#MITF

Molecular Biomedicine

@mol-biomed.bsky.social

4 months ago

MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors - Molecular Biomedicine The role of Microphthalmia-associated Transcription Factor (MITF) in gastrointestinal stromal tumors (GISTs) remains unclear, although previous studies suggest it contributes to tumor growth regulatio...

#Research
MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors doi.org/10.1186/s435...

#MITF #ChIPseq #Autophagy #ExtracellularVesicle #GIST

Sandra Iden

@sandraiden.bsky.social

5 months ago

… and we are very happy that our study on extrinsic control of melanocyte functions is published - kudos to @caroleluthold.bsky.social & co-authors! We found that distinct #ECM components impinge on #MITF, #melanocyte differentiation & #mechanosensation. Find out more here: doi.org/10.1038/s443...

EMBO Reports

@emboreports.org

5 months ago

Sandra Iden @sandraiden.bsky.social @idenlab.bsky.social @uni-saarland.de @pharmascihub.bsky.social and co-workers show that #melanocyte #differentiation and #mechanosensation are differentially modulated by distinct extracellular matrix proteins. #ECM #MITF

www.embopress.org/doi/full/10....

Xin Lai

@xin-lai.bsky.social

8 months ago

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcript....

We reconstruct a complex #microRNA network that cross-talks with #SOX10 and #MITF to regulate #tumor plasticity. Network analysis shows miRNA-mediated circuits control signaling pathways - driving phenotype switching, stemness & therapy resistance in #melanoma.
doi.org/10.1002/ijc....