#NatCommun

Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer’s disease #NatCommun #MassSpec www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics - Nature Communications Several recent publications have attempted to detect novel unannotated microproteins using mass spectrometry proteomics. Here, the authors reassess these claimed microprotein detections, finding that ...

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations - Nature Communications Asthma exacerbations remain hard to predict with routine tests. Here, the authors show that simple blood sphingolipid-to-steroid ratios predict five-year exacerbation risk and can underpin a practical...

The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations #NatCommun #MassSpec www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial - Nature Communications Increasing dietary carbohydrate-to-fat ratio in a randomized controlled feeding study altered circulating small molecules (metabolites), including ones associated with diabetes risk, underscoring impo...

Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial #NatCommun #MassSpec www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

A practical method for determining the rate of covalent modification of fragments and leads - Nature Communications In this work, Jeon et al. introduce the diagonal dose-response time-course (dDRTC), a fast and operationally simple mass spectrometry-based method for determining the efficiency of covalent modificati...

A practical method for determining the rate of covalent modification of fragments and leads #NatCommun #MassSpec www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

Enantioselective protein affinity selection mass spectrometry (E-ASMS) - Nature Communications High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand d...

Enantioselective protein affinity selection mass spectrometry (E-ASMS) #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry - Nature Communications Archaeal membrane lipids have distinct structures but lack comprehensive databases for high-throughput identification. Here, authors present ArchLips, a database containing over 219,348 in silico stru...

A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry #NatCommun www.nature.com/articles/s41...

2 1 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

De novo sequencing of glycans by ion mobility-mass spectrometry using a self-expanding database - Nature Communications This study introduces an ion mobility–mass spectrometry method for de novo glycan structure identification, using a self-expanding database that reduces reliance on synthetic reference standards.

De novo sequencing of glycans by ion mobility-mass spectrometry using a self-expanding database #NatCommun www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Cysteine-enabled cleavability to advance cross-linking mass spectrometry for global analysis of endogenous protein-protein interactions - Nature Communications Cysteine oxidation transforms non-cleavable heterobifunctional lysine-cysteine cross-linked peptides into MS-cleavable ones, enabling their unambiguous identification at the systems level. Here, using...

Cysteine-enabled cleavability to advance cross-linking mass spectrometry for global analysis of endogenous protein-protein interactions #NatCommun www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra - Nature Communications Chemical formula identification from mass spectrometry data is challenging for large molecules. Here, the authors develop FIDDLE, a deep learning method that achieves 88.3% accuracy in predicting mole...

FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra #NatCommun #MassSpec www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity - Nature Communications Chromatin structure is regulated by chemical modifications of histone proteins, but measuring these at single-cell resolution has been challenging. Here, the authors develop a mass spectrometry-based ...

Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity #NatCommun www.nature.com/articles/s41...

2 0 0 0

SciOpen

@sciopentup.bsky.social

3 months ago

Strong work shared by @shihcheng.bsky.social , identifying CLCC1’s role in HSV-1 egress pushes forward host-factor–based antiviral strategies.
Find more studies on SciOpen: www.sciopen.com
#MolecularBiology #CRISPRScreening #NatCommun #BiomedicalScience

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models - Nature Communications Amyloid plaques are a hallmark of Alzheimer’s disease. Better understanding of their biochemistry can inspire new biomarkers and therapeutics. Using multimodal mass spectrometry imaging, this work rev...

Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases - Nature Communications Breastfeeding is inversely associated with cardiometabolic disease; however, the metabolic pathways underlying these associations remain largely unknown. Here, the authors show plasma metabolite profi...

Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases #NatCommun #MassSpec www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity - Nature Communications The proteasome is essential for protein degradation, but its complexity can be lost in vitro. Here, the authors use in-situ cross-linking mass spectrometry and structural modeling to reveal compartmen...

