The answer is: Necrotizing Myopathy
To learn more, head to our blog: www.arkanalabs.com/needle-core-...
#neuropath #neuromuscular #neuronotes #pathology
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#NeuroNotes
Latest posts tagged with #NeuroNotes on Bluesky
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We have launched four neuropathology quizzes on our website! If you're interested in testing your neuropathology wisdom, head to our site. #neuropathology #neuromuscular #pathology #neuropath #neuronotes
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1/ What is the best pathologic diagnosis? Clinical history in thread.
#NeuroNotes #neuropath #pathology #neuromuscularpath
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The answer is: Denervation (neurogenic atrophy) and incidental vascular amyloid deposition
To learn more, head to our blog: www.arkanalabs.com/denervation-...
#neuropath #neuromuscular #neuronotes #pathology
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The answer is: Vacuolar myopathy due to hydroxychloroquine toxicity
To learn more, head to our blog: www.arkanalabs.com/toxic-vacuol...
#neuropath #neuromuscular #neuronotes #pathology
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1/ This 50-year-old patient presented with a one yearhistory of of persistent muscle weakness. They also had shortness of breath with exertion.
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The answer is: D.) Duchenne muscular dystrophy
To learn more, head to our blog: www.arkanalabs.com/sporadic-lat...
#neuropath #neuromuscular #neuronotes #pathology
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(1/2) The patient is a 69-year-old male who presented with complaints of proximal lower extremity muscle weakness and BMI of 37. His home medication list includes atorvastatin. Bilateral thigh biopsies were performed to evaluate for myopathy.
#NeuroNotes #neuropath #pathology #neuromuscularpath
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The answer is: Collagen pockets
To learn more, head to our blog: www.arkanalabs.com/collagen-poc...
#neuropath #neuromuscular #neuronotes #pathology
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(1/3) This 40-year-old patient underwent sural nerve biopsy to evaluate for a painful mixed large fiber and small fiber axonal neuropathy. The biopsy showed light microscopic features of a chronic active axonopathic process.
#NeuroNotes #neuropath #pathology #neuromuscularpath
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The answer is: The terminal boutons of the motor axons are missing from the neuromuscular junction (NMJ).
To learn more, head to our blog: www.arkanalabs.com/denervated-n...
#neuropath #neuromuscular #neuronotes #pathology
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(1/2) Muscle biopsy from this 40-year-old patient showed morphologic and enzyme histochemical features of denervation.
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
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The answer is: C.) PCR fragment analysis of DPMK
To learn more, head to our blog: www.arkanalabs.com/ring-fibers/
#neuropath #neuromuscular #neuronotes #pathology #pathX
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Answer choices:
A.) PCR fragment analysis of CNBP
B.) Muscular dystrophy gene panel
C.) PCR fragment analysis of DPMK
D.) Myositis specific antibody panel
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
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Which genetic test is required to establish the diagnosis in this 59-year-old with distal muscle weakness, mild myotonia, and persistently elevated CPK values (200-300 U/L)?
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
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The answer is: Denervation, reinnervation, and myofibrillar myopathy
To learn more, head to our blog: www.arkanalabs.com/vacuolar-myo...
#neuropath #neuromuscular #neuronotes #pathology #pathX
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The patient is a 92-year-old-male and presented progressive muscle weakness that began in the left upper extremity and spread to the BLEs and bulbar muscles. CK WNL. EMG/NCS: widespread denervation and reinnervation.
Based on the images below what is the most likely etiology? #NeuroNotes #pathsky
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The answer is hybrid myofibers.
To learn more, head to our blog: www.arkanalabs.com/hybrid-myofi...
#neuropath #neuromuscular #neuronotes #pathology #pathsky
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This previously healthy 35-year-old patient presented with proximal upper and lower extremity weakness and myalgias. Laboratory studies showed normal CPK. The patient's home medication is negative for myotoxic medications.
#NeuroNotes #neuropath #pathology #neuromuscularpath
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Correct Answer: Amyloidosis
Head to our blog for a more detailed explanation and additional reading: www.arkanalabs.com/76-year-old-...
#neuropath #neuromuscular #neuronotes #pathology
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(1/3) The patient is a 76-year-old man with numerous complaints including weakness, myalgia, arthralgia, back pain radiating down bilateral legs, cramps and twitching, imbalance, speech disorder, difficulty walking, and numbness.
#NeuroNotes #neuropath #pathology #neuromuscularpath
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Diagnosis: Neuromuscular junction (aka motor end-plate)
Head to our blog for a more detailed explanation and additional reading: www.arkanalabs.com/neuromuscula...
#neuropath #neuromuscular #neuronotes #pathology #pathX
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Muscle bx was performed on 60 y/o patient w/ complaints of muscle weakness. Several small intramuscular nerve twigs were noted on glutaraldehyde-fixed toluidine blue stained thick sections.
What normal structure is demonstrated in the electron microscopy images?
#NeuroNotes #neuropath #pathology
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This 75-year-old patient presented with slowly progressive generalized muscle weakness of approximately 2 years’ duration.
What is your diagnosis based images from figures #1 - #4?
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Teenage male with normal developmental milestones but difficult playing sports or running.
What is your diagnosis?
#NeuroNotes #neuropath #pathology #neuromuscularpath
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2/ Brain MRI was normal. A biopsy was performed.
What is your diagnosis based on H&E, immunohistochemical (EMA, GFAP and KI67) and MYCN FISH images?
#neuromuscularpath #neuropath #neuronotes
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1/ This 50-year old patient presented complaints of upper and lower extremity proximal and distal muscle weakness. They also related recent painful skin lesions.
#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
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1/ This 45-year-old patient underwent muscle biopsy to evaluate for muscle weakness. The biopsy showed denervation type changes (neurogenic atrophy). An unusual looking muscle fiber was noted on paraffin sections.
#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
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Head to our blog to read the answer to this week's #NeuroNotes: www.arkanalabs.com/partially-ne...
#neuropath #neuromuscular #pathology
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1/ The 21-year-old patient presented with skin rash and proximal upper and lower extremity weakness of several weeks duration. Laboratory studies showed elevated CPK (12000 to 14000 range).
#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
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