Latest posts tagged with #RNAstructure on Bluesky
NCN @ncn.gov.pl project spotlight ๐ฌ
We investigate how mRNA folds in vivo, how its structure changes across the cell, and how RNA structure regulates gene expression in yeast. #RNA #mRNA #RNAstructure #GeneExpression #Yeast
Hi Bluesky โ welcome to KPW Lab!
We are interested in how #RNAstructure influences function, stability, and interactions in the cell.
Our work connects experimental #RNA structure probing with structural modeling and #bioinformatics. Weโre excited to share our science, publications, and tools here.
Top: A representative modeling example from Chimpanzee CPEB3 HDV-like ribozyme (PDB ID: 7QR3), with models predicted by four better-performing methods (blue cartoons) overlaid on experimental structure (gray cartoons). Left to right: DRFold2, DeepFoldRNA, AlphaFold3, RhoFold. Bottom: Structural visualization of the example from coxsackievirus B3 cloverleaf RNA (PDBID: 8DP3), showing experimental structure (left), AlphaFold3โs best prediction from 100 models (middle), and 5th model of DRfold2 (right), respectively. Structures are rainbow-colored from 5โฒ (blue) to 3โฒ (red) end.
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org ๐งช plos.io/4aoOQiX
Top: A representative modeling example from Chimpanzee CPEB3 HDV-like ribozyme (PDB ID: 7QR3), with models predicted by four better-performing methods (blue cartoons) overlaid on experimental structure (gray cartoons). Left to right: DRFold2, DeepFoldRNA, AlphaFold3, RhoFold. Bottom: Structural visualization of the example from coxsackievirus B3 cloverleaf RNA (PDBID: 8DP3), showing experimental structure (left), AlphaFold3โs best prediction from 100 models (middle), and 5th model of DRfold2 (right), respectively. Structures are rainbow-colored from 5โฒ (blue) to 3โฒ (red) end.
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org ๐งช plos.io/4aoOQiX
Top: A representative modeling example from Chimpanzee CPEB3 HDV-like ribozyme (PDB ID: 7QR3), with models predicted by four better-performing methods (blue cartoons) overlaid on experimental structure (gray cartoons). Left to right: DRFold2, DeepFoldRNA, AlphaFold3, RhoFold. Bottom: Structural visualization of the example from coxsackievirus B3 cloverleaf RNA (PDBID: 8DP3), showing experimental structure (left), AlphaFold3โs best prediction from 100 models (middle), and 5th model of DRfold2 (right), respectively. Structures are rainbow-colored from 5โฒ (blue) to 3โฒ (red) end.
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org ๐งช plos.io/4aoOQiX
A comprehensive survey of GNRA tetraloop-like motifs reveals 12 recurrent backbone topology variants, including pentaloop and multi-strand forms, revealing frequent protein interactions. #MotifDesign #RNAstructure #Bioinformatics ๐งฌ๐
๐ doi.org/10.1038/s415...
๐ค EVBC: Janusz Bujnicki
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
๐ฃ Don't miss this new Review!
Interplay between RNA-protein interactions and RNA structures in gene regulation
๐ buff.ly/pu6TpVa
๐๏ธ @rnaminni.bsky.social
#RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
Today I tested my own method for RNA analysis. This method can serve as an early indicator of RNA stability, even before detailed 3D modeling.
#Bioinformatics #ComputationalBiology #StructuralBiology #MolecularBiology #RNA #Biotechnology #LifeSciences #RNAresearch #RNAstructure #RNAfolding #LLM
(2/8) Predicting full 3D #RNAstructure remains extremely hard โ even with AI.
Recent benchmarks show deep-learning tools still struggle on novel RNAs (c.f. Bahai et al, 2024, PLoS Comp Bio)
And while AlphaFold 3 can model RNA, its accuracy lags far behind proteins: www.ebi.ac.uk/training/onl...
SEISMICgraph: a web-based tool for RNA structure data visualization. #RNAstructure #WebTool #DataVisualization #Bioinformatics @narjournal.bsky.social
academic.oup.com/nar/article/...
Calling #RNA & #Virology researchers! ๐งฌ๐ฆ
Submissions are open for the open-access Special Issue '๐๐๐ป๐ฐ๐๐ถ๐ผ๐ป๐ฎ๐น ๐ฅ๐ก๐๐ ๐ถ๐ป ๐ฉ๐ถ๐ฟ๐ผ๐น๐ผ๐ด๐' in MDPI Viruses, which I'm guest editing.
๐ Original research & reviews welcome!
๐๏ธ Deadline: Feb 28, 2026
michaelwolfinger.com/blog/2025/bl...
#FunctionalRNA #RNAstructure
Super new work from Chris and the team, including some cool #smFRET showing changes to n #RNAstructure- have a read!
I am in San Diego attending the #RNA25 annual meeting @rnasociety.bsky.social! Whether you work with #RNAstructure, are curious about ways to study it or have a favourite RNA that you would like to explore come to visit poster number 431 tonight! @miskalab.bsky.social
๐งฌ RNA is far more than just a blueprint for proteins! Its shape is crucial to its function. But how do we study RNA's complex structure?
๐ Find out at the 20th March RNA Club as we dive into groundbreaking techniques that are changing the game in RNA research!
#RNAstructure #RNA
๐ DesiRNA, our new RNA design tool, solved all 100 puzzles in the Eterna100 benchmark within 24 hours, outperforming all existing RNA design programs! ๐งฌ
๐ Read about it in Nucleic Acids Research: doi.org/10.1093/nar/...
#Science #Bioinformatics #ComputationalBiology #RNA #RNAstructure
Missed our recent webinar on New Methods for RNA Modification Detection and Structure Probing?
Explore innovative techniques that are transforming our understanding of #RNAmods and #RNAstructure.
Watch here: bit.ly/3TULhbr
#RNA #RNASky #structuralRNA
Did you know? The #ViennaRNA Package can handle a wide range of RNA modifications, including:
#Inosine (I)
#Pseudouridine (P)
#N6-methyladenosine (m6A)
#7-deaza-adenosine (7DA)
#Nebularine (purine)
#Dihydrouridine (D)
#Bioinformatics #ComputationalBiology #RNAStructure #SyntheticBiology
4/n
RNA-Puzzles Round V tackles RNA 3D structure prediction with 23 challenging targets from viral and non-viral origins, setting new benchmarks for RNA bioinformatics. ๐งฌ๐
#Bioinformatics #RNAstructure #ComputationalBiology
๐ doi.org/10.1038/s415...
EVBC๐ค: Tomasz K Wirecki
Super method linking GROseq/DMSMaPseq shedding light on co-transcriptional #RNA folding. Really enjoyed seeing this presented recently. #RNAStructure www.biorxiv.org/content/10.1...
This looks useful- will give it a go #RNAstructure
Could I be added to RNA Biology?
as #RNAstructure and #RNAfunction relationship fan ๐ซถ๐
Hi! ๐ I'm new here ๐
I recently defended my PhD and I'm loved in #RNA structures in vivo ๐ซถ Very excited to share my two articles at NAR (results of my PhD)!
1๐ academic.oup.com/nar/article/...
2๐ academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
.@AGbioDS from http://RNAfold.ai closing off this session of the @UNSWRNA annual symposium presenting his (and @oncogenie's) company, that leverages #AI to design new therapies targeting #RNAstructure and accessibility.
