Latest posts tagged with #MALMs on Bluesky
In conclusion, our hydrogel-based spatiotemporal control strategy of physicochemical biocontainment reduces a critical barrier to deploying #ELMs
What are remaining challenges? Achieving suspension culture comparable metabolic activity and further extension of cell retention in #ELMs / #MALMs 🧪
A schematic showing comparative metabolic activity of suspension cultures and ELMs with physicochemical biocontainment. Source: https://doi.org/10.26434/chemrxiv.10001975/v1
How about the metabolic activity in #ELMs?
We found ~40% increase in fermentation in MAA-containing #MALMs
Cell retention and metabolic activity increases are significant for such applications as releasing drug molecules over time using living therapeutics materials or biocontained bioreactors
A four panel graphic showing macroscopic view of engineered living materials. Source: https://doi.org/10.26434/chemrxiv.10001975/v1
What did we find in our experiments?
We found that MAA-containing #ELMs enable tunable biocontainment of yeast after immersion in 70 vol.% ethanol, leading to the formation of a time-dependent cell-free zone
The resulting yeast-laden #MALMs show cell retention of ~ 100 h vs ~ 24 h in controls
While doing 3D printed brewery project we realized that though we can create #MALMs, cells escape from 3D printed matrices in ~ 24 h
Hence the motivation of new preprint - to improve the cells retention and metabolic activity in #ELMs / #MALMs
Excited to share our @chemrxiv.org preprint on metabolically active living materials #MALMs with physciochemical biocontainment🧵
Why do we need #MALMs?
Because as @economist.com posits additive manufacturing is potentially a better way to make drinks and drugs
We argue #MALMs are the key for it
