It’s World AMR Awareness Week — themed Act Now: Protect Our Present, Secure Our Future. SCELSE is doing exactly that with this week’s sharing on exploiting cell wall-deficient Pseudomonas aeruginosa for new AMR solutions. Presented at the SCELSE Scientific Retreat, Alicia P. — a SCELSE PhD student under the supervision of Prof Cynthia Whitchurch FAA Whitchurch — highlighted a promising vulnerability in this highly drug-resistant pathogen. When exposed to very high beta-lactam levels, P. aeruginosa can enter a temporary cell wall-deficient state that increases drug influx and weakens efflux. In this window, the bacterium becomes far more sensitive to antibiotics and even FDA-approved non-antibiotic compounds. From a 1,443-compound screen, 81 showed potentiated activity, including 41 non-antibiotics that worked only in this weakened state. This opens new opportunities to repurpose existing drugs against Gram-negative infections. Next steps: To uncover mechanisms of action and explore how this vulnerability can be harnessed for therapeutic strategies.
World AMR Awareness Week calls us to act now. At the SCELSE retreat, PhD student Alicia Pek, supervised by Prof Cynthia Whitchurch, showed how cell wall-deficient P. aeruginosa reveals a vulnerability that boosts antibiotic & non-antibiotic activity.
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