#InfectLU

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2 months ago

Creation and validation of improved MALDI-TOF MS libraries for S. bovis-S. equinus-complex subspecies identification adapted to diagnostic culturing and extraction conditions Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) libraries have limited capabilities for identification of …

New from Nilson’s group: Öberg et al. create and validate improved MALDI-TOF MS libraries for identifying subspecies of the S. bovis-S. equinus complex.

#InfectLU #Diagnostics #MassSpec led by B. Nilson

www.sciencedirect.com/science/arti...

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Infect@LU

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2 months ago

Characterization of five environmental phages infecting Escherichia coli K-12 isolated during a phage biology training course | Microbiology Spectrum Bacterial anti-phage defense systems are central to microbiology and have applications in biotechnology and medicine. Phage collections are key tools for uncovering and studying these systems. By isol...

New article: Shyrokova et al. isolate and characterize five environmental phages infecting E. coli K-12. A detailed look at phage genomics and host interactions from a phage biology training course.

#InfectLU #Phages #Microbiology led by M. J. O. Johansson

journals.asm.org/doi/10.1128/...

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2 months ago

Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states - Nature Communications Marín-Arraiza and colleagues report the cryo-EM structures of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states, providing structural insigh...

New from Taylor’s group: Marín-Arraiza et al. characterize the structure of an extracellular contractile injection system from Photorhabdus luminescens.

#InfectLU #StructuralBiology #CryoEM led by N. M. I. Taylor

www.nature.com/articles/s41...

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@infect-lu.bsky.social

2 months ago

Citrobacter spp. bloodstream infection primarily affects the elderly either hospitalized or closely associated with health care – a population-based observational study with comparisons between C. kos... Objectives Despite regularly being found in blood cultures, there are few studies of bloodstream infection (BSI) with Citrobacter. In this population-based study, the aim was to explore patient charac...

New: Sunnerhagen et al. find Citrobacter bloodstream infections primarily affect the elderly with healthcare contact. C. koseri is linked to urinary sources, while C. freundii often has an abdominal focus. #InfectLU #Bacteriology #Epidemiology led by O. Ljungquist

link.springer.com/article/10.1...

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2 months ago

Sacrificial redox modulation by a secreted bacterial effector molecule mitigates oxidative stress and inflammation in vivo Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensa…

New from Lood’s group: Andersson et al. reveal that a secreted bacterial effector from P. acnes acts as a sacrificial redox modulator, mitigating oxidative stress and inflammation in vivo.

#InfectLU #SkinMicrobiome #Inflammation led by R. Lood

www.sciencedirect.com/science/arti...

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3 months ago

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

New from Atkinson’s group: Odai et al. present the Viral AlphaFold Database, revealing conserved protein folds in viruses across bacteria, archaea, and eukaryotes. A massive step for structural virology.

#InfectLU #Virology #AI led by G. C. Atkinson

www.science.org/doi/10.1126/...

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3 months ago

Overcoming Immune Evasion in Staphylococcus aureus: Strategies for Rational Vaccine Design Staphylococcus aureus remains one of the most elusive targets in bacterial vaccinology, primarily due to its complex immune evasion strategies and the phenomenon of immune imprinting. Despite decades ...

New from Converso’s group: Shinwari et al. review strategies to overcome S. aureus immune evasion for rational vaccine design. The paper proposes a framework using AI and omics to identify effective antigens.
#InfectLU #Vaccines #Staphylococcus led by T. R. Converso

pubs.acs.org/doi/10.1021/...

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3 months ago

New article: Forsberg et al. share peptidomics data from porcine wound infections—resources for host–pathogen research, led by Hartman.

doi.org/10.1038/s415... #InfectLU #Proteomics

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4 months ago

Redirecting

New article: Öhrneman et al. benchmark nano‑PSL aerosol generators & toxicity; NAG shows stability—led by Löndahl.

doi.org/10.1016/j.ja...

#InfectLU #Nanoparticles

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4 months ago

The cystic fibrosis pathogen Achromobacter xylosoxidans inhibits biofilm formation of Pseudomonas aeruginosa Background. Achromobacter xylosoxidans and Pseudomonas aeruginosa are two pathogens that cause persistent airway infections in individuals with cystic fibrosis (CF). The persistence of P. aeruginosa i...

The cystic fibrosis pathogen Achromobacter xylosoxidans inhibits biofilm formation of Pseudomonas aeruginosa

New article: Sahl et al. show A. xylosoxidans can inhibit P. aeruginosa biofilms in vitro—led by Påhlman. doi.org/10.1099/jmm.... #InfectLU #Biofilms

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4 months ago

Septic arthritis score (SAS) – a novel clinical prediction model for the probability of septic arthritis in the adult native knee - BMC Infectious Diseases Background Patients presenting with an acutely painful swollen joint represent a diagnostic challenge. We aimed to develop a clinical prediction model for septic arthritis (SA) in the adult native kne...

New article: Tverring et al. introduce SAS to estimate native knee septic arthritis risk—online calculator included—led by Ljungquist.
doi.org/10.1186/s128... #InfectLU #Diagnostics

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5 months ago

New article: Silva et al. validate a GFP‑based proxy for antibiotic‑induced phage activation in E. coli—led by Lood. doi.org/10.3390/anti... #InfectLU #Phage

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5 months ago

New article: Litins’ka et al. examine infection control vs. freedom of movement in Swedish elder care.

doi.org/10.53292/061... #InfectLU #HealthLaw

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5 months ago

Spread of the FAR-MRSA clone, a fusidic acid- and meticillin-resistant Staphylococcus aureus ST121, Europe, 2014 to 2024 We describe the genetic characteristics of a fusidic acid- and meticillin-resistant Staphylococcus aureus (MRSA) clone widespread in Europe, based on whole genome sequences from 317 isolates. The clone is causing impetigo and other skin and soft tissue infections, primarily in young children. Comparison with publicly available S. aureus ST121 sequences showed that the clone is clearly distinct from previously described ST121 clones. European and other international readers should be aware of the emergence of this community-acquired MRSA clone.

New letter: Roer et al. report spread of FAR‑MRSA ST121 across Europe, affecting children—led by Petersen.

doi.org/10.2807/1560... #InfectLU #MRSA

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5 months ago

New article: Öberg et al. deliver MALDI‑TOF libraries enabling near‑universal SBSEC subspecies ID in routine workflows—led by Nilson.
doi.org/10.1016/j.di... #InfectLU #Diagnostics

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