#RCT

JMIR Publications

@jmirpub.bsky.social

8 hours ago

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial Date Submitted: Feb 17, 2026. Open Peer Review Period: Mar 11, 2026 - May 6, 2026.

Reminder>> Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Moonlander

@lespops.bsky.social

1 day ago

A clear sunny day sits between two stormy fronts, and it’s impossible not to heed its call. #Publicrightofway #definitivemap #rct #pontypridd #nature #walking #routes #footpath

JMIR Publications

@jmirpub.bsky.social

1 day ago

Reminder>> A Fully Remote Serious #Game for Cognitive Control Training in Major Depressive Disorder: A #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Birch Twigs

@birchtwigs.bsky.social

1 day ago

WPGN is LIVE NOW!
Life is a RollerCoaster! Let's Tycoon! Checking out more of the DLC parks and having a cozy vibe. Find your seat in the theater at www.twitch.tv/birchtwigs

#WPGN #RCT #OpenRCT #RollerCoaster #Chill

Gordon H. Guyatt

@guyattgh.bsky.social

2 days ago

Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid - PubMed With the possible exception of blinding of data analysts, use of "probably yes" and "probably no" instead of "unclear" may enhance the assessment of blinding in trials.

Looking at an #RCT to decide who among #patients, #clinicians, data collectors, et al is #blinded and it’s not clear and explicit? Happens often. Fortunately, almost always enough clues that if you follow instructions in this paper you will make the right inference.
pubmed.ncbi.nlm.nih.gov/22200346/

JMIR Publications

@jmirpub.bsky.social

2 days ago

Reminder>> Immersive 3D Simulation vs. Physical Models in Training Novices for Laser-based Endourological Procedures - #Research #Protocol for a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

JMIR Publications

@jmirpub.bsky.social

3 days ago

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial Date Submitted: Feb 17, 2026. Open Peer Review Period: Mar 11, 2026 - May 6, 2026.

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

J-PAL North America

@j-palna.bsky.social

3 days ago

Real-Time Pricing to Reduce Electricity Use in the United States | The Abdul Latif Jameel Poverty Action Lab During periods of high electricity use that strain the grid, electricity customers do not have any reason to conserve because they pay a fixed price per kilowatt hour of power. In this study, the rese...

Periods of high electricity use⚡ strain the grid. One #RCT found that real-time pricing could be a promising strategy to conserve electricity and reduce strain: www.povertyactionlab.org/evaluation/real-time-pri...

JMIR Publications

@jmirpub.bsky.social

3 days ago

Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial Background: Nonspecific low back pain (NSLBP) is a significant global public health concern that affects the health and well-being of individuals across different age groups, limiting their daily activities and reducing their quality of life. As Tuina (Chinese therapeutic massage) therapy and medicated oil are widely used in China, it is necessary to design a randomized clinical trial to assess the effectiveness of Tuina combined medicated oil (TNO) in treating NSLBP. Objective: This #Study aims to evaluate the efficacy and safety of Tuina therapy combined with medicated oil in treating NSLBP. Methods: One hundred participants will be enrolled and randomly allocated to either a TNO group (n=50) or a Tuina combined water group (n=50). Treatment will last for 4 weeks, with sessions 3 times a week, followed by a 4-week follow-up. The visual analog scale score is the primary outcome; secondary outcomes include the evaluation of treatment Japanese Orthopaedic Association scores, infrared thermography, muscle tension tests, and tenderness scores. All adverse reactions will be recorded. Results: The trial commenced in June 2023 and is expected to conclude in September 2025. In June 2025, key preliminary steps were completed, and the ethical review and clinical trial registration were concluded. Recruitment is proceeding as planned, with 100 participants enrolled to date. Data collection is underway, while formal data analysis has not yet commenced. Conclusions: The project’s purpose is to evaluate the effectiveness of TNO in alleviating pain and improving lumbar function in patients with NSLBP. Trial Registration: ChiCTR ChiCTR2300076144; https://www.chictr.org.cn/hvshowproject.html?id=247247 International Registered Report Identifier (IRRID): DERR1-10.2196/81887

JMIR Res Protocols: Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial

Presse83.fr

@presse83.fr

3 days ago

RCT - Pierre Mignoni de retour au Campus RCT : quel impact pour le choc face au Stade Français ? Pierre Mignoni est de retour au Campus RCT après trois semaines d’absence pour raisons de santé.

