#PhageScience

@physicscwru.bsky.social

1 week ago

4 days until the Freeman Lab-Warming Party! 🎉

Meet Angela Noreck, physics grad student and Freeman Lab researcher. She loves the supportive vibe and her favorite phage: Phrappuccino! ☕

Learn more: freemanbiophysics.org/scientists
#PhageScience Krista Freeman Freeman Lab of Bacteriophage Biophysics

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The Phage

@thephage.bsky.social

2 months ago

The Agar Overlay (Double-Layer Agar) Technique procedure

Today’s featured protocol: The Agar Overlay (Double-Layer Agar) Technique

A microbiology method for producing uniform bacterial lawns, widely used in phage research

thephage.xyz/protocol/aga...

#ThePhage #PhageScience #PhageResearch #LabProtocols #Microbiology #AcademicTwitter

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Shicheng Guo

@shihcheng.bsky.social

1 year ago

Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes | Nature Communications F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present the atomic structure of monocin, a genetically engineered F-type PTLB from Listeria monocytogenes. Our detailed atomic-level analysis, excluding two chaperone proteins, provides crucial insights into the molecular architecture of F-type PTLBs. The core structure of monocin resembles TP901-1-like phage tails, featuring three side fibers with receptor-binding domains that connect to the baseplate for host adhesion. Based on these findings, we propose a potential mechanism by which F-type PTLBs induce cell death, offering a foundation for developing targeted antibacterial therapies. F-type phage-tail like bacteriocins (PTLBs) are protein complexes with bactericidal activity and share similarity with non-contractile phage tails. Here, authors report the atomic st

Atomic structure of monocin from Listeria monocytogenes reveals key insights into F-type phage tail-like bacteriocins. Excludes 2 chaperones. #PhageScience PMID:39956822, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57075-3 #Medsky #pharmasky 🧪

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Posts tagged #PhageScience