Latest posts tagged with #GelCount on Bluesky
Milk sugars as neurodevelopment signals?
In human cortical organoids, pooled HMOs drove dose-dependent synaptogenesis and neurite outgrowth (50 μg/mL looked like a key threshold).
#GelCount imaging was used to capture precise post-treatment organoid diameters.
#Organoids #Neuroscience
New J Med Chem: first dual inhibitors of NAMPT and CA IX/XII (hypoxia-linked pH control). In 3D spheroids, compound 45 reduced cumulative spheroid area ~10× vs single-target controls.
#HypoxyLab enabled controlled hypoxia (1% O2) + #GelCount 2 enabled automated sizing.
#CancerResearch #Hypoxia
Some chemo sensitivity looks like a tipping point, not a slow slide.
Nature Cell Biology (2025) finds that knocking out PrimPol (replication restart) makes cisplatin much more toxic in SLFN11-high cells. Survival was validated with colony assays quantified on the #GelCount.
#CellBiology #Cisplatin
FBXO42 keeps PP4 phosphatase activity under control. In a new paper, FBXO42 loss boosts PP4R2-dependent effects and increases IR sensitivity.
Colony survival in Fig 1E/5B was quantified by imaging + counting adherent colonies with #GelCount.
#DNADamage #CellBiology #Oncology
What if drug-resistant lung cancer cells have a hidden control switch we can target to make treatments work again?
New pub show that blocking FAK plus EGFR drugs cuts long-term survival in colony assays, and was quantified with our #GelCount.
#LungCancer #DrugResistance
Is a single helper protein quietly keeping androgen receptor signaling alive in prostate cancer?
In a new @nature.com publication, a @ucsfcancer.bsky.social team identified PTGES3 as direct AR modulator using #CRISPR screens. Colony assays were analyzed by #GelCount, linking biology to cell fate.
What if blocking EXO1 could selectively kill FA/BRCA1-A/ZRSR2-deficient tumors?
New @nature.com study maps EXO1 synthetic-lethal partners and combo wins (PARPi, cisplatin, IR). Clonogenic survival imaged and analyzed with #GelCount across key figures (2-4).
#DNARepair #CancerResearch #Oncology
What if flipping CRC colony morphology could boost chemo?
New @nature.com paper shows azithromycin drives re-epithelialization in 3D collagen and sensitizes to irinotecan. Validations used #GelCount to objectively count 3D colonies.
#CancerResearch #3DCulture
www.nature.com/articles/s42...
What if ICL repair isn’t one pathway’s job?
DNA Repair (2025): NHEJ, TMEJ & HR co-contribute to crosslink repair, with dependencies shifting when NHEJ is impaired. Survival readouts (Fig. 1, 3, 4) were supported by #GelCount to image and analyze the clonogenic assays.
#DNARepair #GenomeStability
What if we’ve been aiming at the wrong surface?
Under <0.1% O₂, UPR drives intracellular C5aR1 that supports tumour cell survival — favouring cell-permeable inhibitors. #GelCount used to track 3D spheroid growth and to image/analyze clonogenic plates.
#Hypoxia #Spheroids #ClonogenicAssay
Are you really counting colonies, or just noise?
GelCount's multi-parameter object classification removes the guesswork—enabling clean, reproducible counts of colonies, spheroids, and organoids.
#Colony #Organoid #Spheroid #LabAutomation #GelCount #CancerResearch
New lung cancer research: BATF2-RGS2 axis drives T-cell exhaustion, limiting immunotherapy. RGS2↑ creates poor PD-1 response.
#GelCount automated colony counting validated 3D colonies (Supp Mat 3), enabling unbiased size/count analysis.
#Immunotherapy #LungCancer #CancerResearch #LabAutomation
Discover how #TemporalFractionation & #SpatialFractionation in microbeam radiation therapy (#MRT) enhances normal lung cell survival while maintaining tumor control in lung cancer models. #GelCount was used to make accurate survival curves.
#CancerResearch #RadiationTherapy doi.org/10.3390/biom...
