#OrgChem

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 hours ago

Cell-penetrating peptides for therapeutic applications: emerging design strategies and future directions Cell-penetrating peptides (CPPs) are short amino acid sequences capable of traversing biological membranes and enabling intracellular delivery of diverse therapeutic cargos, thereby addressing core…

Don't miss in our latest issue this review dissecting the physicochemical design principles governing cell-penetrating peptide membrane interactions by Jiyoun Lee & co. at Sungshin Women's University #orgchem #medchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

23 hours ago

A supramolecular host with a cavitand core and four cholate side arms Copper(i)-catalyzed azide–alkyne cycloaddition (CuAAC) was employed to synthesize a new cavitand (1) having four cholate groups covalently connected to the cavitand core. CuAAC between a…

🔓Check out a #OpenAccess paper by Beijun Cheng, Angel E. Kaifer & co. @univmiami.bsky.social & Qilu University of Technology in our latest issue describing a supramolecular host with a cavitand core and four cholate side arms #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 days ago

Regioselective House–Meinwald rearrangement in oxindoles: access to substituted quinolinones House–Meinwald rearrangement of oxindole substrates facilitating a one-pot synthesis of 3-substituted 4-hydroxyquinolin-2-ones and quinoline-2,4-diones under EBHP and base-mediated conditions is…

Take a look in our latest issue at research from Sasidhar B. Somappa et al. reporting regioselective House–Meinwald rearrangement in oxindoles for access to substituted quinolinones #orgchem

📍CSIR-NIIST

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 days ago

Forcing the phenyl moiety into the axial position by embedding the 2-phenyl-1,3-dioxane system in a tricyclic benzomorphan scaffold: design, synthesis and biological evaluation The relative configuration and the substitution pattern control the interaction of 2-(2-phenyl1,3-dioxan-4-yl)ethan-1-amines with σ1 receptors or the PCP binding site of NMDA receptors. In order to…

🔓Be sure to read a #OpenAccess paper by Bernhard Wünsch & co. @uni-muenster.de in our latest issue embedding the 2-phenyl-1,3-dioxane system in a tricyclic benzomorphan scaffold to fix the phenyl moiety into the axial position #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 days ago

The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds The Ugi–Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic…

Don't miss this review in our latest issue by Teodoro Kaufman et al. from Universidad Nacional de Rosario looking at recent developments and mechanistic insights of the Ugi–Joullié three-component reaction #orgchem #natprod

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

4 days ago

📢Our latest issue is now online!

Check out the paper behind the cover from Guidong Lu, Minshou Wang, Shizhi Jiang & co. at Dali University describing the synthesis of a series of novel meroterpenoid natural products #orgchem #natprod

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

6 days ago

DNA-based cooperative games: an interactive collective decision-making architecture Game theory provides an architecture for multi-agent strategic interactions, while DNA computing offers programmable, parallel molecular-scale operations, enabling unique “molecular gaming” systems…

Be sure to read research by Qiang Zhang & co. from Dalian University of Technology in our latest issue reporting a programmable majority-rule game-theoretic DNA based platform for molecular systems #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

Sustainable and green approaches for Knoevenagel condensation The Knoevenagel condensation reaction is one of the important and versatile transformations used to prepare a wide range of organic compounds bearing carbon–carbon double bonds. Therefore, it has…

Don't miss this review in our latest issue from Vinod Kumar et al. at Central University of Haryana summarising the recent developments in greener and sustainable synthetic approaches for Knoevenagel condensation #orgchem #greenchemistry

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

TropMol: a cloud-based web tool for virtual screening and early-stage prediction of acetylcholinesterase inhibitors using machine learning Alzheimer's disease (AD) is the most common type of dementia, accounting for at least two-thirds of dementia cases in people aged 65 and older. Numerous approaches have been studied for the treatment…

Check out this paper by Thiago H. Doring at the Federal University of Santa Catarina describing a new cloud-based web tool for virtual screening and early-stage prediction of acetylcholinesterase inhibitors using machine learning #compchem #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