In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility - Nature Communications Current mass spectrometry techniques for reading information stored in polymers require one sequencing experiment per sub-sequence, making the process slow. Here, the authors accelerate the reading pr...

Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation - Nature Communications Jin et al. discovered Atlantic grey seal milk contains 332 complex sugars, including 166 novel structures. Seal milk rivals human milk complexity, includes giant molecules up to 28 sugar units, change...

Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation #NatCommun #MassSpec www.nature.com/articles/s41...

2 0 0 1

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas - Nature Communications Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating s...

Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas #NatCommun #MassSpec www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Benchmarking informatics workflows for data-independent acquisition single-cell proteomics - Nature Communications Single-cell proteomics by data-independent acquisition (DIA) mass spectrometry is growing, but data analysis approaches vary widely. Here, authors benchmark and recommend optimal strategies for analyz...

Benchmarking informatics workflows for data-independent acquisition single-cell proteomics #NatCommun www.nature.com/articles/s41...

1 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

A mass spectrometry-based strategy allows signature metabolite identification in tear fluid from people with diabetic cataracts - Nature Communications Here, the authors develop an integrated mass spectrometry-based strategy that allows metabolic biomarker discovery based on nanoliter-scale biofluids in seconds. Biomarkers of diabetic cataracts are d...

A mass spectrometry-based strategy allows signature metabolite identification in tear fluid from people with diabetic cataracts #NatCommun www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

4 months ago

Breaking barriers in crosslinking mass spectrometry with enhanced throughput and sensitivity using Orbitrap Astral - Nature Communications Mapping protein interactions requires sensitive mass spectrometry. Here, the authors show that the Orbitrap Astral, combined with optimized chromatography, improves detection of low-abundance crosslin...

Breaking barriers in crosslinking mass spectrometry with enhanced throughput and sensitivity using Orbitrap Astral #NatCommun www.nature.com/articles/s41...

0 0 0 0

Kelly Chibale

@kellychibale.bsky.social

4 months ago

Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa - Nature Communications Authors analyzed malaria and tuberculosis drugs to create a pharmacometric model. They used an AI pipeline that prioritized pharmacogenetic drug-gene pairs with an emphasis on high variant frequency g...

(1/5) Our latest collaborative research project between @H3DCentre and @ersilia.io has recently been published in #NatCommun! Africa’s immense genetic diversity makes optimising drug treatments complex; this gap leads to limited pharmacogenetic data and suboptimal therapies for African populations.

0 1 1 0

BioMassSpec

@realbiomassspec.bsky.social

4 months ago

Protein-level batch-effect correction enhances robustness in MS-based proteomics - Nature Communications Batch effects in MS-based proteomics pose important challenges in protein quantification, and the optimal stage for batch-effect correction remains elusive and crucial. Here, the authors, through benc...

Protein-level batch-effect correction enhances robustness in MS-based proteomics #NatCommun www.nature.com/articles/s41...

1 0 0 0

Drug Discovery and Development Centre

@h3dcentre.bsky.social

4 months ago

Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa - Nature Communications Authors analyzed malaria and tuberculosis drugs to create a pharmacometric model. They used an AI pipeline that prioritized pharmacogenetic drug-gene pairs with an emphasis on high variant frequency g...

Africa's genetic diversity challenges effective drug treatments 💊 In #NatCommun, Turon and Mulubwa et al. present an AI-driven pipeline coupled to pharmacometrics to identify key drug-gene pairs and optimise doses for African populations, focusing on malaria and TB: www.nature.com/articles/s41...

0 0 0 0

BioMassSpec

@realbiomassspec.bsky.social

5 months ago

Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation - Nature Communications Young and colleagues describe an atmospheric pressure transmission-geometry MALDI approach equipped with plasma ionisation, which allows for subcellular mass spectrometry imaging of lipids and nucleot...

Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation #NatCommun www.nature.com/articles/s41...

0 0 0 0

Posts tagged #NatCommun