#HTRA1

DMM Journal

@dmmjournal.bsky.social

2 months ago

In October's #EditorsChoice, Kenneth Katschke, Marion Jeanne & co investigate the role of #HTRA1 in age-related retinal degeneration #AMD.

⚡ doi.org/10.1242/dmm....
📰 doi.org/10.1242/dmm....

Simon J. Clark

@prof-clark.bsky.social

5 months ago

The serine protease HTRA1 targets Tau fibrils and provides a proteolytic barrier against pathogenic protein conformations - PubMed Tauopathies such as Alzheimer's disease, frontotemporal dementia with Parkinsonism, and other neurodegenerative diseases are classified as protein folding diseases because they share amyloid fibrils…

New study shows #HTRA1 directly disrupts toxic #Tau fibril seeding: a breakthrough in understanding #Alzheimers and opening doors to novel #Neurodegeneration therapies. Understanding HTRA1 biochemistry may unlock what its doing in AMD too. buff.ly/KKyCtNi

Simon J. Clark

@prof-clark.bsky.social

6 months ago

HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization - PubMed Polymorphisms in the ARMS2/HTRA1 locus on chromosome 10 enhance the risk of geographic atrophy (GA) and macular neovascularization (MNV), the advanced forms of age-related macular degeneration (AMD).…

New research shows that HTRA1-driven proteolysis directly induces retinal degeneration in AMD, uncovering RBP3 as a novel substrate and potential therapeutic target. #AMD #HTRA1 #VisionResearch #TherapeuticTargets #Ophthalmology buff.ly/D9LsDVO

Simon J. Clark

@prof-clark.bsky.social

10 months ago

Besides, genetics is great for highlighting potential target pathways, but will never be the answer to therapeutic development - only understanding the Biochemistry of disease will achieve that! #AMD #HTRA1 #ARMS2 #drugdevelopment buff.ly/fT1gkNM

Simon J. Clark

@prof-clark.bsky.social

10 months ago

Machine learning based identification of anoikis related gene classification patterns and immunoinfiltration characteristics in diabetic nephropathy - PubMed Anoikis and immune cell infiltration are pivotal factors in the pathophysiological mechanism of diabetic nephropathy (DN), yet a comprehensive understanding of the mechanism is lacking. This work…

Interesting study on Anoikis in diabetic nephropathy shows HTRA1's positive correlation with immune cell recruitment and activation. What can this teach us about this ECM-protease's role in the blood/retinal barrier in AMD? #AMD #HTRA1 #anoikis buff.ly/Fbd1DR3

Simon J. Clark

@prof-clark.bsky.social

11 months ago

Publication on the phase II trial of Roche's now defunct anti-HTRA1 therapy in Geographic Atrophy secondary to AMD. It appears that the biological mechanisms affected by chromosome 10 genetic risk for AMD remain as elusive as ever. #HTRA1 #AMD #therapy

Simon J. Clark

@prof-clark.bsky.social

1 year ago

Genetic Distinctions Between Reticular Pseudodrusen and Drusen: A Genome-Wide Association Study - PubMed The study highlights a clear association between the ARMS2-HTRA1 locus and higher RPD load. Although the CFH locus association did not achieve genome-wide significance, a suggestive link was…

A deep learning AI analysis of over 160,000 OCT images finds reticular pseudodrusen density linked to ARMS2/HTRA1 gene variants. These pseudodrusen are different from classic drusen. Does this suggest ARMS2/HTRA1 genetic risk indicates a different type of AMD? #AMD #HTRA1 #ARMS2 buff.ly/ZdTvlxw