Pierre Mignoni de retour au Campus RCT avant le choc face au Stade Français #RCT #PierreMignoni #Top14 presse83.fr/2026/03/11/p...

JMIR Publications

@jmirpub.bsky.social

4 days ago

A Fully Remote Serious #Game for Cognitive Control Training in Major Depressive Disorder: A #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

JMIR Publications

@jmirpub.bsky.social

4 days ago

Virtual Reality for the Management of #postoperative Pain and Anxiety in Children and Adolescents Undergoing Nuss Repair of Pectus Excavatum: #rct Background: Virtual reality (VR) is a novel technology with implications for pain and sensory processing. VR may serve as a novel, scalable method to deliver clinically validated therapy for pain management as an alternative or adjunct to opioids for acute pain. Given that psychological factors and pain perception are both components of #postoperative pain, it may also be beneficial to incorporate modalities that decrease anxiety, such as active relaxation and guided meditation with VR. Unfortunately, these therapies are not widely available due to multiple barriers. VR has the potential to deliver pain-reducing, psychologically based therapy to children, thereby enhancing multimodal analgesia and potentially decreasing opioid use. This #study investigates the role of VR in reducing pain and anxiety after #surgery. Given the substantial risks associated with opioid use, particularly in younger populations, alternative pain management strategies are crucial. Objective: The primary aim of this #study was to evaluate the efficacy of VR as a nonpharmacological intervention for managing #postoperative pain intensity, pain unpleasantness, anxiety, and opioid use in children and adolescents undergoing Nuss repair of pectus excavatum. Methods: A single-center, prospective, randomized, controlled trial was conducted at a tertiary care children’s hospital and research center. Ninety children and adolescents (8-18 y) undergoing the Nuss procedure were randomized to guided relaxation or mindfulness VR (n=30) and distraction-based gaming VR (n=30), combined to form the VR group (n=60), and a control group using a passive 360° video (n=30). #patients received a 10-minute session on #postoperative days 1 and 2. Pain intensity, pain unpleasantness, and anxiety were evaluated before and 0-, 15-, and 30-minute post-session. In-hospital pain scores, anxiety scores, and opioid use were collected. Results: Children and adolescents who participated in VR reported a significantly greater decrease in pain intensity from baseline (0.41, SE 0.23) compared with those in the 360° video group at 30 minutes (=.04) before multiplicity adjustment but not after multiplicity adjustment. There were no significant differences in pain scores or opioid use between the VR and control groups on #postoperative day 1 or 2, nor were there changes in pain unpleasantness or anxiety at any time after the intervention. Conclusions: Daily, 10-minute VR sessions provided some trends toward transient analgesic and anxiolytic effects, albeit none that were statistically significant. VR did not significantly decrease overall pain scores or opioid usage, possibly due to the limited intervention duration and high standardized opioid use. Future studies should investigate extended and more frequent VR sessions and the integration of VR with other therapeutic modalities. Trial Registration: ClinicalTrials.gov NCT04351776; https://clinicaltrials.gov/#study/NCT04351776

New JMIR Periop Med: Virtual Reality for the Management of #postoperative Pain and Anxiety in Children and Adolescents Undergoing Nuss Repair of Pectus Excavatum: #rct

Trials Change Lives

@trialschangelives.bsky.social

4 days ago

Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

JMIR Publications

@jmirpub.bsky.social

5 days ago

Immersive 3D Simulation vs. Physical Models in Training Novices for Laser-based Endourological Procedures - #Research #Protocol for a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

British Journal of Anaesthesia

@bjajournals.bsky.social

6 days ago

#EPITUBE: Does prophylactic #norepinephrine reduce post-induction severe hypotension in cardiac surgery? This #RCT by Gaillard et al. found no reduction in severe hypotension, #AKI, ventilatory duration, or ICU length of stay vs on-demand ephedrine.

