuroendocrine tumor
Monomorphic cells in loose aggregates, as single cells, and in pseudorosettes
Granular plasmacytoid cytoplasm
Salt-and-pepper chromatin & inconspicuous nucleoli (usually)
Many background stripped nuclei
Synaptophysin+, Chromogranin A+
#PathSky #Pathology #GIPath #CytoPath
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❌Acinar cell carcinoma
3D acinar ("grape-like") clusters
Polygonal cells with granular cytoplasm (i.e., zymogen)
Coarse chromatin, prominent nucleoli
Trypsin+ BCL10+
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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A cell block is made and an IHC is performed.
What IHC?
A) INSM1
B) β-catenin
C) CDX2
D) Synaptophysin
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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FNA of solid pancreatic head mass reveals large epithelioid cells in syncytial groups associated with smaller cells having prominent nucleoli.
What do these cells represent?
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
#PathSky #Pathology #GIPath #CytoPath
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Intramucosal adenocarcinoma in Barrett. Architectural complexity, nuclear atypia with large nucleoli, and poorly formed glands. p53 shows null staining pattern, suggestive of biallelic inactivation of TP53, leading to complete loss of expression. #PathSky #GIPath
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Extra cyto cases I put together for today👇
Module #6
pathologynotebook.com/cytology-mod...
😊😊Enjoy!
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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✅NETs show MEN1, ATRX, and DAXX alterations
RB1, TP53, SMAD4, and KRAS would suggest neuroendocrine carcinoma (NEC)
Synaptophysin+, Chromogranin A+
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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✅Neuroendocrine tumor (NET)
Monomorphic cells in loose aggregates, as single cells, and in pseudorosettes
Granular plasmacytoid cytoplasm
Salt-and-pepper chromatin & inconspicuous nucleoli (usually)
Many background stripped nuclei
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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❌Solid pseudopapillary neoplasm
Branching papillary fronds covered in monomorphic cells
Chromatin fine, not salt-and-pepper
Nuclear Beta-catenin+, CD10+
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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❌Pancreatoblastoma
Acinar component indistinguishable from ACC
Swirling squamous morules (with nuclear β-catenin)
(+) Acinar (trypsin, BCL10) &/or neuroendocrine markers (synapto/chromo)
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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❌Acinar cell carcinoma
3D acinar ("grape-like") clusters
Polygonal cells with granular cytoplasm (i.e., zymogen)
Coarse chromatin, prominent nucleoli
Trypsin+ BCL10+
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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Extra cyto cases I put together for today👇
Module #6
pathologynotebook.com/cytology-mod...
😊😊Enjoy!
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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(+) Chromogranin & (+) Synaptophysin indicate neuroendocrine differentiation.
Loss of which tumor suppressor gene best supports a well-differentiated neuroendocrine tumor?
A) RB1
B) MEN1
C) SMAD4
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
🔬 learn.mghpathology.org/index.php/WS...
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FNA of solid pancreatic head mass shows dispersed plasmacytoid cells.
What do you think these cells represent?
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
🔬 learn.mghpathology.org/index.php/WS...
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Extra cyto cases I put together for today👇
pathologynotebook.com/module-1
😊😊Enjoy!
#PathSky #Pathology #GIPath #CytoPath
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✅Neuroendocrine tumor
Monomorphic cells in loose aggregates, as single cells, and in pseudorosettes
Granular plasmacytoid cytoplasm
Salt-and-pepper chromatin & inconspicuous nucleoli (usually)
Many background stripped nuclei
✅Synaptophysin+, Chromogranin A+
#PathSky #Pathology #GIPath #CytoPath
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❌Solid pseudopapillary neoplasm
Branching papillary fronds covered in monomorphic cells
Chromatin fine, not salt-and-pepper
Nuclear Beta-catenin+, CD10+
#PathSky #Pathology #PathTwitter #GIPath #CytoPath
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0
1
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❌Pancreatoblastoma
Acinar component indistinguishable from ACC
Swirling squamous morules (with nuclear β-catenin)
(+) Acinar (trypsin, BCL10) &/or neuroendocrine markers (synapto/chromo)
#PathSky #Pathology #GIPath #CytoPath
0
0
1
0
❌Acinar cell carcinoma
3D acinar ("grape-like") clusters
Polygonal cells with granular cytoplasm (i.e., zymogen)
Coarse chromatin, prominent nucleoli
Trypsin+ BCL10+
#PathSky #Pathology #GIPath #CytoPath
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A cell block is made and an IHC shows cytoplasmic staining. What IHC is it?
A) synaptophysin
B) β-catenin
C) INSM1
D) CDX2
#PathSky #Pathology #GIPath #CytoPath
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FNA of solid pancreatic head mass.
What do these cells represent?🧐🧐
A) Acinar cell carcinoma
B) Neuroendocrine tumor
C) Pancreatoblastoma
D) Solid pseudopapillary neoplasm
#PathSky #Pathology #GIPath #CytoPath
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