Take a look in our latest issue at a paper by Ahmad Takallou, Ahmed Al-Harrasi & co. describing how intramolecular hydrogen bonding in phenolic amides enables direct synthesis of indolizines #orgchem

📍University of Nizwa

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

Be sure to read research from Lin Dong et al. at Sichuan University in our latest issue reporting the synthesis and biological evaluation of fluorinated bergenin derivatives #orgchem

Find their full report on our website👇

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

🔓Don't miss this #OpenAccess review, part of our New Talent collection, in our latest issue by @syruegas.bsky.social & co. @yruegasgroup.bsky.social discussing recent advances of well-defined alkali metal complexes in organic synthesis #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 week ago

📢Our latest issue is now online!

Check out the paper behind the cover by Mattie Timmer, Bridget Stocker & co. @vicuniwgtn.bsky.social reporting the design & assessment of dimeric trehalose glycolipids to enhance Mincle-mediated vaccine adjuvanticity #medchem #orgchem

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The Hartwig Group

@hartwiggroup.bsky.social

1 week ago

Our postdoc Willi Amberg built SynStrategy, a learning tool that categorizes 500+ reactions by functional group with 400+ total synthesis examples. If you’re into #OrgChem, check it out (it’s free)!

iOS:  apps.apple.com/de/app/synst...
Android: play.google.com/store/apps/d...

#ChemSky

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

Controlled packing of metal–peptide superhelices with β-peptide foldamers Metal–peptide superhelices formed from 12/10-helical β-peptide foldamers exhibit programmable hierarchical assembly. A single metal-coordinated superhelix organizes into distinct parallel or…

🔓Don't miss #OpenAccess research by Soo Hyuk Choi et al. from Yonsei University on the controlled packing of metal–peptide superhelices with β-peptide foldamers #orgchem #supramolecular

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

Unusual C-2 selectivity of Grignard additions to N-Boc-protected isatin 3-imines A series of N-tert-butoxycarbonyl-protected isatin 3-imines underwent an unexpected C-2 selective addition reaction with Grignard reagents, affording 3-imino-2-phenethylindolin-2-ols. The protecting…

🔓Check out this #OpenAccess paper from Amanda Louise Rousseau & co. at the University of the Witwatersrand showcasing unusual C-2 selectivity of Grignard additions to N-Boc-protected isatin 3-imines #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

Recent advances in electrosynthesis of 2-oxazolines 2-Oxazolines are important N- and O-containing five-membered heterocyclic compounds. Compared to traditional methods for synthesizing 2-oxazolines, organic electrochemistry, which utilizes electrons…

Take a look at this review in our latest issue by Yong Yuan & co. highlighting the most recent developments in the electrosynthesis of 2-oxazolines #orgchem #electrochem

📍Northwest Normal University

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

🔓Be sure to read a #OpenAccess paper by André M. Beauchemin et al. at @uottawa.ca in our latest issue describing a hydroxylamine alkylation/catalytic reduction sequence for tertiary amine synthesis #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

Chemoselective enzymatic acylation of glycine as a green route to N-acyl amino acid surfactants N-Acyl amino acids are very important industrial surfactants, being gentle on the skin and completely biodegradable. The synthetic routes described in the literature involve the use of highly reactive...

🔓Don't miss this #OpenAccess paper in our latest issue by Luca Banfi & co. from the University of Genova reporting the chemoselective enzymatic acylation of glycine as a green route to N-acyl amino acid surfactants #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

📢Our latest issue is now online!

Check out the research behind the cover by Saugata Hazra & co. from IIT Roorkee targeting class A carbapenemases with monocyclic and bicyclic boronic acids to counter antimicrobial resistance #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

🎉We are delighted to announce that Professor Shigeki Matsunaga (Kyoto University) has joined the OBC Editorial Board as an Associate Editor! #chemsky #orgchem

Learn more about Shigeki here🔽
blogs.rsc.org/ob/2026/02/2...