bjanaesthesia.org/article/S0007-0912(25)00795-0/

JMIR Publications

@jmirpub.bsky.social

6 days ago

Reminder>> Effects of breathing exercises on #Pain, disability, range of motion and muscle endurance in #Patients with chronic low back #Pain, a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Kate Strasdin

@katestrasdin.bsky.social

6 days ago

A long sleeveless cream satin ballgown decorated with gold trelliswork and floral embroidery

A black and white photograph of women embroiderers from the 1940s working for Norman Hartnell. Two women are working at a frame in front of them beading a piece of silk

An embroidery sample showing a spray of flowers created by Hartnell’s embroiderers for the coronation gown of Queen Elizabeth II

Happy International Women’s Day! Acknowledging the hands of countless women in the needle trades through the lens of the women in Norman Hartnell’s embroidery workroom. Their legacy survives in the glittering gowns they embellished. Dress 1950s #RCT #FashionHistory 🗃️🪡

Gordon H. Guyatt

@guyattgh.bsky.social

1 week ago

Key study of Grail’s cancer detection test fails in setback for company Grail's blood test for detecting cancer early failed to meet its main goal in a giant study being conducted with England’s NHS, the company said.

Company, new #tests for early #CancerDetection to decrease late-stage #cancer and #mortality sold 185k in 2025 at $1k a crack. Problem: just completed #RCT no benefit either outcome. Latest evidence cancer screening limitations, need to wait for evidence of benefit.

www.statnews.com/2026/02/19/g...

JMIR Publications

@jmirpub.bsky.social

1 week ago

Reminder>> Acupuncture and related therapies for post-infectious cough: #Protocol for a systematic review and meta-analysis of #RCT #ClinicalTrials (preprint) #openscience #PeerReviewMe #PlanP

British Journal of Anaesthesia

@bjajournals.bsky.social

1 week ago

New #RCT showing a prophylactic infusion of #noradrenaline was not superior to rescue #ephedrine at preventing severe hypotension in #cardiacsurgery

www.bjanaesthesia.org/article/S0007-0912(25)00...

JMIR Publications

@jmirpub.bsky.social

1 week ago

Integrative Traditional East Asian #Medicine-Based Adjunctive Therapies for Prostate #Cancer #Patients Undergoing Standard #Cancer Treatment: #Protocol for a Systematic Review and Meta-Analysis of #RCT #ClinicalTrials Date Submitted: Feb 25, 2026. Open Peer Review Period: Mar 3, 2026 - Apr 28, 2026.

Reminder>> Integrative Traditional East Asian #Medicine-Based Adjunctive Therapies for Prostate #Cancer #Patients Undergoing Standard #Cancer Treatment: #Protocol for a Systematic Review and Meta-Analysis of #RCT #ClinicalTrials (preprint) #openscience #PeerReviewMe #PlanP

