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Did you know that you can Partner with KBtL for just $5. And while you support us, we also support you with Mutual Aid Advertising. Apply today with the link in bio.

#mutualaid #virtualkink #support #partnerships #partnering #bdsm #kinkeducation

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All set for an exciting day at Biocapital Europe in Amsterdam #Inverna #BioCapital2026 #Biotech #RNA #SpliceModulation #Neurodegeneration #ParkinsonsDisease #HuntingtonsDisease #PrecisionMedicine #BiotechInvesting #Partnering

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MHA's Annual Meeting - Massachusetts Health & Hospital Association Agenda Welcome Anne Klibanski, M.D., President & CEO, Mass General Brigham, MHA Board Chair Fireside Chat: From Capitol Hill to the Commonwealth: Challenges, Progress, and Opportunity Morning Keynote ...

Join us at MHA’s Annual Meeting to help carry on the legacy of collaborative problem-solving, bold #innovation, and #partnering for #patients.

Secure your spot today for #Massachusetts healthcare’s signature conference ⤵️

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#Arm and #Nvidia are #partnering to integrate Arm-based #Neoverse #CPUs with Nvidia’s #GPUs using Nvidia’s #NVLink Fusion technology. This #collaboration will benefit customers, particularly #hyperscalers, who prefer custom infrastructure setups. The partnership highlights Nvidia’s strategy of…

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Hepatitis B Virus (HBV) continues to pose a significant global health challenge, with over 254 million chronic infections and current therapies being non-curative, necessitating lifelong treatment. The HBV ribonuclease H (RNase H) is essential during HBV reverse transcription by cleaving the viral pregenomic RNA after it has been copied into the (−) polarity DNA strand, enabling the viral polymerase to synthesize the (+) DNA strand. Although RNase H inhibition terminates viral replication and thus viral infectiveness, its targeting as an HBV treatment is unexploited. Its catalytic site contains four carboxylates that bind to two Mg2+ ions essential for RNA hydrolysis. As part of our ongoing research on RNase H inhibitors, we developed 23 novel N-hydroxypyridinedione (HPD) analogues. Specifically, 17 HPD imines, 4 HPD oximes, 1 2,6-diamino-4-((substituted)oxy)pyrimidine 1-oxide derivative, and 1 barbituric acid analogue were designed, synthesized, and tested for their anti-HBV activity. The HPD derivatives could be docked in the RNase H active site to coordinate the two Mg2+ ions and effectively inhibited viral replication in cellular assays. The 50% effective concentration (EC50) values of these HPD compounds ranged from 0.5 to 73 μM, while the 50% cytotoxic concentration (CC50) values ranged from 15 to 100 μM, resulting in selectivity indexes (SIs) up to 112. Furthermore, the novel HPD derivatives exhibited favourable pharmacokinetic-relevant characteristics, including high cellular permeability, good aqueous solubility, and overall drug-like properties. These findings indicate that HPD imines and oximes possess substantial antiviral potency and selectivity against HBV, underscoring the potential of the HPD scaffold as a promising framework for the development of next-generation anti-HBV agents.

Hepatitis B Virus (HBV) continues to pose a significant global health challenge, with over 254 million chronic infections and current therapies being non-curative, necessitating lifelong treatment. The HBV ribonuclease H (RNase H) is essential during HBV reverse transcription by cleaving the viral pregenomic RNA after it has been copied into the (−) polarity DNA strand, enabling the viral polymerase to synthesize the (+) DNA strand. Although RNase H inhibition terminates viral replication and thus viral infectiveness, its targeting as an HBV treatment is unexploited. Its catalytic site contains four carboxylates that bind to two Mg2+ ions essential for RNA hydrolysis. As part of our ongoing research on RNase H inhibitors, we developed 23 novel N-hydroxypyridinedione (HPD) analogues. Specifically, 17 HPD imines, 4 HPD oximes, 1 2,6-diamino-4-((substituted)oxy)pyrimidine 1-oxide derivative, and 1 barbituric acid analogue were designed, synthesized, and tested for their anti-HBV activity. The HPD derivatives could be docked in the RNase H active site to coordinate the two Mg2+ ions and effectively inhibited viral replication in cellular assays. The 50% effective concentration (EC50) values of these HPD compounds ranged from 0.5 to 73 μM, while the 50% cytotoxic concentration (CC50) values ranged from 15 to 100 μM, resulting in selectivity indexes (SIs) up to 112. Furthermore, the novel HPD derivatives exhibited favourable pharmacokinetic-relevant characteristics, including high cellular permeability, good aqueous solubility, and overall drug-like properties. These findings indicate that HPD imines and oximes possess substantial antiviral potency and selectivity against HBV, underscoring the potential of the HPD scaffold as a promising framework for the development of next-generation anti-HBV agents.

Novel hydroxypyridinedione (HPD) molecules have strong potential for development into new anti- Hepatitis B drugs. @slu-official.bsky.social John Tavis, NKUA (University of Athens) Grigoris Zoidis & colleagues share SAR and discuss in vitro ADMEPK doi.org/10.3390/ijms...
#Partnering #drugdevelopment

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AI that’s secure, governed and agile; GBM looks to redefine client partnering How best to empower talent and foster innovation in a fast-evolving landscape pre-occupied with AI-driven transformat...

