#MolCell

Hao Yin

@haoyin.bsky.social

4 months ago

Epitranscriptomics #PhaseSeparation

m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate

MINT-seq detects >3-fold more m6A peaks than MeRIP-seq

Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)

#MolCell 2021
www.cell.com/molecular-ce...

@labsantoro.bsky.social

9 months ago

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

Hao Yin

@haoyin.bsky.social

1 year ago

#Centromere #Aging

"Centromeric transcription & CENP-A/C is epigenetically downregulated in Aging"

H3K9me3⏫ H3K4me2⏬on centromere/pericentromeric DNA
Rescued by p53 siRNA + KDM1A inhibitor➡️⏫genomic stability & mitotic fidelity of aged fibroblast

#MolCell 2025
www.sciencedirect.com/science/arti...

Pedro Friedmann Angeli

@angelifriedmann.bsky.social

1 year ago

Published in the current edition of #MolCell ours and Marcus Conrad group study made the cover 🤩

Different biology converging on the newly identified role of #Prdx6 acting as a selenium carrier protein

🌕🌖🌗🌘🌑🌒🌓🌔🌕