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πŸ” #SABCS2025: #INSEMA Trial – #Radiotherapy Analysis (presented by Guido Hildebrandt)
Today’s presentation offered important insights into how radiotherapy was actually applied among patients undergoing breast-conserving surgery with or without sentinel lymph node biopsy #SLNB in the INSEMA trial.

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#SABCS2025 Update: #INSEMA – Secondary results presented by Toralf Reimer

INSEMA Rando2 adds robust data on the oncological #safety of omitting cALND in patients with positive SLNB, under conditions of strict regional nodal irradiation #RNI and #radiotherapy quality assurance.

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PinkOctober – Research Brings Hope: #INSEMA Study #GBG75

πŸ“– Most recent results have been published in #NEJM: www.nejm.org/doi/full/10....

Exciting news: the latest INSEMA data will be presented as an Oral Presentation at the San Antonio Breast Cancer Symposium #SABCS2025 this December.

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Photo of the speaker on the SABCS-podium.

Photo of the speaker on the SABCS-podium.

Final primary results of the #INSEMA trial presented at #SABCS24: de-escalating surgical interventions for patients with early invasive #BreastCancer undergoing breast-conserving surgery.
Download the presentation: www.gbg.de/en/news/deta...
Read full @nejm.org paper: www.nejm.org/doi/full/10....

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5. #INSEMA: 🚫 of axillary βœ‚οΈ for SLNBx w/ clinically N-ve invasive breast cancer staged T1/T2 (≀5 cm) scheduled to undergo breast-conserving surgery.

- 5yr iDFS 91.9% without βœ‚οΈ vs 91.7%
- Omission of surgical axillary staging was noninferior to SLNBx

6/6

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#SABCS24 Day 3 Highlights #CommunityOnc:

1. #EUROPA: ET vs XRT HR+ β‰₯70 yrs

2. #PATINA: CDK4/6 HR+ HER2+ new SoC

3. #COMET: DCIS

4. #SUPREMO: XRT post mastectomy

5. #INSEMA: ALNBx

@sabcs.bsky.social @theaacr.bsky.social
@drsarahsammons.bsky.social
@erikahamilton9.bsky.social

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Quick take from Dr Mridula George re the newly presented #INSEMA data (SLN sampling omission)- a med onc perspective @sabcs.bsky.social #SABCS @drgattimays.bsky.social

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GS3 - #LessIsMore πŸ‘ #INSEMA trial shows can OMIT nodal sampling in cN0 patients (preop Ax US) with G1/G2, ER+/HER2- tumors 2cm or less preop undergoing BCS and postop RT πŸ”‘ Point - No difference in OS, iDFS @drgattimays.bsky.social @osuwexmed.bsky.social

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