#IL18

@drimmuno29.bsky.social

4 months ago

🌤️ Still’s & MAS Biomarkers 🧬
🔥 IL-18 > 5000 pg/mL → hallmark; IL-18-dominant = MAS-prone, IL-6 = arthritis type.
Triad: IL-18 + S100 + Ferritin = max diagnostic power.
IFN-γ axis drives MAS — CXCL9 drop = response.
🎯 IL-18 defines Still’s; CXCL9 tracks MAS.
#BlueSkyRheum #ACR25 #MAS #IL18 #IFNgamma

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BERN-DERM

@bernderm.bsky.social

6 months ago

IL-18 in atopic dermatitis—a multifaceted driver of skin inflammation Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by pruritus, barrier dysfunction, and immune cell infiltration. Despite significant progress in our understanding of ...

🚀 Excited to share our new Review in @jacionline.bsky.social !
We summarize the current evidence on IL-18 in atopic dermatitis.

📊 Links to barrier dysfunction & disease severity
💡 Potential biomarker & therapeutic target

Read here 👉 www.jacionline.org/article/S009...

#IL18 #atopicdermatitis

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NYU Pain Research Center

@nyupainresearch.bsky.social

9 months ago

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells buff.ly/Jafo68c

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MargolisLab

@margolislabnyu.bsky.social

9 months ago

The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury | PNAS Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 ...

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...

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Bernard A. Fox

@bernardafox.bsky.social

1 year ago

3) Prof Renier Brentjens @roswellpark.bsky.social talks #Armored #CARs/ #IL18 & #IL36 impact in preclinical & led to clin trial design for #SCLC/ #BRIDGE2024 #adoptive #immunotherapy @alkpositiveuk.bsky.social @egfrpositiveuk.bsky.social @lungcancerresearch.bsky.social @lungcancer.bsky.social

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Bernard A. Fox

@bernardafox.bsky.social

1 year ago

2) Prof Renier Brentjens @roswellpark.bsky.social talks #Armored #CARs/ #IL18 & #IL36 impact in preclinical & led to clin trial design for #SCLC/ #BRIDGE2024 #adoptive #immunotherapy @alkpositiveuk.bsky.social @egfrpositiveuk.bsky.social @lungcancerresearch.bsky.social @lungcancer.bsky.social

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Bernard A. Fox

@bernardafox.bsky.social

1 year ago

Prof Renier Brentjens @roswellpark.bsky.social talks #Armored #CARs/ #IL18 & #IL36 impact in preclinical & led to clin trial design for #SCLC/ #BRIDGE2024 #adoptive #immunotherapy @alkpositiveuk.bsky.social @egfrpositiveuk.bsky.social @lungcancerresearch.bsky.social @lungcancer.bsky.social

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Mariana Marques, MD

@mcmarquesmd.bsky.social

1 year ago

NextGen Therapies for SJIA & MAS - 2024 - Systemic Juvenile Idiopathic Arthritis Foundation NextGen Therapies in SJIA, Still’s & MAS Organized by: Systemic JIA Foundation Where: Washington DC – Royal Sonesta Hotel, Dupont Circle. When: From Wed, Nov 13th (evening) to Fri, Nov 15th (noon)...

Super excited for the beginning of the NextGen Therapies for #SJIA and #MAS meeting!
Opening lectures today discussing the role of #IL18!

www.systemicjia.org/nextgen24/

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Posts tagged #IL18