#Features #Insight #Interviews #AI #Client #Partnering […]

[Original post on tahawultech.com]

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#Teachersunions are #partnering with #tech companies like #Microsoft, #OpenAI, and #Anthropic to #trainteachers on #AI. The goal is to help teachers stay relevant and prepare students for the future workforce. The partnerships involve millions in funding for #AItraining, with educators designing…

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Adsp Mtcs, nominati componenti organismo di partenariato della risorsa mare (Adnkronos) - Al fine di portare a completamento l’assetto istituzionale dell’AdSP oggi, con Decreto n° 208/2025, il Commissario Straordinario Raffaele Latrofa ha nominato i componenti dell’Organismo di partenariato della risorsa...

Adsp Mtcs, nominati componenti organismo di partenariato della risorsa mare ... LEGGI TUTTO #AdSP #risorsamare #nominati #partnering #istituzionale

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Ed Saltzman will be speaking at BioXconomy Digital Week taking place September 30– October 2, 2025, and the best part? It’s completely free to attend! Register here to secure your spot: buff.ly/zLaiHW7

#WebinarSeries #BioXconomy #LSX #Biopharma #Partnering #Investment

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Go Magic2.0 Business Pitch with Vadim Efimenko!

We're actively looking for business partners and angel investors to help us build the dream platform for every Go player.
https://youtu.be/Kf91G4zjLXM

Your shares help us reach the right people.Thank you!

#Pitch #Investing #Partnering #GoGame

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Spaces are filling quickly for our October Partnering with Business course. Secure your place today!

www.eventbrite.co.uk/e/partnering...

#partnering #professionaldevelopment

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If you're building something in #neurodegeneration, let's build it together, with patient-derived platforms that bring you closer to clinical relevance.

Let’s make a difference together ➡️ https://www.synapticure.com/for-partners/research


#partnering #biotech #drugdiscovery

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• Always love dancing Salsa and Tango with @yana.netreba 💎.

• Thanks @lizwattsandco for the opportunity.

#dancers #antoniomartinez #yananetreba #dancerlife #entertainment #dance #partnering #salsadancers #tangodancers

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Political uncertainties, tariffs, funding crunch? LSX World Congress upbeat despite the times The weather was hot in London for this year’s LSX World Congress – but what was the atmosphere like at Europe’s leading partnering, strategy, and investment event?

The weather was hot in London for this year’s #LSXWorldCongress – but what was the atmosphere like at Europe’s leading #partnering, #strategy, and #investment event? #biopharma

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We’re excited to share that NanoNewron will be at BIO 2025 in Boston!

Our CEO, Dr. Marco Taglietti, will be attending and looks forward to connecting with fellow biotech leaders, potential partners, and investors.

#BIO2025 #Biotech #LifeSciences #Innovation #Partnering

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Skyblivion project lead and GOG chat about partnering up to release the massive Elder Scrolls mod...


#Gaming #chat #elder #fallout #GOG #lead #Londons #massive #mod #partnering #project
Origin | Interest | Match

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Opening & closing act for @LagunaDanceFestival ✨ Loved dancing Salsa & Tango for this beautiful event!

• Performers: @antoniomartinezla & @Yan.netreba

• Rep: @B4brandon
@msaagency

#dancers #antoniomartinez #yananetreba #dancerlife #entertainment #dance #partnering #salsadancers #tangodancers

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Christian Groendahl and @evdh.bsky.social will be attending next week's #BioEquity in Bruges🇧🇪.

Reach out to learn more about our recent progress and updates of our pipeline.
#partnering #BioEquityEurope

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⏳ ONE week to GO — Ready to CONNECT at #ConnectionDay2025? 🚀
Creatio is excited to join this flagship networking event organized by #Catalonia.Health.

➡️ See you all there!

#Creatio #UniBarcelona #HealthInnovation #Partnering #B2B #ATMPs #AdvancedTherapies #TECNIO

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🚀 Connecting, collaborating, and creating opportunities!

The #partnering space is in full swing as #healthtech startups and investors come together.

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Getting to play Tarzan 💪🏽! 📸 Swipe ➡️ for 5 BTS pix of another unforgettable job 🫶🏽. Sharing more soon…

#Tarzan #Dancer #aerialist #Actors #dancers #Partnering #aerialists #dancerofinstagram #maledancer #AGT #AmericasGotTalent #aerialduo

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🌟 Delta4 is thrilled to be part of BIO-EUROPE SPRING in #Milan from March 17-18! Join CEO Kurt Herpel and CSO Klaus Kratochwill as they explore new partnering opportunities. Let’s connect in Italy's beautiful pharma capital!
delta4.ai/partnering

#bio-europe #partnering #informaconnect #AI #pharma

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#introduction Hi folks, I'm a #ServiceDesigner and #organiser in Naarm. I want to live in a fair and healthy world where we #co-design services with communities.

I work in #PublicHealth, #AccessToJustice or #A2J #DisabilityJustice

Geek out about methods, #partnering or wild side quests

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If YOU build an #IoT app enablement platform, WE want to talk to YOU about layering YOUR greatness on top OUR foundation #Azure #Partnering

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