(A) The canonical flow of information is outlined in gray, from the entorhinal cortex to DG granule cells (GCs), CA3, and then CA1 principal cells (PCs). PCs in noncanonical regions, which receive direct input from the hypothalamic supramammillary nucleus (SuM), are shown in green. (B) Large-amplitude events recorded from LFP in the DG hilus, known as dentate spikes, are associated with profound increases in brain-wide firing.
The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation.
In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. https://scim.ag/3VKRbMM