Arcane can sense souls, so he can hold his own in a fight, but still has to navigate around physical obstacles as a blind person would.
The Hood has dissociative identity disorder, and the trigger for his alter (who has enhanced hearing and smell) taking control is being blinded. If he ever became totally blind, he would simply be the Hood full-time.
InvisiBelle is blind when using her powers, so she could eventually adapt to full blindness.
DJ “sees” by sensing radio waves. They don’t have eyes or normal vision.
As for the sighted:
The Word would probably have the second hardest time. His power requires him to write, and his combat training is no help if he can’t see.
Black Dahlia would have it rough, but she has a pretty big support network (her family), plus a sighted ghost grandfather who is always by her side, so she does okay.
Moonlighter has trained to fight while blinded and navigate using his other senses alone. Get him in a workshop and he’ll probably start building some kind of artificial replacement for his eyesight.
Sameko has very good smell and can sense electrical currents (including those in the human body). She does just fine without sight.
Plain Jane would have a much harder time than the Word, because she’s already suffering from a power that obscures her presence from other people. If she has to rely on other people to help her navigate, she’s screwed.
Mr. Q has had similar training to Moonlighter, and as an added bonus, a side effect of his power is he can tell when anyone is able to see him.
#Paragons has a few characters who are already blind.