JMIR Publications

@jmirpub.bsky.social

1 week ago

Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease Who Experience Mental Health Symptoms: #Protocol for the POPMIX-MH Cluster #RCT #ClinicalTrial Background: Chronic obstructive pulmonary disease (COPD) and mental health conditions represent intersecting public health challenges, especially in resource-limited rural China. Existing care models often neglect the psychosocial needs of populations at high risk for COPD, resulting in limited effectiveness of prevention and management strategies. This #Study evaluates an integrated intervention designed to improve both mental and physical health outcomes among high-COPD-risk individuals with mental health symptoms, using a population medicine framework. Objective: This #Study aims to evaluate the effect of an integrated, population medicine–based multimorbidity intervention package among high-COPD-risk individuals with mental health symptoms in Xishui County, Guizhou Province, China. Methods: We are conducting a 12-month, 2-arm cluster #RCT #ClinicalTrial across 26 townships in Xishui County, Guizhou, China. A total of 44,000 residents aged ≥35 years were screened using the Chronic Obstructive Pulmonary Disease Screening Questionnaire, identifying 10,000 individuals at high risk of COPD. Among them, 3807 individuals with Warwick-Edinburgh Mental Well-Being Scale scores below 45 were enrolled as participants. Intervention components include #Digital cognitive behavioral therapy–based mental health support, community screening, chronic disease management, patient education, #Digital follow-up, and team-based care. The primary outcomes are depressive symptoms (9-item Patient Health Questionnaire), anxiety symptoms (7-item General Anxiety Disorder), and mental well-being (Warwick-Edinburgh Mental Well-Being Scale). Secondary outcomes are control of chronic diseases, physiological and functional indicators such as lung function, health-related quality of life, mental and behavioral health, health care utilization, knowledge of COPD and asthma, productivity loss, and care cascade indicators for chronic conditions. Results: Data collection for the POPMIX-MH trial began in June 2024. Baseline, 3-month, and 6-month assessments have been completed, and the 12-month follow-up assessments are planned to be completed in March 2026. Conclusions: This #Study is the first to integrate psychological support, chronic disease management, and community-based screening into a single scalable intervention package targeting multimorbidity in China. It tests the feasibility of applying population medicine principles, emphasizing integrated, preventive, and population-level care, within primary care systems in low-resource settings. By targeting both mental and physical health, it redefines chronic care beyond traditional organ-specific approaches. Trial Registration: ClinicalTrials.gov NCT06458218; https://clinicaltrials.gov/ct2/show/NCT06458218

JMIR Res Protocols: Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease Who Experience Mental Health Symptoms: #Protocol for the POPMIX-MH Cluster #RCT #ClinicalTrial

Moonlander

@lespops.bsky.social

1 week ago

If there is a time of year to attempt discovery of a difficult or hidden pathway – it is now – when the winter branches are at their barest, and the spring is still too new too have powered up the thick growth of bracken and brambles that render unkept pathways invisible. #pathways #rct #pontypridd

MHM Wales

@mhmwales.bsky.social

1 week ago

What should we prioritise next at Calfaria Hub, Treorchy?

A Early support
B Carers
C Reduce isolation
D Practical advice
E Young people

Reply with your letter 👇
Results Next Saturday
#FeedbackFriday #RCT #Treorchy

MHM Wales

@mhmwales.bsky.social

1 week ago

Our friends at New Horizons Mental Health are running a free VR Mindfulness study.
Curious?

Come try the VR first at the Calfaria Wellbeing & Wellness Hub, Treorchy every Wednesday 10am–12pm before signing up.
Free to take part.

📋 form.jotform.com/251594113118...
#MentalHealth #Treorchy #RCT

JMIR Publications

@jmirpub.bsky.social

1 week ago

Effects of breathing exercises on #Pain, disability, range of motion and muscle endurance in #Patients with chronic low back #Pain, a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

MHM Wales

@mhmwales.bsky.social

1 week ago

Thank you Interlink RCT for the opportunity to speak at the Connecting Rhondda Communities event and share the work happening at the Calfaria Wellbeing & Wellness Hub, Treorchy.
Great to connect with partners working together to support wellbeing across the Rhondda.
#ConnectingRhondda #Treorchy #RCT

