#Podospora

@pierregrognet.bsky.social

8 months ago

Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina

Our description of the transcriptomic changes during sexual development in #Podospora anserina is out in @genomics.peercommunityin.org ! peercommunityjournal.org/articles/10....
@i2bcparissaclay.bsky.social @univparissaclay.bsky.social

4 6 0 0

S. Lorena Ament

@loreament.bsky.social

8 months ago

In the model fungus #Podospora anserina, the het-d
and het-e NLRs are highly polymorphic genes, whose products recognize different alleles of another gene, het-c. If two confronting strains have incompatible het-e/d and het-c alleles, a rejection reaction occurs. 3/n

0 0 1 0

S. Lorena Ament

@loreament.bsky.social

8 months ago

Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing NOD-like receptors (NLRs) are intracellular immune receptors that detect pathogen-associated cues and trigger defence mechanisms, including regulated cell death. In filamentous fungi, some NLRs mediat...

Happy to see this out! "Reconstructing NOD-like receptor alleles with high internal conservation in #Podospora anserina using long-read sequencing", now in ‪@microbiologysociety.org‬! 🧬

Keep reading for a simple explanation 🧵 1/n
#Fungi #Allorecognition
www.microbiologyresearch.org/content/jour...

9 3 2 1

Pierre Grognet

@pierregrognet.bsky.social

9 months ago

I am very proud to be part of this story!
Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina.

www.biorxiv.org/content/10.1...

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Ruhrpott-Pilze

@rpilze.masto.nu.ap.brid.gy

1 year ago

Podospora appendiculata on rabbit dung

#Podosporaappendiculata #Podospora #Dungfungi #Dungpilz #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends

1 0 0 0

Ruhrpott-Pilze

@ruhrpottpilze.bsky.social

1 year ago

Podospora appendiculata on rabbit dung

#Podosporaappendiculata #Podospora #Dungfungi #Dungpilz #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends

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Pierre Grognet

@pierregrognet.bsky.social

1 year ago

Genetic differentiation in the MAT-proximal region is not sufficient for suppressing recombination in Podospora anserina Abstract. Recombination is advantageous over the long-term, as it allows efficient selection and purging deleterious mutations. Nevertheless, recombination

Happy to share the last #Podospora paper!

With @tatianagiraud.bsky.social we show that the sequence polymorphisms around the mating-type are rather a consequence than the cause of recombination inhibition.

@univparissaclay.bsky.social @i2bcparissaclay.bsky.social @ideevl.bsky.social

7 6 0 0

Ruhrpott-Pilze

@rpilze.masto.nu.ap.brid.gy

1 year ago

Podospora australis

#Podosporaaustralis #Podospora #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends #dungfungiweek

2 0 0 0

Ruhrpott-Pilze

@ruhrpottpilze.bsky.social

1 year ago

Podospora australis

#Podosporaaustralis #Podospora #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends #dungfungiweek

8 0 0 0

Ruhrpott-Pilze

@rpilze.masto.nu.ap.brid.gy

1 year ago

Podospora australis

#Podosporaaustralis #Podospora #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends #Dungfungi

5 2 0 0

Ruhrpott-Pilze

@ruhrpottpilze.bsky.social

1 year ago

Podospora australis

#Podosporaaustralis #Podospora #mushroom #mushrooms #fungus #fungi #pilz #pilze #champignons #champignon #nature #natur #FungiFriends #Dungfungi

12 0 0 0

S. Lorena Ament

@loreament.bsky.social

1 year ago

Starship Discovery: A Collaborative Approach to Uncover Massive Transposable Elements The ability to generate high-quality fungal genomes brought with it new frontiers of scientific discovery and paved the way for answering outstanding biological mysteries. Recently, several independen...

We wrote a review in a slightly different, lighthearted style 😁.
"Starship Discovery: A Collaborative Approach to Uncover Massive Transposable Elements" 🚀🧬

Thank you and congratulations to the coauthors!
#fungi #genomics #transposons #science #Podospora

link.springer.com/chapter/10.1...

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Pierre Grognet

@pierregrognet.bsky.social

1 year ago

Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina Despite the inherent challenge of finding suitable mating partners, most eukaryotes use sexual reproduction to produce offspring endowed with increase genetic diversity and fitness. The persistence of...

And another preprint this week! 🍄🎉
This time it's about gene expression from fertilization to spores formation in our favorite fungus #Podospora anserina.

#parissaclay #i2bc

www.biorxiv.org/content/10.1...

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Pierre Grognet

@pierregrognet.bsky.social

1 year ago

Genetic differentiation in the MAT-proximal region is not sufficient for suppressing recombination in Podospora anserina Recombination is advantageous over the long-term, as it allows efficient selection and purging deleterious mutations. Nevertheless, recombination suppression has repeatedly evolved in sex chromosomes and mating-type chromosomes. The evolutionary causes for recombination suppression and the proximal mechanisms preventing crossing overs are still poorly understood. Several hypotheses have recently been suggested based on theoretical models, and in particular, that divergence could accumulate neutrally around a sex-determining region and reduce recombination rates, a self-reinforcing process that could foster progressive extension of recombination suppression. The ascomycete fungus Podospora anserina is an excellent model for investigating these questions. A 0.8 Mb region around the mating-type locus is non-recombining, despite being collinear between the two mating types. This fungus is mostly selfing, so that strains are highly homozygous, except in the non-recombining region around the mating-type locus that displays differentiation between mating types. Here, we generated a mutant to test the hypothesis that sequence divergence alone is responsible for recombination cessation. We replaced the mat- idiomorph by the sequence of the mat+ idiomorph, to obtain a strain that is sexually compatible with the mat-reference strain and isogenic to this strain in the MAT-proximal region. Crosses showed that recombination was still suppressed in the MAT-proximal region in the mutant strains, indicating that other proximal mechanisms than inversions or mere sequence divergence are responsible for recombination suppression in this fungus. This finding suggests that selective mechanisms likely acted for suppressing recombination, as the neutral model does not seem to hold, at least in this fungus. ### Competing Interest Statement The authors have declared no competing interest.

Happy to see our last preprint online! We show that a mysterious recombination inhibition persists even with identical sequences on both mating-type chromosomes in our favorite fungus #Podospora anserina.

www.biorxiv.org/content/10.1...

#universiteparissaclay #i2bc #ideev #cnrs