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

2 weeks ago

Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines Herein, we report a new methodology for the electrochemical oxidative C–H trifluoromethylation of 4-phenylthiazol-2-amines in an undivided cell using a glassy carbon electrode (GCE) and sodium…

Be sure to read in our latest issue research from Ramazan Koçak, Fatma Bayrakçeken Nişancı, Bilal Nişancı & co. at Ataturk University on the electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

Directing chiral induction in hollow helical organic nanotubes Helical aromatic oligoamides were synthesized via a polymerization strategy from amino acid-derived monomers to probe side-chain steric effects on helical chirality. Circular dichroism revealed…

🔓Don't miss this paper, part of our Foldamers collection, by @kilbinger-group.bsky.social & co. @unifrchemistry.bsky.social in our latest issue reporting how to direct chiral induction in hollow helical organic nanotubes #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

Multigram-scale synthesis of an experimental antibiotic, Lolamicin and its intermediate Herein, we report a multigram-scale synthesis of the recently discovered antibiotic Lolamicin. To enable rapid analogue generation for lead optimisation, a key intermediate bearing three sites of…

Check out research by D. Srinivasa Reddy & co. from CSIR-IICT in our latest issue describing the multigram-scale synthesis of an experimental antibiotic, Lolamicin and its intermediate #orgchem #medchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

Recent advances in the synthesis of organogermanium compounds using Ge–H as a radical precursor Organogermanium compounds are widely used in organic synthesis, medicinal chemistry, and materials science, attracting significant attention from organic chemists. As a result, the development of…

Take a look in our latest issue at this review from Rong-Nan Yi, Wei-Min He et al. summarising the recent advances in the synthesis of organogermanium compounds using Ge–H as a radical precursor #orgchem

📍University of South China

Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions The replacement of N,N-dimethylformamide (DMF) in solid-phase peptide synthesis (SPPS) is critical for improving the sustainability and safety of peptide research. While N-butyl-2-pyrrolidinone (NBP)…

🔓Be sure to read this #OpenAccess paper by @science-chat.bsky.social & co. @uofgchem.bsky.social in our latest issue expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

Base-promoted decarboxylative condensation of cinnamonitriles and phenylacetic acids with sulfur: direct access to azatrithiapentalenes We report herein a one-step three-component decarboxylative strategy for the construction of novel azatrithiapentalenes from readily available cinnamonitriles, arylacetic acids and elemental sulfur.…

Don't miss this research in our latest issue by Dinh Hung Mac, Quoc Anh Ngo, Thanh Binh Nguyen et al. from @univparissaclay.bsky.social reporting base-promoted decarboxylative condensation of cinnamonitriles & phenylacetic acids with sulfur #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

3 weeks ago

📢Our latest issue is now online!

Check out the paper behind the cover by Teodoro S. Kaufman & co. from Universidad Nacional de Rosario synthesising & evaluating analogs of tetracyclic Ganoderma alkaloids as inhibitors of the enzyme α-glucosidase #medchem #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 month ago

Optically active dihydro-1,4-benzoxazines: synthetic, separation, and enzymatic approaches Benzoxazine-based compounds, a class of heterocycles with diverse biological properties, hold strong potential in therapeutic areas such as anti-inflammatory, anti-cancer, anti-tuberculosis and…

Don't miss this review from Axelle Arrault, Samir Acherar & co. at @univlorraine.bsky.social in our latest issue covering the enantioselective synthetic strategies for optically active dihydro-1,4-benzoxazines #orgchem

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Organic & Biomolecular Chemistry

@orgbiomolchem.rsc.org

1 month ago

A hexadentate Co(III) catalyst enables one-pot quinazolinone synthesis via metal–ligand cooperative alcohol activation Herein, we present the first Co(iii)-catalysed efficient metal–ligand cooperative route for the synthesis of quinazolinones via dehydrogenation of primary alcohols. An air-stable phosphine-free…

Check out research in our latest issue by Kaushik Ghosh & co. from IIT Roorkee describing how a hexadentate Co(iii) catalyst enables one-pot quinazolinone synthesis via metal–ligand cooperative alcohol activation #orgchem

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