#LegacyContent

Gut Microbiome and Bile Acid Interactions Cholangiocarcinoma (CCA) is a rare but highly malignant carcinoma of bile duct epithelial cells with a poor prognosis. The major risk factors of CCA carcinogenesis and progression are cholestatic live...

4 days ago

#LegacyContent: Gut Microbiome and Bile Acid Interactions: Mechanistic Implications for #Cholangiocarcinoma Development, Immune Resistance, and Therapy.

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Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes Current clinical testing approaches for individuals with suspected imprinting disorders are complex, often requiring multiple tests performed in a stepwise manner to make a precise molecular diagnosis...

6 days ago

#LegacyContent: Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes.

Free in the #OpenArchive: www.jmdjournal.org/article/S152...

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Predicting Consanguinity Rates from Exome Sequencing Data in the Lebanese Population Consanguinity, prevalent in certain populations because of cultural and social factors, significantly increases the risk of genetic autosomal recessive disorders. In Lebanon, consanguineous marriages ...

1 week ago

#LegacyContent: Predicting Consanguinity Rates from Exome Sequencing Data in the Lebanese Population.

Free in the #OpenArchive: www.jmdjournal.org/article/S152...

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Development and Validation of a Rapid Point-of-Care CYP2C19 Genotyping Platform Pharmacogenetic-guided prescribing can lead to more accurate medicine selection and dosing, improving patient outcomes and leading to better use of health care budgets. Loss-of-function variants in CY...

1 week ago

#LegacyContent: Development and validation of a rapid point of care CYP2C19 genotyping platform.

#OpenAccess text: www.jmdjournal.org/article/S152...

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2 weeks ago

#LegacyContent: Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(25)00...

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Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization Tumor-associated macrophages (TAMs) play dual roles (both pro- and antitumor) in tumor progression. TAMs induce programmed death ligand-1 (PD-L1) expression in cancer cells. However, the regulatory ef...

3 weeks ago

#LegacyContent: Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization.

#OpenArchive: ajp.amjpathol.org/article/S000...

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3 weeks ago

#LegacyContent: Multi-Class Segmentation Network Based on Tumor Tissue in Endometrial Cancer Pathology Images: ECMTrans-net

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Analytical and Clinical Validation of the Plasma-Based Guardant360 CDx Test for Assessing HER2 (ERBB2) Mutation Status in Patients with Non–Small-Cell Lung Cancer for Treatment with Trastuzumab Deruxt... This study demonstrates the analytical and clinical validity of the approved (United States and Japan) plasma-based Guardant360 companion diagnostic (CDx) test for selecting patients with human epider...

3 weeks ago

#LegacyContent: Analytical and Clinical Validation of the Plasma-Based Guardant360 CDx Test for Assessing HER2 (ERBB2) Mutation Status in Patients with Non–Small-Cell Lung Cancer for Treatment with Trastuzumab Deruxtecan in DESTINY-Lung01/02.

#OpenArchive: www.jmdjournal.org/article/S152...

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Segmental Regulation of Intestinal Motility by Colitis and the Adaptive Immune System in the Mouse Ileum and Colon Gastrointestinal motility disturbances are a hallmark of inflammatory bowel disease (IBD); however, their mechanisms remain unclear. This study used a dextran sulfate sodium–induced colitis mouse mode...

1 month ago

#LegacyContent: Segmental Regulation of Intestinal Motility by #Colitis and the Adaptive Immune System in the Mouse Ileum and Colon.

ajp.amjpathol.org/article/S000...

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Validation and Performance of Quantitative BRCA1 and RAD51C Promoter Hypermethylation Testing in Breast and Ovarian Cancers Poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors represent a significant advancement in the treatment of epithelial ovarian cancer, triple-negative breast cancer, pancreatic cancer, an...

1 month ago

#LegacyContent: Validation and Performance of Quantitative BRCA1 and RAD51C Promoter Hypermethylation Testing in Breast and Ovarian Cancers.

#OpenArchive: www.jmdjournal.org/article/S152...

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Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53 Alterations in miRNAs, p53, and sphingolipid metabolism are associated with head and neck squamous cell carcinoma (HNSCC). However, the role of sphingosine kinase (SK)-2, an enzyme crucial for sphingo...

1 month ago

#LegacyContent: Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53. Authors from University of São Paulo.

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1 month ago

#LegacyContent: Single-Cell Advances in Investigating and Understanding Chronic Kidney Disease and Diabetic Kidney Disease

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2 months ago

#LegacyContent: Single-Cell Analysis Provides New Insights into the Roles of Tertiary Lymphoid Structures and Immune Cell Infiltration in Kidney Injury and Chronic Kidney Disease.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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2 months ago

#LegacyContent: Spatial transcriptomics: Integrating morphology and molecular mechanisms of kidney diseases.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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2 months ago

#LegacyContent: SARCP, a Clinical Next-Generation Sequencing Assay for the Detection of Gene Fusions in Sarcomas.

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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2 months ago

#LegacyContent: The Kidney Precision Medicine Project and Single-Cell Biology of the Injured Proximal Tubule

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2 months ago

#LegacyContent: Considerations for Severe Acute Respiratory Syndrome Coronavirus 2 Genomic Surveillance: A Joint Consensus Recommendation of AMP and APHL.

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4 months ago

#LegacyContent: Tailored digital PCR follow-up of rare fusion transcripts after initial detection through RNA-sequencing in hematological malignancies. Authors from @chugrenoblealpes.bsky.social

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4 months ago

#LegacyContent: Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea.

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4 months ago

#LegacyContent: Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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4 months ago

#LegacyContent: Artificial Intelligence-Based Histopathological Subtyping of High-Grade Serous #OvarianCancer.

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4 months ago

#LegacyContent: Characterization of Reference Materials for DPYD: A GeT-RM Collaborative Project. Authors from @research.childrensmercy.org @mayoclinic.org

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4 months ago

#LegacyContent: Sequential Patching Lattice for Image Classification and Enquiry: Streamlining Digital Pathology Image Processing. Authors from @mayoclinic.org.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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4 months ago

#LegacyContent: The Role of Twist1 in Chronic Pancreatitis–Associated Pancreatic Stellate Cells. Authors from @cedarssinaicancer.bsky.social.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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4 months ago

#LegacyContent: Lactate Contributes to RIPC–Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase–Mammalian Target of Rapamycin–Transcription Factor EB–Connexin 43 Axis.

https://loom.ly/4ofKbWc

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4 months ago

#LegacyContent: Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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4 months ago

#LegacyContent: Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype. @dalhousie.bsky.social

#OpenAccess text: ajp.amjpathol.org/article/S0002-9440(24)00...

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4 months ago

#LegacyContent: Analytical Validation of an Early Detection Pancreatic Cancer Test Using 5-Hydroxymethylation Signatures. From authors at @clearnotehealth.bsky.social.

#OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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