JMIR Publications

@jmirpub.bsky.social

1 week ago

Kidney-Tonifying, Phlegm-Resolving, and Blood Stasis–Removing Therapy for Multiple Myeloma: #Protocol for a #RCT #ClinicalTrial on Epigenetic and Immune Modulation Background: Multiple myeloma (MM) is characterized by kidney deficiency, phlegm, and blood stasis as core findings, specifically in Traditional Chinese Medicine (TCM), and the kidney-tonifying, phlegm-resolving, and blood stasis–removing (KPR) method is a fundamental therapeutic approach for MM in TCM. Western medicine primarily focuses on targeted immunotherapy or chemotherapy for MM treatment, whereas TCM characterizes MM through distinct pathological patterns that directly correspond to immune microenvironment dysregulation. Emerging evidence implicates the PHD finger protein 19 (PHF19)/enhancer of zeste homolog 2 (EZH2)/trimethylated histone H3 at lysine 27 (H3K27me3) epigenetic axis in immune microenvironment dysregulation and MM progression. Notably, TCM “blood stasis” correlates with hypoxia-induced immune gene silencing in MM bone marrow, and KPR (a clinically validated TCM decoction with 16 herbs) acts on this axis via its active components that regulate EZH2 and epigenetic function, merging TCM syndrome differentiation with modern epigenetics. We have designed a #RCT #ClinicalTrial (RCT) to investigate the mechanism of action and safety of the KPR method in MM. Objective: This RCT aims to assess whether a KPR herbal formula combined with standard bortezomib-based therapy improves the immune microenvironment via the PHF19-EZH2-H3K27me3 epigenetic axis to restore immune function in MM, providing a mechanistic basis for integrating TCM into evidence-based oncology care in relapsed or refractory patients. Methods: This is a single-center, prospective RCT involving patients with MM. It has been designed to test the hypothesis that the KPR formula epigenetically regulates the PHF19-EZH2-H3K27me3 axis to improve the immune microenvironment. Patients are randomly assigned in a 1:1:1 ratio to 3 groups (blank control group, Western medicine control group, and integrated TCM and Western medicine treatment group). All patients undergo 12 weeks of treatment and a 6-month follow-up. The primary outcome is the CD3 T-cell ratio in bone marrow/peripheral blood, which is detected by flow cytometry. The secondary outcomes include quantified TCM syndrome scores, Western medicine efficacy evaluation criteria, complete blood count, bone marrow morphology, blood and urine immunoglobulin levels, quantitative M protein levels, free light chain levels, β2-microglobulin levels, and whole-body imaging findings. Statistical analysis involves linear mixed models for longitudinal data and Bonferroni correction to verify KPR’s immunomodulatory effects via the targeted epigenetic axis. Results: This #Study was funded in November 2023. Recruitment was initiated in March 2025 and is expected to be completed in February 2026. As of October 2025, 41 patients have been enrolled. Data collection is projected to end in October 2026. Data analysis has not yet been initiated, and the results are expected to be published in 2027. Conclusions: This unique mechanistic RCT evaluating a TCM formula targeting the PHF19-EZH2-H3K27me3 axis in patients with MM will establish a biomarker-driven framework for integrating TCM with immunotherapy, offering novel strategies for treatment-refractory patients. Trial Registration: International Traditional Medicine Clinical Trial Registry ITMCTR2025000671; https://itmctr.ccebtcm.org.cn/mgt/project/view/4375050683463103813 and ITMCTR2025000449; https://itmctr.ccebtcm.org.cn/mgt/project/view/4779140633660123982 International Registered Report Identifier (IRRID): DERR1-10.2196/86322

JMIR Res Protocols: Kidney-Tonifying, Phlegm-Resolving, and Blood Stasis–Removing Therapy for Multiple Myeloma: #Protocol for a #RCT #ClinicalTrial on Epigenetic and Immune Modulation

Trials Change Lives

@trialschangelives.bsky.social

1 week ago

Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population - Cai, Z - 2026 | Cochrane Library Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

#CochraneDaily Around your health in 100 Cochrane Reviews #18 ASPIRIN FOR PREVENTING #ColorectalCancer Despite 10 #RCT with ~125,000 participants, this Feb 2026 review concludes that it was not possible to draw definitive conclusions about this use of #aspirin
www.cochranelibrary.com/cdsr/doi/10....

Vibrez Rugby 🇫🇷 🏉

@vibrezrugby.bsky.social

1 week ago

Rugby Club Toulonnais : Lemaître présente un projet de nouveau stade Le Rugby Club Toulonnais a dévoilé un projet de nouveau stade en bord de mer, présenté comme vital pour sa pérennité économique et sportive. Mayol, un stade historique mais en difficulté Les dirigeants du Rugby Club Toulonnais dressent un constat jugé implacable. Mayol, inauguré en 1920 et encastré en centre-ville, est décrit comme impossible à […] Cet article a été publié en premier sur Vibrez Rugby : Rugby Club Toulonnais : Lemaître présente un projet de nouveau stade

Rugby Club Toulonnais : Lemaître présente un projet de nouveau stade #RUGBY #TOP14 #TOULON #ParceQueToulon #RCT